Response to steroids predicts response to rituximab in pediatric chronic immune thrombocytopenia
Rachael F Grace, Carolyn M Bennett, A Kim Ritchey, Michael Jeng, Courtney D Thornburg, Michele P Lambert, Michelle Neier, Michael Recht, Manjusha Kumar, Victor Blanchette, Robert J Klaassen, George R Buchanan, Margaret Heisel Kurth, Diane J Nugent, Alexis A Thompson, Kimo Stine, Leslie A Kalish, Ellis J Neufeld, Rachael F Grace, Carolyn M Bennett, A Kim Ritchey, Michael Jeng, Courtney D Thornburg, Michele P Lambert, Michelle Neier, Michael Recht, Manjusha Kumar, Victor Blanchette, Robert J Klaassen, George R Buchanan, Margaret Heisel Kurth, Diane J Nugent, Alexis A Thompson, Kimo Stine, Leslie A Kalish, Ellis J Neufeld
Abstract
Background: Treatment choice in pediatric immune thrombocytopenia (ITP) is arbitrary, because few studies are powered to identify predictors of therapy response. Increasingly, rituximab is becoming a treatment of choice in those refractory to other therapies.
Methods: The objective of this study was to evaluate univariate and multivariable predictors of platelet count response to rituximab. After local IRB approval, 565 patients with chronic ITP enrolled and met criteria for this study in the longitudinal, North American Chronic ITP Registry (NACIR) between January 2004 and October 2010. Treatment response was defined as a post-treatment platelet count ≥ 50,000/µl within 16 weeks of rituximab and 14 days of steroids. Treatment response data were captured both retrospectively at enrollment and then prospectively.
Results: Eighty (14.2%) patients were treated with rituximab with an overall response rate of 63.8% (51/80). Univariate correlates of response to rituximab included the presence of secondary ITP and a positive response to steroids. In multivariable analysis, response to steroids remained a strong correlate of response to rituximab, OR 6.8 (95% CI 2.0-23.0, P = 0.002). Secondary ITP also remained a strong predictor of response to rituximab, OR 5.6 (95% CI 1.1-28.6, P = 0.04). Although 87.5% of patients who responded to steroids responded to rituximab, 48% with a negative response to steroids did respond to rituximab.
Conclusion: In the NACIR, response to steroids and presence of secondary ITP were strong correlates of response to rituximab, a finding not previously reported in children or adults.
Conflict of interest statement
Conflict of interest: Michele P. Lambert: advisory committee for Cangene; Robert J. Klaassen: grant funding from Cangene. The other authors have no relevant conflicts of interest.
Copyright © 2011 Wiley Periodicals, Inc.
Source: PubMed