联合疗法治疗高危 II-IIIB 期肛门癌患者后的纳武利尤单抗
2026年10月30日 更新者：National Cancer Institute (NCI)
Nivolumab 在高危肛门癌联合治疗 (CMT) 后的随机 III 期研究
This phase III trial investigates how well nivolumab after combined modality therapy works in treating patients with high risk stage II-IIIB anal cancer. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
研究概览
地位
地位
主动，不招人
条件
条件
干预/治疗
干预/治疗
详细说明
PRIMARY OBJECTIVE:
I. To evaluate whether therapy with nivolumab following combined modality therapy (CMT) improves disease-free survival (DFS) compared with observation in patients with high risk anal carcinoma.
SECONDARY OBJECTIVES:
I. To compare nivolumab following combined modality therapy (CMT) with observation in patients with high risk anal carcinoma with regard to:
Ia. Objective response rate (complete [CR] and partial [PR]), stable disease and progression.
Ib. Severe toxicity interval. Ic. Colostomy-free survival. Id. Overall survival. Ie. Toxicity.
OUTLINE: Patients who received standard CMT are randomized to 1 of 2 arms.
ARM A: Patients receive nivolumab intravenously (IV) while on study.
ARM B: Patients undergo observation while on study
Patients undergo sigmoidoscopy, colonoscopy or anoscopy, proctoscopy or digital rectal exam, x-ray, computed tomography (CT) scan, magnetic resonance imaging (MRI), biopsy and blood sample collection throughout the study.
研究类型
研究类型
介入性
注册 (估计的)
注册
344
阶段
阶段
- 第三阶段
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
-
-
Alberta
-
Calgary、Alberta、加拿大、T2N 5G2
- Arthur J E Child Comprehensive Cancer Centre
-
-
British Columbia
-
Vancouver、British Columbia、加拿大、V5Z 4E6
- BCCA-Vancouver Cancer Centre
-
-
Newfoundland and Labrador
-
St. John's、Newfoundland and Labrador、加拿大、A1B 3V6
- Doctor H. Bliss Murphy Cancer Centre
-
-
Ontario
-
London、Ontario、加拿大、N6A 4L6
- London Regional Cancer Program
-
Ottawa、Ontario、加拿大、K1H 8L6
- Ottawa Hospital and Cancer Center-General Campus
-
Sault Ste. Marie、Ontario、加拿大、P6B 0A8
- Algoma District Cancer Program Sault Area Hospital
-
Toronto、Ontario、加拿大、M5G 2M9
- University Health Network-Princess Margaret Hospital
-
-
Saskatchewan
-
Regina、Saskatchewan、加拿大、S4T 7T1
- Allan Blair Cancer Centre
-
Saskatoon、Saskatchewan、加拿大、S7N 4H4
- Saskatoon Cancer Centre
-
-
-
-
Alabama
-
Birmingham、Alabama、美国、35233
- University of Alabama at Birmingham Cancer Center
-
-
Alaska
-
Anchorage、Alaska、美国、98508
- Anchorage Associates in Radiation Medicine
-
Anchorage、Alaska、美国、99508
- Alaska Breast Care and Surgery LLC
-
Anchorage、Alaska、美国、99508
- Alaska Oncology and Hematology LLC
-
Anchorage、Alaska、美国、99508
- Alaska Women's Cancer Care
-
Anchorage、Alaska、美国、99508
- Anchorage Oncology Centre
-
Anchorage、Alaska、美国、99508
- Katmai Oncology Group
-
Anchorage、Alaska、美国、99508
- Providence Alaska Medical Center
-
Anchorage、Alaska、美国、99504
- Anchorage Radiation Therapy Center
-
Fairbanks、Alaska、美国、99701
- Fairbanks Memorial Hospital
-
-
Arizona
-
Goodyear、Arizona、美国、85338
- CTCA at Western Regional Medical Center
-
Kingman、Arizona、美国、86401
- Kingman Regional Medical Center
-
Phoenix、Arizona、美国、85054
- Mayo Clinic Hospital in Arizona
-
Scottsdale、Arizona、美国、85259
- Mayo Clinic in Arizona
-
-
Arkansas
-
Fort Smith、Arkansas、美国、72903
- Mercy Hospital Fort Smith
-
Hot Springs、Arkansas、美国、71913
- CHI Saint Vincent Cancer Center Hot Springs
-
Jonesboro、Arkansas、美国、72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
-
Little Rock、Arkansas、美国、72205
- University of Arkansas for Medical Sciences
-
-
California
-
Anaheim、California、美国、92806
- Kaiser Permanente-Anaheim
-
Antioch、California、美国、94531
- Kaiser Permanente-Deer Valley Medical Center
-
Arroyo Grande、California、美国、93420
- PCR Oncology
-
Arroyo Grande、California、美国、93420
- Mission Hope Medical Oncology - Arroyo Grande
-
Auburn、California、美国、95602
- Sutter Auburn Faith Hospital
-
Auburn、California、美国、95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
-
Baldwin Park、California、美国、91706
- Kaiser Permanente-Baldwin Park
-
Bellflower、California、美国、90706
- Kaiser Permanente-Bellflower
-
Berkeley、California、美国、94704
- Alta Bates Summit Medical Center-Herrick Campus
-
Burbank、California、美国、91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
-
Burlingame、California、美国、94010
- Mills-Peninsula Medical Center
-
Cameron Park、California、美国、95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
-
Castro Valley、California、美国、94546
- Eden Hospital Medical Center
-
Chico、California、美国、95926
- Enloe Medical Center
-
Clovis、California、美国、93611
- Community Cancer Institute
-
Clovis、California、美国、93611
- University Oncology Associates
-
Davis、California、美国、95616
- Sutter Davis Hospital
-
Dublin、California、美国、94568
- Kaiser Permanente Dublin
-
Fontana、California、美国、92335
- Kaiser Permanente-Fontana
-
Fremont、California、美国、94538
- Kaiser Permanente-Fremont
-
Fremont、California、美国、94538
- Palo Alto Medical Foundation-Fremont
-
Fresno、California、美国、93720
- Kaiser Permanente-Fresno
-
Fresno、California、美国、93720
- Fresno Cancer Center
-
Harbor City、California、美国、90710
- Kaiser Permanente South Bay
-
Irvine、California、美国、92618
- Kaiser Permanente-Irvine
-
La Jolla、California、美国、92093
- UC San Diego Moores Cancer Center
-
Los Angeles、California、美国、90033
- USC / Norris Comprehensive Cancer Center
-
Los Angeles、California、美国、90027
- Kaiser Permanente Los Angeles Medical Center
-
Los Angeles、California、美国、90034
- Kaiser Permanente West Los Angeles
-
Los Angeles、California、美国、90033
- Los Angeles General Medical Center
-
