The epidemiology and clinical information about COVID-19

Huipeng Ge, Xiufen Wang, Xiangning Yuan, Gong Xiao, Chengzhi Wang, Tianci Deng, Qiongjing Yuan, Xiangcheng Xiao, Huipeng Ge, Xiufen Wang, Xiangning Yuan, Gong Xiao, Chengzhi Wang, Tianci Deng, Qiongjing Yuan, Xiangcheng Xiao

Abstract

In December 2019, pneumonia of unknown cause occurred in Wuhan, Hubei Province, China. On 7 January 2020, a novel coronavirus, named as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), was identified in the throat swab sample of one patient. The World Health Organization (WHO) announced the epidemic disease caused by SARS-CoV-2 as coronavirus disease 2019 (COVID-19). Currently, COVID-19 has spread widely around the world, affecting more than seventy countries. China, with a huge burden of this disease, has taken strong measures to control the spread and improve the curative rate of COVID-19. In this review, we summarized the epidemiological characteristics, clinical features, diagnosis, treatment, and prognosis of COVID-19. A comprehensive understanding will help to control the disease.

Keywords: Clinical; Coronavirus disease 2019; Epidemiology; Pathology; Severe acute respiratory syndrome coronavirus-2; Treatment.

Conflict of interest statement

All authors declared that they had no conflicts of interest.

Figures

Fig. 1
Fig. 1
Genome organization of SARS-CoV-2 in different studies [, , , –19]. ORF = open reading frame (orange). Structural proteins including S, E, M, N (blue) (S = spike, E = envelope, M = membrane, N = nucleocapsid). Accessory proteins including 3, 3a, 3b, 6, 7, 8, 9a, 9b, 10b, 13, 14 (purple). SP = signal peptide. S1 = subunit 1. S2 = subunit 2. NTD = N-terminal domain. RBD = receptor binding domain. ESD = external subdomain. FP = fusion peptide. HR1 = heptad repeat 1. HR2 = heptad repeat 2. TM = transmembrane domain. CP = cytoplasmic domain. The length of genes is not drawn in scale

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