Recombinant human gamma interferon inhibits simian malaria

R K Maheshwari, C W Czarniecki, G P Dutta, S K Puri, B N Dhawan, R M Friedman, R K Maheshwari, C W Czarniecki, G P Dutta, S K Puri, B N Dhawan, R M Friedman

Abstract

Prophylactic treatment with 0.1 mg of human gamma interferon per kg (body weight) per day completely suppressed experimental infection with Plasmodium cynomolgi B sporozoites in rhesus monkeys. Treatment with lower doses partially suppressed this infection. Prophylactic treatment with human gamma interferon, however, had no protective effect against trophozoite-induced infection, suggesting that the interferon effect was limited to the exoerythrocytic stage of parasitic development.

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