Marysville、California、美国、95901
- Fremont - Rideout Cancer Center
-
Modesto、California、美国、95355
- Memorial Medical Center
-
Modesto、California、美国、95356
- Kaiser Permanente-Modesto
-
Mountain View、California、美国、94040
- Palo Alto Medical Foundation-Camino Division
-
Mountain View、California、美国、94040
- Palo Alto Medical Foundation-Gynecologic Oncology
-
Newport Beach、California、美国、92663
- USC Norris Oncology/Hematology-Newport Beach
-
Novato、California、美国、94945
- Sutter Cancer Research Consortium
-
Oakland、California、美国、94611
- Kaiser Permanente-Oakland
-
Oakland、California、美国、94611
- Kaiser Permanente Oakland-Broadway
-
Ontario、California、美国、91761
- Kaiser Permanente-Ontario
-
Orange、California、美国、92868
- Saint Joseph Hospital - Orange
-
Palo Alto、California、美国、94304
- Stanford Cancer Institute Palo Alto
-
Palo Alto、California、美国、94301
- Palo Alto Medical Foundation Health Care
-
Panorama City、California、美国、91402
- Kaiser Permanente - Panorama City
-
Pasadena、California、美国、91105
- Keck Medical Center of USC Pasadena
-
Rancho Cordova、California、美国、95670
- Kaiser Permanente-Rancho Cordova Cancer Center
-
Rancho Mirage、California、美国、92270
- Eisenhower Medical Center
-
Redwood City、California、美国、94063
- Kaiser Permanente-Redwood City
-
Richmond、California、美国、94801
- Kaiser Permanente-Richmond
-
Riverside、California、美国、92505
- Kaiser Permanente-Riverside
-
Rohnert Park、California、美国、94928
- Rohnert Park Cancer Center
-
Roseville、California、美国、95678
- The Permanente Medical Group-Roseville Radiation Oncology
-
Roseville、California、美国、95661
- Kaiser Permanente-Roseville
-
Roseville、California、美国、95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
-
Roseville、California、美国、95661
- Sutter Roseville Medical Center
-
Sacramento、California、美国、95816
- Sutter Medical Center Sacramento
-
Sacramento、California、美国、95817
- University of California Davis Comprehensive Cancer Center
-
Sacramento、California、美国、95814
- Kaiser Permanente Downtown Commons
-
Sacramento、California、美国、95823
- Kaiser Permanente-South Sacramento
-
Sacramento、California、美国、95823
- South Sacramento Cancer Center
-
Sacramento、California、美国、95825
- Kaiser Permanente Sacramento Medical Center
-
San Diego、California、美国、92120
- Kaiser Permanente-San Diego Zion
-
San Diego、California、美国、92108
- Kaiser Permanente-Rio San Diego
-
San Francisco、California、美国、94115
- Kaiser Permanente-San Francisco
-
San Francisco、California、美国、94115
- California Pacific Medical Center-Pacific Campus
-
San Francisco、California、美国、94110
- Zuckerberg San Francisco General Hospital
-
San Jose、California、美国、95119
- Kaiser Permanente-Santa Teresa-San Jose
-
San Leandro、California、美国、94577
- Kaiser Permanente San Leandro
-
San Marcos、California、美国、92078
- Kaiser Permanente-San Marcos
-
San Mateo、California、美国、94401
- Mills Health Center
-
San Rafael、California、美国、94903
- Kaiser San Rafael-Gallinas
-
San Rafael、California、美国、94903
- Kaiser Permanente-San Rafael
-
Santa Clara、California、美国、95051
- Kaiser Permanente Medical Center - Santa Clara
-
Santa Cruz、California、美国、95065
- Palo Alto Medical Foundation-Santa Cruz
-
Santa Maria、California、美国、93444
- Mission Hope Medical Oncology - Santa Maria
-
Santa Rosa、California、美国、95403
- Kaiser Permanente-Santa Rosa
-
Santa Rosa、California、美国、95403
- Sutter Pacific Medical Foundation
-
South San Francisco、California、美国、94080
- Kaiser Permanente Cancer Treatment Center
-
South San Francisco、California、美国、94080
- Kaiser Permanente-South San Francisco
-
Stockton、California、美国、95210
- Kaiser Permanente-Stockton
-
Sunnyvale、California、美国、94086
- Palo Alto Medical Foundation-Sunnyvale
-
Vacaville、California、美国、95688
- Kaiser Permanente Medical Center-Vacaville
-
Vallejo、California、美国、94589
- Kaiser Permanente-Vallejo
-
Vallejo、California、美国、94589
- Sutter Solano Medical Center/Cancer Center
-
Walnut Creek、California、美国、94596
- Kaiser Permanente-Walnut Creek
-
Woodland Hills、California、美国、91367
- Kaiser Permanente-Woodland Hills
-
-
Colorado
-
Aurora、Colorado、美国、80012
- Rocky Mountain Cancer Centers-Aurora
-
Aurora、Colorado、美国、80012
- The Medical Center of Aurora
-
Aurora、Colorado、美国、80045
- UCHealth University of Colorado Hospital
-
Boulder、Colorado、美国、80304
- Rocky Mountain Cancer Centers-Boulder
-
Colorado Springs、Colorado、美国、80907
- Penrose-Saint Francis Healthcare
-
Colorado Springs、Colorado、美国、80909
- UCHealth Memorial Hospital Central
-
Colorado Springs、Colorado、美国、80907
- Rocky Mountain Cancer Centers-Penrose
-
Colorado Springs、Colorado、美国、80920
- Memorial Hospital North
-
Denver、Colorado、美国、80205
- Kaiser Permanente-Franklin
-
Denver、Colorado、美国、80218
- Presbyterian - Saint Lukes Medical Center - Health One
-
Denver、Colorado、美国、80220
- Rose Medical Center
-
Denver、Colorado、美国、80218
- Rocky Mountain Cancer Centers-Midtown
-
Denver、Colorado、美国、80220
- Rocky Mountain Cancer Centers-Rose
-
Denver、Colorado、美国、80204
- Denver Health Medical Center
-
Denver、Colorado、美国、80218
- Colorado Blood Cancer Institute
-
Denver、Colorado、美国、80204
- Cancer Center of Colorado at Sloan's Lake
-
Denver、Colorado、美国、80209
- The Women's Imaging Center
-
Denver、Colorado、美国、80206
- National Jewish Health-Main Campus
-
Denver、Colorado、美国、80220
- Western Surgical Care
-
Denver、Colorado、美国、80218
- Saint Joseph Hospital - Cancer Centers of Colorado
-
Denver、Colorado、美国、80210
- AdventHealth Porter
-
Durango、Colorado、美国、81301
- Mercy Medical Center
-
Durango、Colorado、美国、81301
- CommonSpirit Cancer Center Mercy
-
