An Exercise and Educational and Self-management Program Delivered With a Smartphone App (CareHand) in Adults With Rheumatoid Arthritis of the Hands: Randomized Controlled Trial

Pablo Rodríguez Sánchez-Laulhé, Luis Gabriel Luque-Romero, Francisco José Barrero-García, Ángela Biscarri-Carbonero, Jesús Blanquero, Alejandro Suero-Pineda, Alberto Marcos Heredia-Rizo, Pablo Rodríguez Sánchez-Laulhé, Luis Gabriel Luque-Romero, Francisco José Barrero-García, Ángela Biscarri-Carbonero, Jesús Blanquero, Alejandro Suero-Pineda, Alberto Marcos Heredia-Rizo

Abstract

Background: Rheumatoid arthritis (RA) is a prevalent autoimmune disease that usually involves problems of the hand or wrist. Current evidence recommends a multimodal therapy including exercise, self-management, and educational strategies. To date, the efficacy of this approach, as delivered using a smartphone app, has been scarcely investigated.

Objective: This study aims to assess the short- and medium-term efficacy of a digital app (CareHand) that includes a tailored home exercise program, together with educational and self-management recommendations, compared with usual care, for people with RA of the hands.

Methods: A single-blinded randomized controlled trial was conducted between March 2020 and February 2021, including 36 participants with RA of the hands (women: 22/36, 61%) from 2 community health care centers. Participants were allocated to use the CareHand app, consisting of tailored exercise programs, and self-management and monitoring tools or to a control group that received a written home exercise routine and recommendations, as per the usual protocol provided at primary care settings. Both interventions lasted for 3 months (4 times a week). The primary outcome was hand function, assessed using the Michigan Hand Outcome Questionnaire (MHQ). Secondary measures included pain and stiffness intensity (visual analog scale), grip strength (dynamometer), pinch strength (pinch gauge), and upper limb function (shortened version of the Disabilities of the Arm, Shoulder, and Hand questionnaire). All measures were collected at baseline and at a 3-month follow-up. Furthermore, the MHQ and self-reported stiffness were assessed 6 months after baseline, whereas pain intensity and scores on the shortened version of the Disabilities of the Arm, Shoulder, and Hand questionnaire were collected at the 1-, 3-, and 6-month follow-ups.

Results: In total, 30 individuals, corresponding to 58 hands (CareHand group: 26/58, 45%; control group: 32/58, 55%), were included in the analysis; 53% (19/36) of the participants received disease-modifying antirheumatic drug treatment. The ANOVA demonstrated a significant time×group effect for the total score of the MHQ (F1.62,85.67=9.163; P<.001; η2=0.15) and for several of its subscales: overall hand function, work performance, pain, and satisfaction (all P<.05), with mean differences between groups for the total score of 16.86 points (95% CI 8.70-25.03) at 3 months and 17.21 points (95% CI 4.78-29.63) at 6 months. No time×group interaction was observed for the secondary measures (all P>.05).

Conclusions: Adults with RA of the hands who used the CareHand app reported better results in the short and medium term for overall hand function, work performance, pain, and satisfaction, compared with usual care. The findings of this study suggest that the CareHand app is a promising tool for delivering exercise therapy and self-management recommendations to this population. Results must be interpreted with caution because of the lack of efficacy of the secondary outcomes.

Trial registration: ClinicalTrials.gov NCT04263974; https://ichgcp.net/clinical-trials-registry/NCT04263974.

International registered report identifier (irrid): RR2-10.1186/s13063-020-04713-4.

Keywords: exercise therapy; health education; mHealth; mobile applications; mobile phone; physical therapy; primary health care; rheumatoid arthritis; self-management; telehealth; telerehabilitation.

Conflict of interest statement

Conflicts of Interest: JB, ASP, and PRSL have been members of the ReHand project since 2016 and are part of the spin-off (Healthinn) that has designed and developed the CareHand app.

©Pablo Rodríguez Sánchez-Laulhé, Luis Gabriel Luque-Romero, Francisco José Barrero-García, Ángela Biscarri-Carbonero, Jesús Blanquero, Alejandro Suero-Pineda, Alberto Marcos Heredia-Rizo. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 07.04.2022.

Figures

Figure 1
Figure 1
Exercise program of the CareHand app, including explanatory videos of mobility, strengthening, and stretching exercises.
Figure 2
Figure 2
Features of the CareHand app. (A) Self-monitoring for pain intensity, (B) graphical representation of patient progress and adherence to exercises, and (C) educational advices section with information about joint protection and general recommendations.
Figure 3
Figure 3
CONSORT (Consolidated Standards of Reporting Trials) flowchart of participants. QuickDASH: shortened version of the Disabilities of the Arm, Shoulder, and Hand questionnaire; RA: rheumatoid arthritis.

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Source: PubMed

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