International retrospective study of the pipeline embolization device: a multicenter aneurysm treatment study
D F Kallmes, R Hanel, D Lopes, E Boccardi, A Bonafé, S Cekirge, D Fiorella, P Jabbour, E Levy, C McDougall, A Siddiqui, I Szikora, H Woo, F Albuquerque, H Bozorgchami, S R Dashti, J E Delgado Almandoz, M E Kelly, R Turner 4th, B K Woodward, W Brinjikji, G Lanzino, P Lylyk, D F Kallmes, R Hanel, D Lopes, E Boccardi, A Bonafé, S Cekirge, D Fiorella, P Jabbour, E Levy, C McDougall, A Siddiqui, I Szikora, H Woo, F Albuquerque, H Bozorgchami, S R Dashti, J E Delgado Almandoz, M E Kelly, R Turner 4th, B K Woodward, W Brinjikji, G Lanzino, P Lylyk
Abstract
Background and purpose: Flow diverters are increasingly used in the endovascular treatment of intracranial aneurysms. Our aim was to determine neurologic complication rates following Pipeline Embolization Device placement for intracranial aneurysm treatment in a real-world setting.
Materials and methods: We retrospectively evaluated all patients with intracranial aneurysms treated with the Pipeline Embolization Device between July 2008 and February 2013 in 17 centers worldwide. We defined 4 subgroups: internal carotid artery aneurysms of ≥10 mm, ICA aneurysms of <10 mm, other anterior circulation aneurysms, and posterior circulation aneurysms. Neurologic complications included spontaneous rupture, intracranial hemorrhage, ischemic stroke, permanent cranial neuropathy, and mortality. Comparisons were made with t tests or ANOVAs for continuous variables and the Pearson χ(2) or Fisher exact test for categoric variables.
Results: In total, 793 patients with 906 aneurysms were included. The neurologic morbidity and mortality rate was 8.4% (67/793), highest in the posterior circulation group (16.4%, 9/55) and lowest in the ICA <10-mm group (4.8%, 14/294) (P = .01). The spontaneous rupture rate was 0.6% (5/793). The intracranial hemorrhage rate was 2.4% (19/793). Ischemic stroke rates were 4.7% (37/793), highest in patients with posterior circulation aneurysms (7.3%, 4/55) and lowest in the ICA <10-mm group (2.7%, 8/294) (P = .16). Neurologic mortality was 3.8% (30/793), highest in the posterior circulation group (10.9%, 6/55) and lowest in the anterior circulation ICA <10-mm group (1.4%, 4/294) (P < .01).
Conclusions: Aneurysm treatment with the Pipeline Embolization Device is associated with the lowest complication rates when used to treat small ICA aneurysms. Procedure-related morbidity and mortality are higher in the treatment of posterior circulation and giant aneurysms.
© 2015 by American Journal of Neuroradiology.
Source: PubMed