Englewood、Colorado、美国、80113
- Mountain Blue Cancer Care Center - Swedish
-
Englewood、Colorado、美国、80113
- Swedish Medical Center
-
Fort Collins、Colorado、美国、80524
- Poudre Valley Hospital
-
Golden、Colorado、美国、80401
- Mountain Blue Cancer Care Center
-
Golden、Colorado、美国、80401
- National Jewish Health-Western Hematology Oncology
-
Grand Junction、Colorado、美国、81501
- Saint Mary's Hospital and Regional Medical Center
-
Greeley、Colorado、美国、80631
- Banner North Colorado Medical Center
-
Lafayette、Colorado、美国、80026
- Kaiser Permanente-Rock Creek
-
Lafayette、Colorado、美国、80026
- Good Samaritan Hospital - Cancer Centers of Colorado
-
Lakewood、Colorado、美国、80228
- Rocky Mountain Cancer Centers-Lakewood
-
Lakewood、Colorado、美国、80228
- CommonSpirit Saint Anthony Hospital Cancer Center
-
Littleton、Colorado、美国、80120
- Rocky Mountain Cancer Centers-Littleton
-
Littleton、Colorado、美国、80122
- AdventHealth Littleton
-
Lone Tree、Colorado、美国、80124
- Kaiser Permanente-Lone Tree
-
Lone Tree、Colorado、美国、80124
- Sky Ridge Medical Center
-
Lone Tree、Colorado、美国、80124
- Rocky Mountain Cancer Centers-Sky Ridge
-
Longmont、Colorado、美国、80501
- Longmont United Hospital
-
Longmont、Colorado、美国、80501
- Rocky Mountain Cancer Centers-Longmont
-
Loveland、Colorado、美国、80539
- Banner North Colorado Medical Center - Loveland Campus
-
Parker、Colorado、美国、80138
- Rocky Mountain Cancer Centers-Parker
-
Parker、Colorado、美国、80138
- AdventHealth Parker
-
Pueblo、Colorado、美国、81004
- Saint Mary Corwin Medical Center
-
Pueblo、Colorado、美国、81008
- Rocky Mountain Cancer Centers - Pueblo
-
Thornton、Colorado、美国、80260
- Rocky Mountain Cancer Centers-Thornton
-
Thornton、Colorado、美国、80260
- National Jewish Health-Northern Hematology Oncology
-
Wheat Ridge、Colorado、美国、80401
- Intermountain Health Lutheran Hospital
-
-
Delaware
-
Lewes、Delaware、美国、19958
- Beebe Medical Center
-
Millville、Delaware、美国、19967
- Beebe South Coastal Health Campus
-
Newark、Delaware、美国、19713
- Helen F Graham Cancer Center
-
Newark、Delaware、美国、19713
- Delaware Clinical and Laboratory Physicians PA
-
Newark、Delaware、美国、19713
- Medical Oncology Hematology Consultants PA
-
Newark、Delaware、美国、19718
- Christiana Care Health System-Christiana Hospital
-
Rehoboth Beach、Delaware、美国、19971
- Beebe Health Campus
-
Seaford、Delaware、美国、19973
- TidalHealth Nanticoke / Allen Cancer Center
-
Wilmington、Delaware、美国、19801
- Christiana Care Health System-Wilmington Hospital
-
-
District of Columbia
-
Washington D.C.、District of Columbia、美国、20037
- George Washington University Medical Center
-
-
Florida
-
Altamonte Springs、Florida、美国、32701
- AdventHealth Altamonte
-
Aventura、Florida、美国、33180
- Mount Sinai Comprehensive Cancer Center at Aventura
-
Celebration、Florida、美国、34747
- AdventHealth Celebration
-
Coral Gables、Florida、美国、33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
-
Deerfield Beach、Florida、美国、33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
-
Fort Lauderdale、Florida、美国、33316
- Broward Health Medical Center
-
Fort Lauderdale、Florida、美国、33308
- Holy Cross Hospital
-
Gainesville、Florida、美国、32610
- UF Health Cancer Institute - Gainesville
-
Hollywood、Florida、美国、33021
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
-
Jacksonville、Florida、美国、32224-9980
- Mayo Clinic in Florida
-
Kissimmee、Florida、美国、34744
- AdventHealth Kissimmee
-
Miami、Florida、美国、33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
-
Miami、Florida、美国、33176
- UM Sylvester Comprehensive Cancer Center at Kendall
-
Miami Beach、Florida、美国、33140
- Mount Sinai Medical Center
-
Orlando、Florida、美国、32803
- AdventHealth Orlando
-
Orlando、Florida、美国、32803
- AdventHealth Medical Group Urology at Orlando
-
Orlando、Florida、美国、32822
- AdventHealth East Orlando
-
Pembroke Pines、Florida、美国、33028
- Memorial Hospital West
-
Pensacola、Florida、美国、32504
- Sacred Heart Hospital
-
Weston、Florida、美国、33331
- Cleveland Clinic-Weston
-
Winter Park、Florida、美国、32792
- AdventHealth Winter Park
-
-
Georgia
-
Atlanta、Georgia、美国、30308
- Emory University Hospital Midtown
-
Atlanta、Georgia、美国、30322
- Emory University Hospital/Winship Cancer Institute
-
Atlanta、Georgia、美国、30342
- Emory Saint Joseph's Hospital
-
Atlanta、Georgia、美国、30303
- Grady Health System
-
Atlanta、Georgia、美国、30309
- Piedmont Hospital
-
Decatur、Georgia、美国、30033
- Atlanta VA Medical Center
-
Fayetteville、Georgia、美国、30214
- Piedmont Fayette Hospital
-
Johns Creek、Georgia、美国、30097
- Emory Johns Creek Hospital
-
Savannah、Georgia、美国、31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
-
Savannah、Georgia、美国、31405
- Summit Cancer Care-Candler
-
-
Hawaii
-
Honolulu、Hawaii、美国、96819
- Kaiser Permanente Moanalua Medical Center
-
-
Idaho
-
Boise、Idaho、美国、83706
- Saint Alphonsus Cancer Care Center-Boise
-
Boise、Idaho、美国、83712
- Saint Luke's Cancer Institute - Boise
-
Caldwell、Idaho、美国、83605
- Saint Alphonsus Cancer Care Center-Caldwell
-
Coeur d'Alene、Idaho、美国、83814
- Kootenai Health - Coeur d'Alene
-
Emmett、Idaho、美国、83617
- Walter Knox Memorial Hospital
-
Fruitland、Idaho、美国、83619
- Saint Luke's Cancer Institute - Fruitland
-
Meridian、Idaho、美国、83642
- Idaho Urologic Institute-Meridian
-
Meridian、Idaho、美国、83642
- Saint Luke's Cancer Institute - Meridian
-
Nampa、Idaho、美国、83687
- Saint Alphonsus Cancer Care Center-Nampa
-
Nampa、Idaho、美国、83687
- Saint Luke's Cancer Institute - Nampa
-
Post Falls、Idaho、美国、83854
- Kootenai Clinic Cancer Services - Post Falls
-
Sandpoint、Idaho、美国、83864
- Kootenai Clinic Cancer Services - Sandpoint
-
Twin Falls、Idaho、美国、83301
