Evidence for the involvement of interleukin 6 in experimental cancer cachexia
G Strassmann, M Fong, J S Kenney, C O Jacob, G Strassmann, M Fong, J S Kenney, C O Jacob
Abstract
In this report we describe an experimental model of cachexia that fulfills the criteria of an early effect with a small tumor mass not related to the growth rate of the tumor, and progressive wasting of muscle and fat without a detectable loss of appetite. C-26.IVX is a cell line derived from murine colon-26 adenocarcinoma which retains the transplantability of the original tumor and induces true cachexia in syngeneic hosts. Evidence is presented to support a role for interleukin (IL-6) as a cachectic factor in the development of cancer cachexia in this model system. Thus, increasing levels of IL-6 in C-26.IVX-bearing mice correlate with the development of cachexia. If the primary tumors were resected, mice gained weight and the levels of IL-6 in the serum were reduced significantly. Moreover, monoclonal antibody to murine IL-6 (but not anti-tumor necrosis factor antibody) was able to significantly suppress the development of key parameters of cachexia in tumor bearing mice.
References
- Cancer Res. 1975 Sep;35(9):2434-9
- Anal Biochem. 1966 Apr;15(1):45-52
- Hematol Oncol Clin North Am. 1991 Feb;5(1):103-23
- J Immunol. 1990 Dec 15;145(12):4185-91
- Cancer Res. 1990 Apr 15;50(8):2290-5
- J Immunol. 1989 Jul 1;143(1):162-7
- FASEB J. 1989 Jun;3(8):1956-62
- Crit Rev Oncol Hematol. 1987;7(4):289-327
- Clin Physiol. 1987 Aug;7(4):263-74
- Cell. 1987 Aug 14;50(4):555-63
- J Exp Med. 1985 May 1;161(5):984-95
- J Immunol. 1991 Aug 15;147(4):1279-85
- Br J Cancer. 1991 Mar;63(3):337-42
- Endocrinology. 1991 May;128(5):2657-9
- Cancer Res. 1991 Jun 1;51(11):2803-7
- Annu Rev Immunol. 1990;8:253-78
- J Exp Med. 1990 Oct 1;172(4):1193-200
- J Immunol. 1989 Jun 1;142(11):3884-93
- Ann N Y Acad Sci. 1989;557:130-41, discussion 141-3
- Lancet. 1987 Nov 28;2(8570):1229-32
- Ann Surg. 1989 Jan;209(1):19-24
- Cell. 1988 Jul 15;54(2):141-2
- J Exp Med. 1988 Mar 1;167(3):1211-27
- J Natl Cancer Inst. 1988 Jun 15;80(8):595-8
- Scand J Immunol. 1986 Dec;24(6):739-43
- Cancer Res. 1991 May 1;51(9):2302-6
Source: PubMed