Antistress, Adoptogenic Activity of Sida cordifolia Roots in Mice

Meera Sumanth, S S Mustafa, Meera Sumanth, S S Mustafa

Abstract

Ethanol extract of roots of Sida cordifolia was evaluated for antistress, adaptogenic activity using cold restraint stress and swim endurance in mice. Mice pretreated with extract of Sida cordifolia showed significant improvement in the swim duration and reduced the elevated WBC, blood glucose and plasma cortisone.

Keywords: Sida cordifolia; blood glucose and plasma cortisol; swim endurance test.

References

    1. Rice P. Restructuring and the production of occupational stressors in a corporatised ambulance service. Health Soc Rev. 1999;14:213–6.
    1. Available from: . [accessed on 2008 Jun 9]
    1. Kanth VR, Diwan PV. Analgesic, antiinflammatory and hypoglycaemic activities of Sida cordifolia. Phytother Res. 1999;13:75–7.
    1. Rao KS, Mishra SH. Antihepatotoxic activity of Sida cordifolia whole plant. Fitoterapia. 1998;LXIX:20–3.
    1. Sutradhar RK, Rahman MA, Ahmad MU, Datta BK, Bachar SC, Saha A. Analgesic and antiinflammatory activities of Sida cordifolia Linn. Indian J Pharmacol. 2006;38:207–8.
    1. Dhuley JN. Adaptogenic and cardioprotective action of Ashwagandha in rats and frogs. J Ethnopharmacol. 2000;70:57–63.
    1. Varley H, Gowenlock AH, Bell M. Practical biochemistry. 5th ed. London: William Heine Mann Medical Books Ltd; 1984. pp. 73–4.
    1. Thiebot MH, Martin P, Puech AJ. Animal behavioural studies in the evaluation of antidepressant drugs. Br J Psychiatry Suppl. 1992;15:44–50.
    1. Singh N, Verma P, Mishra N, Nath R. A comparative evaluation of some antistress agents of plant origin. Indian J Pharmacol. 1991;23:99–103.
    1. Negrao AB, Deuster PA, Gold PW, Singher A, Chrousos GP. Individual reactivity and physiology of the stress response. Neurology. 2000;54:122–8.
    1. Kiran Babu S, Gupta P, Bhatia G, Maurya R, Nath C, Palit G. Adaptogenic and anti-amnesic properties of Evolvulus alsinoides in rodents. Pharmacol Biochem Behavior. 2005;81:424–32.
    1. Tache Y, Selye H. Shift in adenohypophyseal activity during chronic intermittent immobilization of rats. Neuroendocrinol. 1976;22:325–36.
    1. Meera S, Mustafa SS. Antistress, adoptogenic and immunopotentiating activity of roots of Boerhaavia diffusa in mice. Int J Pharmacol. 2007;3:416–20.
    1. Dominiczak B. Medical Biochemistry. Mosby, London: 1999. Glucose homeostasis and fuel metabolism; pp. 257–58.

Source: PubMed

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