- Saint Luke's Cancer Institute - Twin Falls
-
-
Illinois
-
Aurora、Illinois、美国、60504
- Rush-Copley Medical Center
-
Bloomington、Illinois、美国、61704
- Illinois CancerCare-Bloomington
-
Burr Ridge、Illinois、美国、60527
- Loyola Center for Health at Burr Ridge
-
Canton、Illinois、美国、61520
- Illinois CancerCare-Canton
-
Carbondale、Illinois、美国、62902
- Memorial Hospital of Carbondale
-
Carterville、Illinois、美国、62918
- SIH Cancer Institute
-
Carthage、Illinois、美国、62321
- Illinois CancerCare-Carthage
-
Centralia、Illinois、美国、62801
- Centralia Oncology Clinic
-
Chicago、Illinois、美国、60611
- Northwestern University
-
Chicago、Illinois、美国、60612
- University of Illinois
-
Chicago、Illinois、美国、60612
- Rush MD Anderson Cancer Center
-
Danville、Illinois、美国、61832
- Carle at The Riverfront
-
Decatur、Illinois、美国、62526
- Decatur Memorial Hospital
-
Decatur、Illinois、美国、62526
- Cancer Care Specialists of Illinois - Decatur
-
Dixon、Illinois、美国、61021
- Illinois CancerCare-Dixon
-
Effingham、Illinois、美国、62401
- Crossroads Cancer Center
-
Effingham、Illinois、美国、62401
- Carle Physician Group-Effingham
-
Eureka、Illinois、美国、61530
- Illinois CancerCare-Eureka
-
Evanston、Illinois、美国、60201
- NorthShore University HealthSystem-Evanston Hospital
-
Galesburg、Illinois、美国、61401
- Western Illinois Cancer Treatment Center
-
Galesburg、Illinois、美国、61401
- Illinois CancerCare-Galesburg
-
Glenview、Illinois、美国、60026
- NorthShore University HealthSystem-Glenbrook Hospital
-
Highland Park、Illinois、美国、60035
- NorthShore University HealthSystem-Highland Park Hospital
-
Homer Glen、Illinois、美国、60491
- Loyola Medicine Homer Glen
-
Kewanee、Illinois、美国、61443
- Illinois CancerCare-Kewanee Clinic
-
Lake Forest、Illinois、美国、60045
- Northwestern Medicine Lake Forest Hospital
-
Macomb、Illinois、美国、61455
- Illinois CancerCare-Macomb
-
Mattoon、Illinois、美国、61938
- Carle Physician Group-Mattoon/Charleston
-
Maywood、Illinois、美国、60153
- Loyola University Medical Center
-
Melrose Park、Illinois、美国、60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
-
Mount Vernon、Illinois、美国、62864
- SSM Health Good Samaritan
-
O'Fallon、Illinois、美国、62269
- Cancer Care Center of O'Fallon
-
Ottawa、Illinois、美国、61350
- Illinois CancerCare-Ottawa Clinic
-
Pekin、Illinois、美国、61554
- Illinois CancerCare-Pekin
-
Pekin、Illinois、美国、61554
- OSF Saint Francis Radiation Oncology at Pekin
-
Peoria、Illinois、美国、61636
- Methodist Medical Center of Illinois
-
Peoria、Illinois、美国、61637
- OSF Saint Francis Medical Center
-
Peoria、Illinois、美国、61615
- Illinois CancerCare-Peoria
-
Peoria、Illinois、美国、61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru、Illinois、美国、61354
- Illinois CancerCare-Peru
-
Peru、Illinois、美国、61354
- Valley Radiation Oncology
-
Princeton、Illinois、美国、61356
- Illinois CancerCare-Princeton
-
Springfield、Illinois、美国、62702
- Southern Illinois University School of Medicine
-
Springfield、Illinois、美国、62702
- Springfield Clinic
-
Springfield、Illinois、美国、62781
- Springfield Memorial Hospital
-
Swansea、Illinois、美国、62226
- Southwest Illinois Health Services LLP
-
Urbana、Illinois、美国、61801
- Carle Cancer Center
-
Urbana、Illinois、美国、61801
- The Carle Foundation Hospital
-
Washington、Illinois、美国、61571
- Illinois CancerCare - Washington
-
Yorkville、Illinois、美国、60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Carmel、Indiana、美国、46032
- IU Health North Hospital
-
Indianapolis、Indiana、美国、46237
- Franciscan Health Indianapolis
-
Indianapolis、Indiana、美国、46202
- Indiana University/Melvin and Bren Simon Cancer Center
-
Indianapolis、Indiana、美国、46202
- Sidney and Lois Eskenazi Hospital
-
Indianapolis、Indiana、美国、46290
- Springmill Medical Center
-
Lafayette、Indiana、美国、47905
- Franciscan Saint Elizabeth Health - Lafayette East
-
Michigan City、Indiana、美国、46360
- Woodland Cancer Care Center
-
Mooresville、Indiana、美国、46158
- Franciscan Health Mooresville
-
New Albany、Indiana、美国、47150
- Baptist Health Floyd
-
Terre Haute、Indiana、美国、47804
- Union Hospital
-
-
Iowa
-
Bettendorf、Iowa、美国、52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Clive、Iowa、美国、50325
- Mercy Cancer Center-West Lakes
-
Clive、Iowa、美国、50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs、Iowa、美国、51503
- Alegent Health Mercy Hospital
-
Creston、Iowa、美国、50801
- Greater Regional Medical Center
-
Des Moines、Iowa、美国、50309
- Iowa Methodist Medical Center
-
Des Moines、Iowa、美国、50314
- Mercy Medical Center - Des Moines
-
Des Moines、Iowa、美国、50314
- Broadlawns Medical Center
-
Des Moines、Iowa、美国、50316
- Iowa Lutheran Hospital
-
Des Moines、Iowa、美国、50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines、Iowa、美国、50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge、Iowa、美国、50501
- UI Healthcare Mission Cancer and Blood - Fort Dodge
-
Iowa City、Iowa、美国、52242
- University of Iowa/Holden Comprehensive Cancer Center
-
West Des Moines、Iowa、美国、50266-7700
- Methodist West Hospital
-
West Des Moines、Iowa、美国、50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute、Kansas、美国、66720
- Cancer Center of Kansas - Chanute
-
Dodge City、Kansas、美国、67801
- Cancer Center of Kansas - Dodge City
-
El Dorado、Kansas、美国、67042
- Cancer Center of Kansas - El Dorado
-
Fairway、Kansas、美国、66205
- University of Kansas Clinical Research Center
-
Independence、Kansas、美国、67301
- Cancer Center of Kansas-Independence
-
Kingman、Kansas、美国、67068
- Cancer Center of Kansas-Kingman
-
Lawrence、Kansas、美国、66044
- Lawrence Memorial Hospital
-
Liberal、Kansas、美国、67905
- Cancer Center of Kansas-Liberal
-
Manhattan、Kansas、美国、66502
- Cancer Center of Kansas-Manhattan
