Hematopoietic Stem Cell Transplantation for Severe Combined Immunodeficiency
Justin T Wahlstrom, Christopher C Dvorak, Morton J Cowan, Justin T Wahlstrom, Christopher C Dvorak, Morton J Cowan
Abstract
Hematopoietic stem cell transplantation (HSCT) is an effective approach for the treatment of severe combined immunodeficiency (SCID). However, SCID is not a homogeneous disease, and the treatment required for successful transplantation varies significantly between SCID subtypes and the degree of HLA mismatch between the best available donor and the patient. Recent studies are beginning to more clearly define this heterogeneity and how outcomes may vary. With a more detailed understanding of SCID, new approaches can be developed to maximize immune reconstitution, while minimizing acute and long-term toxicities associated with chemotherapy conditioning.
Conflict of interest statement
Compliance with Ethics Guidelines: Conflicts of Interest: Justin T. Wahlstrom and Christopher C. Dvorak declare that they have no conflict of interest.
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Source: PubMed