Viral Infection in Adults with Severe Acute Respiratory Infection in Colombia

Yuly Andrea Remolina, María Mercedes Ulloa, Hernán Vargas, Liliana Díaz, Sandra Liliana Gómez, Alfredo Saavedra, Edgar Sánchez, Jorge Alberto Cortés, Yuly Andrea Remolina, María Mercedes Ulloa, Hernán Vargas, Liliana Díaz, Sandra Liliana Gómez, Alfredo Saavedra, Edgar Sánchez, Jorge Alberto Cortés

Abstract

Objectives: To identify the viral aetiology in adult patients with severe acute respiratory infection (SARI) admitted to sentinel surveillance institutions in Bogotá in 2012.

Design: A cross-sectional study was conducted in which microarray molecular techniques for viral identification were used on nasopharyngeal samples of adult patients submitted to the surveillance system, and further descriptions of clinical features and relevant clinical outcomes, such as mortality, need for critical care, use of mechanical ventilation and hospital stay, were obtained.

Setting: Respiratory infections requiring hospital admission in surveillance centres in Bogotá, Colombia.

Participants: Ninety-one adult patients with acute respiratory infection (55% were female).

Measurements: Viral identification, intensive care unit admission, hospital stay, and mortality.

Results: Viral identification was achieved for 63 patients (69.2%). Comorbidity was frequently identified and mainly involved chronic pulmonary disease or pregnancy. Influenza, Bocavirus and Adenovirus were identified in 30.8%, 28.6% and 18.7% of the cases, respectively. Admission to the intensive care unit occurred in 42.9% of the cases, while mechanical ventilation was required for 36.3%. The average hospital stay was 9.9 days, and mortality was 15.4%. Antibiotics were empirically used in 90.1% of patients.

Conclusions: The prevalence of viral aetiology of SARI in this study was high, with adverse clinical outcomes, intensive care requirements and high mortality.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1. Flow diagram of subject identification,…
Fig 1. Flow diagram of subject identification, sample processing and categorisation.
Four patients did not have molecular results (right arm).
Fig 2. Monthly frequency of patients with…
Fig 2. Monthly frequency of patients with viral Identification through 2012.

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