-
McPherson、Kansas、美国、67460
- Cancer Center of Kansas - McPherson
-
Newton、Kansas、美国、67114
- Cancer Center of Kansas - Newton
-
Olathe、Kansas、美国、66061
- The University of Kansas Cancer Center - Olathe
-
Parsons、Kansas、美国、67357
- Cancer Center of Kansas - Parsons
-
Pittsburg、Kansas、美国、66762
- Mercy Hospital Pittsburg
-
Pratt、Kansas、美国、67124
- Cancer Center of Kansas - Pratt
-
Salina、Kansas、美国、67401
- Salina Regional Health Center
-
Salina、Kansas、美国、67401
- Cancer Center of Kansas - Salina
-
Topeka、Kansas、美国、66606
- University of Kansas Health System Saint Francis Campus
-
Wellington、Kansas、美国、67152
- Cancer Center of Kansas - Wellington
-
Westwood、Kansas、美国、66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita、Kansas、美国、67214
- Ascension Via Christi Hospitals Wichita
-
Wichita、Kansas、美国、67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita、Kansas、美国、67214
- Cancer Center of Kansas - Wichita
-
Winfield、Kansas、美国、67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown、Kentucky、美国、40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Corbin、Kentucky、美国、40701
- Baptist Health Corbin
-
Corbin、Kentucky、美国、40701
- Commonwealth Cancer Center-Corbin
-
Lexington、Kentucky、美国、40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington、Kentucky、美国、40503
- Baptist Health Lexington
-
Lexington、Kentucky、美国、40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
London、Kentucky、美国、40741
- CommonSpirit Saint Joseph Hospital London
-
Louisville、Kentucky、美国、40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville、Kentucky、美国、40202
- Jewish Hospital
-
Louisville、Kentucky、美国、40245
- UofL Health Medical Center Northeast
-
Louisville、Kentucky、美国、40207
- Baptist Health Louisville
-
Louisville、Kentucky、美国、40215
- Saints Mary and Elizabeth Hospital
-
Madisonville、Kentucky、美国、42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah、Kentucky、美国、42003
- Baptist Health Paducah
-
Shepherdsville、Kentucky、美国、40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge、Louisiana、美国、70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge、Louisiana、美国、70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge、Louisiana、美国、70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge、Louisiana、美国、70808
- Our Lady of the Lake Physician Group
-
Metairie、Louisiana、美国、70006
- East Jefferson General Hospital
-
New Orleans、Louisiana、美国、70112
- Louisiana State University Health Science Center
-
-
Maryland
-
Baltimore、Maryland、美国、21204
- Greater Baltimore Medical Center
-
-
Massachusetts
-
Boston、Massachusetts、美国、02215
- Beth Israel Deaconess Medical Center
-
Boston、Massachusetts、美国、02215
- Dana-Farber Cancer Institute
-
Boston、Massachusetts、美国、02118
- Boston Medical Center
-
Fitchburg、Massachusetts、美国、01420
- Simonds-Sinon Regional Cancer Center
-
Springfield、Massachusetts、美国、01104
- Mercy Medical Center
-
Worcester、Massachusetts、美国、01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Ann Arbor、Michigan、美国、48109
- University of Michigan Rogel Cancer Center
-
Ann Arbor、Michigan、美国、48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek、Michigan、美国、49017
- Bronson Battle Creek
-
Bay City、Michigan、美国、48706
- McLaren Cancer Institute-Bay City
-
Bloomfield、Michigan、美国、48302
- McLaren Cancer Institute-Bloomfield
-
Brighton、Michigan、美国、48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton、Michigan、美国、48116
- University of Michigan - Brighton Center for Specialty Care
-
Brighton、Michigan、美国、48114
- Trinity Health Medical Center - Brighton
-
Brownstown、Michigan、美国、48183
- Henry Ford Cancer Institute-Downriver
-
Canton、Michigan、美国、48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton、Michigan、美国、48188
- Trinity Health Medical Center - Canton
-
Caro、Michigan、美国、48723
- Caro Cancer Center
-
Chelsea、Michigan、美国、48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea、Michigan、美国、48118
- Chelsea Hospital
-
Clarkston、Michigan、美国、48346
- McLaren Cancer Institute-Clarkston
-
Clarkston、Michigan、美国、48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston、Michigan、美国、48346
- Newland Medical Associates-Clarkston
-
Clinton Township、Michigan、美国、48038
- Henry Ford Macomb Hospital-Clinton Township
-
Dearborn、Michigan、美国、48126
- Henry Ford Medical Center-Fairlane
-
Dearborn、Michigan、美国、48124
- Corewell Health Dearborn Hospital
-
Detroit、Michigan、美国、48202
- Henry Ford Hospital
-
Detroit、Michigan、美国、48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit、Michigan、美国、48236
- Henry Ford Health Saint John Hospital
-
East China Township、Michigan、美国、48054
- Henry Ford River District Hospital
-
Farmington Hills、Michigan、美国、48334
- Weisberg Cancer Treatment Center
-
Farmington Hills、Michigan、美国、48336
- Corewell Health Farmington Hills Hospital
-
Flint、Michigan、美国、48532
- McLaren Cancer Institute-Flint
-
Flint、Michigan、美国、48532
- Singh and Arora Hematology Oncology PC
-
Flint、Michigan、美国、48503
- Hurley Medical Center
-
Flint、Michigan、美国、48503
- Genesee Hematology Oncology PC
-
Flint、Michigan、美国、48503
- Genesys Hurley Cancer Institute
-
Flint、Michigan、美国、48503
- Cancer Hematology Centers - Flint
-
Grand Rapids、Michigan、美国、49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids、Michigan、美国、49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grand Rapids、Michigan、美国、49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
-
Grosse Pointe、Michigan、美国、48230
- William Beaumont Hospital-Grosse Pointe
-
Grosse Pointe Woods、Michigan、美国、48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods、Michigan、美国、48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods、Michigan、美国、48236
- Henry Ford Saint John Hospital - Van Elslander
-
Jackson、Michigan、美国、49201
- Allegiance Health
-
Kalamazoo、Michigan、美国、49007
- West Michigan Cancer Center
-
Kalamazoo、Michigan、美国、49007
- Bronson Methodist Hospital
-
Kalamazoo、Michigan、美国、49048
- Beacon Kalamazoo
-
Lansing、Michigan、美国、48912
- Mid-Michigan Physicians-Lansing
-
Lansing、Michigan、美国、48910
- Karmanos Cancer Institute at McLaren Greater Lansing
-
Lansing、Michigan、美国、48912
- University of Michigan Health - Sparrow Lansing
-
Lapeer、Michigan、美国、48446
- McLaren Cancer Institute-Lapeer Region
-
Livonia、Michigan、美国、48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia、Michigan、美国、48154
- Hope Cancer Clinic
-
Macomb、Michigan、美国、48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb、Michigan、美国、48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette、Michigan、美国、48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Mount Clemens、Michigan、美国、48043
- McLaren Cancer Institute-Macomb
-
Mount Pleasant、Michigan、美国、48858
- McLaren Cancer Institute-Central Michigan
-
Muskegon、Michigan、美国、49444
- Trinity Health Muskegon Hospital
-
Niles、Michigan、美国、49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Norton Shores、Michigan、美国、49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Novi、Michigan、美国、48377
- Henry Ford Medical Center-Columbus
-
Novi、Michigan、美国、48374
- Henry Ford Health Providence Novi Hospital
-
Petoskey、Michigan、美国、49770
- McLaren Cancer Institute-Northern Michigan
-
Pontiac、Michigan、美国、48341
- Hope Cancer Center
-
Pontiac、Michigan、美国、48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac、Michigan、美国、48341
- Michigan Healthcare Professionals Pontiac
-
Pontiac、Michigan、美国、48341
- Trinity Health IHA Medical Group-Alice Gustafson Center
-
Port Huron、Michigan、美国、48060
- McLaren-Port Huron
-
Reed City、Michigan、美国、49677
- Corewell Health Reed City Hospital
-
Rochester Hills、Michigan、美国、48309
- Henry Ford Rochester Hospital
-
Roseville、Michigan、美国、48066
- Michigan Cancer Specialists
-
Royal Oak、Michigan、美国、48073
- Cancer Care Associates PC
-
Royal Oak、Michigan、美国、48073
- Comprehensive Medical Center PLLC
-
Royal Oak、Michigan、美国、48073
- Oakland Medical Group
-
Royal Oak、Michigan、美国、48067
- Oakland Colon Rectal Associates
-
Royal Oak、Michigan、美国、48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak、Michigan、美国、48073
- Corewell Health William Beaumont University Hospital
-
Saginaw、Michigan、美国、48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw、Michigan、美国、48604
- Covenant HealthCare Mackinaw
-
Saginaw、Michigan、美国、48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph、Michigan、美国、49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph、Michigan、美国、49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Shelby、Michigan、美国、48315
- Henry Ford Macomb Health Center - Shelby Township
-
Southfield、Michigan、美国、48075
- Henry Ford Health Providence Southfield Hospital
-
Sterling Heights、Michigan、美国、48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Sterling Heights、Michigan、美国、48312
- Premier Hematology Oncology Care
-
Sterling Heights、Michigan、美国、48314
- Mitchell Folbe MD PC
-
Tawas City、Michigan、美国、48764
- MyMichigan Medical Center Tawas
-
Traverse City、Michigan、美国、49684
- Munson Medical Center
-
Troy、Michigan、美国、48084
- Michigan Institute of Urology-Town Center
-
Troy、Michigan、美国、48085
- Claudia BR Herke MD PC
-
Troy、Michigan、美国、48098
- Hematology Oncology Consultants PC-Troy
-
Troy、Michigan、美国、48085
- Corewell Health Beaumont Troy Hospital
-
Warren、Michigan、美国、48088
- Advanced Breast Care Center PLLC
-
Warren、Michigan、美国、48093
- Macomb Hematology Oncology PC
-
Warren、Michigan、美国、48093
- Henry Ford Madison Heights Hospital - Breast
-
Warren、Michigan、美国、48093
- Henry Ford Health Warren Hospital
-
Warren、Michigan、美国、48093
- Henry Ford Warren Hospital - GLCMS
-
West Bloomfield、Michigan、美国、48322
- Henry Ford West Bloomfield Hospital
-
West Branch、Michigan、美国、48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming、Michigan、美国、49519
- University of Michigan Health - West
-
Ypsilanti、Michigan、美国、48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti、Michigan、美国、48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin、Minnesota、美国、56431
- Riverwood Healthcare Center
-
Bemidji、Minnesota、美国、56601
- Sanford Joe Lueken Cancer Center
-
Brainerd、Minnesota、美国、56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville、Minnesota、美国、55337
- Fairview Ridges Hospital
-
Burnsville、Minnesota、美国、55337
- Minnesota Oncology - Burnsville
-
Cambridge、Minnesota、美国、55008
- Cambridge Medical Center
-
Coon Rapids、Minnesota、美国、55433
- Mercy Hospital
-
Deer River、Minnesota、美国、56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes、Minnesota、美国、56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth、Minnesota、美国、55805
- Essentia Health Cancer Center
-
Duluth、Minnesota、美国、55805
- Essentia Health Saint Mary's Medical Center
-
Duluth、Minnesota、美国、55805
- Miller-Dwan Hospital
-
Edina、Minnesota、美国、55435
- Fairview Southdale Hospital
-
Fergus Falls、Minnesota、美国、56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston、Minnesota、美国、56542
- Essentia Health - Fosston
-
Fridley、Minnesota、美国、55432
- Unity Hospital
-
Hibbing、Minnesota、美国、55746
- Essentia Health Hibbing Clinic
-
Maple Grove、Minnesota、美国、55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood、Minnesota、美国、55109
- Saint John's Hospital - Healtheast
-
Maplewood、Minnesota、美国、55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis、Minnesota、美国、55415
- Hennepin County Medical Center
-
Minneapolis、Minnesota、美国、55407
- Abbott-Northwestern Hospital
-
Minneapolis、Minnesota、美国、55454
- Health Partners Inc
-
Monticello、Minnesota、美国、55362
- Monticello Cancer Center
-
New Ulm、Minnesota、美国、56073
- New Ulm Medical Center
-
Park Rapids、Minnesota、美国、56470
- Essentia Health - Park Rapids
-
Princeton、Minnesota、美国、55371
- Fairview Northland Medical Center
-
Robbinsdale、Minnesota、美国、55422
- North Memorial Medical Health Center
-
Rochester、Minnesota、美国、55905
- Mayo Clinic in Rochester
-
Saint Louis Park、Minnesota、美国、55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul、Minnesota、美国、55101
- Regions Hospital
-
Saint Paul、Minnesota、美国、55102
- United Hospital
-
Sandstone、Minnesota、美国、55072
- Essentia Health Sandstone
-
Shakopee、Minnesota、美国、55379
- Saint Francis Regional Medical Center
-
Stillwater、Minnesota、美国、55082
- Lakeview Hospital
-
Thief River Falls、Minnesota、美国、56701
- Sanford Thief River Falls Medical Center
-
Virginia、Minnesota、美国、55792
- Essentia Health Virginia Clinic
-
Waconia、Minnesota、美国、55387
- Ridgeview Medical Center
-
Willmar、Minnesota、美国、56201
- Rice Memorial Hospital
-
Woodbury、Minnesota、美国、55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington、Minnesota、美国、56187
- Sanford Cancer Center Worthington
-
Wyoming、Minnesota、美国、55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Grenada、Mississippi、美国、38901
- Baptist Cancer Center-Grenada
-
New Albany、Mississippi、美国、38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford、Mississippi、美国、38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Southhaven、Mississippi、美国、38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin、Missouri、美国、63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bonne Terre、Missouri、美国、63628
- Parkland Health Center-Bonne Terre
-
Branson、Missouri、美国、65616
- Cox Cancer Center Branson
-
Cape Girardeau、Missouri、美国、63703
- Saint Francis Medical Center
-
Cape Girardeau、Missouri、美国、63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield、Missouri、美国、63017
- Saint Luke's Hospital
-
City of Saint Peters、Missouri、美国、63376
- Siteman Cancer Center at Saint Peters Hospital
-
Creve Coeur、Missouri、美国、63141
- Siteman Cancer Center at West County Hospital
-
Farmington、Missouri、美国、63640
- Parkland Health Center - Farmington
-
Jefferson City、Missouri、美国、65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin、Missouri、美国、64804
- Freeman Health System
-
Joplin、Missouri、美国、64804
- Mercy Hospital Joplin
-
Rolla、Missouri、美国、65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla、Missouri、美国、65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph、Missouri、美国、64506
- Heartland Regional Medical Center
-
Sainte Genevieve、Missouri、美国、63670
- Sainte Genevieve County Memorial Hospital
-
Springfield、Missouri、美国、65807
- CoxHealth South Hospital
-
Springfield、Missouri、美国、65804
- Mercy Hospital Springfield
-
St Louis、Missouri、美国、63110
- Washington University School of Medicine
-
St Louis、Missouri、美国、63129
- Siteman Cancer Center-South County
-
St Louis、Missouri、美国、63131
- Missouri Baptist Medical Center
-
St Louis、Missouri、美国、63109
- Mercy Infusion Center - Chippewa
-
St Louis、Missouri、美国、63141
- Mercy Hospital Saint Louis
-
St Louis、Missouri、美国、63128
- Mercy Hospital South
-
Sullivan、Missouri、美国、63080
- Missouri Baptist Sullivan Hospital
-
Washington、Missouri、美国、63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda、Montana、美国、59711
- Community Hospital of Anaconda
-
Billings、Montana、美国、59101
- Billings Clinic Cancer Center
-
Billings、Montana、美国、59101
- Saint Vincent Healthcare
-
Billings、Montana、美国、59102
- Saint Vincent Frontier Cancer Center
-
Bozeman、Montana、美国、59715
- Bozeman Health Deaconess Hospital
-
Butte、Montana、美国、59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls、Montana、美国、59405
- Great Falls Clinic
-
Great Falls、Montana、美国、59405
- Benefis Sletten Cancer Institute
-
Helena、Montana、美国、59601
- Saint Peter's Community Hospital
-
Kalispell、Montana、美国、59901
- Logan Health Medical Center
-
Missoula、Montana、美国、59802
- Saint Patrick Hospital - Community Hospital
-
Missoula、Montana、美国、59804
- Community Medical Center
-
-
Nebraska
-
Grand Island、Nebraska、美国、68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney、Nebraska、美国、68847
- CHI Health Good Samaritan
-
Kearney、Nebraska、美国、68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln、Nebraska、美国、68510
- Saint Elizabeth Regional Medical Center
-
Omaha、Nebraska、美国、68114
- Nebraska Methodist Hospital
-
Omaha、Nebraska、美国、68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha、Nebraska、美国、68122
- Alegent Health Immanuel Medical Center
-
Omaha、Nebraska、美国、68130
- Alegent Health Lakeside Hospital
-
Omaha、Nebraska、美国、68122
- Hematology and Oncology Consultants PC
-
Papillion、Nebraska、美国、68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City、Nevada、美国、89703
- Carson Tahoe Regional Medical Center
-
Henderson、Nevada、美国、89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson、Nevada、美国、89052
- Cancer and Blood Specialists-Henderson
-
Henderson、Nevada、美国、89052
- Las Vegas Cancer Center-Henderson
-
Henderson、Nevada、美国、89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson、Nevada、美国、89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson、Nevada、美国、89074
- Las Vegas Urology - Green Valley
-
Henderson、Nevada、美国、89074
- Las Vegas Urology - Pebble
-
Henderson、Nevada、美国、89074
- Urology Specialists of Nevada - Green Valley
-
Henderson、Nevada、美国、89074
- Oncology Las Vegas - Henderson
-
Las Vegas、Nevada、美国、89144
- Summerlin Hospital Medical Center
-
Las Vegas、Nevada、美国、89109
- Sunrise Hospital and Medical Center
-
Las Vegas、Nevada、美国、89102
- OptumCare Cancer Care at Charleston
-
Las Vegas、Nevada、美国、89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas、Nevada、美国、89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas、Nevada、美国、89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas、Nevada、美国、89128
- OptumCare Cancer Care at MountainView
-
Las Vegas、Nevada、美国、89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas、Nevada、美国、89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas、Nevada、美国、89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas、Nevada、美国、89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas、Nevada、美国、89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas、Nevada、美国、89102
- University Medical Center of Southern Nevada
-
Las Vegas、Nevada、美国、89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas、Nevada、美国、89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas、Nevada、美国、89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas、Nevada、美国、89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas、Nevada、美国、89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas、Nevada、美国、89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas、Nevada、美国、89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas、Nevada、美国、89128
- Ann M Wierman MD LTD
-
Las Vegas、Nevada、美国、89074
- Las Vegas Urology - Pecos
-
Las Vegas、Nevada、美国、89102
- Desert West Surgery
-
Las Vegas、Nevada、美国、89103
- Hope Cancer Care of Nevada
-
Las Vegas、Nevada、美国、89106
- Urology Specialists of Nevada - Central
-
Las Vegas、Nevada、美国、89113
- Las Vegas Prostate Cancer Center
-
Las Vegas、Nevada、美国、89113
- Las Vegas Urology - Sunset
-
Las Vegas、Nevada、美国、89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas、Nevada、美国、89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas、Nevada、美国、89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas、Nevada、美国、89169
- University Cancer Center
-
Las Vegas、Nevada、美国、89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas、Nevada、美国、89128
- Oncology Las Vegas - Tenaya
-
Las Vegas、Nevada、美国、89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump、Nevada、美国、89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno、Nevada、美国、89502
- Renown Regional Medical Center
-
Reno、Nevada、美国、89503
- Saint Mary's Regional Medical Center
-
Reno、Nevada、美国、89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Lebanon、New Hampshire、美国、03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
-
New Jersey
-
Basking Ridge、New Jersey、美国、07920
- Memorial Sloan Kettering Basking Ridge
-
Middletown、New Jersey、美国、07748
- Memorial Sloan Kettering Monmouth
-
Montvale、New Jersey、美国、07645
- Memorial Sloan Kettering Bergen
-
Moorestown、New Jersey、美国、08057
- Virtua Samson Cancer Center
-
Morristown、New Jersey、美国、07960
- Morristown Medical Center
-
Mount Holly、New Jersey、美国、08060
- Virtua Memorial
-
New Brunswick、New Jersey、美国、08903
- Rutgers Cancer Institute of New Jersey
-
Summit、New Jersey、美国、07902
- Overlook Hospital
-
Teaneck、New Jersey、美国、07666
- Holy Name Hospital
-
Voorhees Township、New Jersey、美国、08043
- Virtua Voorhees
-
-
New Mexico
-
Albuquerque、New Mexico、美国、87102
- Lovelace Medical Center-Saint Joseph Square
-
Albuquerque、New Mexico、美国、87109
- Lovelace Radiation Oncology
-
Albuquerque、New Mexico、美国、87106
- University of New Mexico Cancer Center
-
Albuquerque、New Mexico、美国、87110
- Presbyterian Kaseman Hospital
-
Rio Rancho、New Mexico、美国、87124
- Presbyterian Rust Medical Center/Jorgensen Cancer Center
-
-
New York
-
Buffalo、New York、美国、14263
- Roswell Park Cancer Institute
-
Commack、New York、美国、11725
- Memorial Sloan Kettering Commack
-
Glens Falls、New York、美国、12801
- Glens Falls Hospital
-
Harrison、New York、美国、10604
- Memorial Sloan Kettering Westchester
-
New York、New York、美国、10065
- Memorial Sloan Kettering Cancer Center
-
New York、New York、美国、10019
- Mount Sinai West
-
New York、New York、美国、10029
- Mount Sinai Hospital
-
New York、New York、美国、10075
- Lenox Hill Hospital
-
New York、New York、美国、10065
- Manhattan Eye Ear and Throat Hospital
-
The Bronx、New York、美国、10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx、New York、美国、10467
- Montefiore Medical Center - Moses Campus
-
The Bronx、New York、美国、10461
- Montefiore Medical Center-Weiler Hospital
-
Uniondale、New York、美国、11553
- Memorial Sloan Kettering Nassau
-
-
North Carolina
-
Albemarle、North Carolina、美国、28002
- Atrium Health Stanly/LCI-Albemarle
-
Chapel Hill、North Carolina、美国、27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte、North Carolina、美国、28203
- Carolinas Medical Center/Levine Cancer Institute
-
Charlotte、North Carolina、美国、28210
- Atrium Health Pineville/LCI-Pineville
-
Charlotte、North Carolina、美国、28262
- Atrium Health University City/LCI-University
-
Charlotte、North Carolina、美国、28211
- Levine Cancer Institute-SouthPark
-
Charlotte、North Carolina、美国、28277
- Levine Cancer Institute-Ballantyne
-
Clemmons、North Carolina、美国、27012
- Wake Forest University at Clemmons
-
Clinton、North Carolina、美国、28328
- Southeastern Medical Oncology Center-Clinton
-
Concord、North Carolina、美国、28025
- Atrium Health Cabarrus/LCI-Concord
-
Elkin、North Carolina、美国、28521
- Wake Forest University at Elkin
-
Gastonia、North Carolina、美国、28054
- Levine Cancer Institute-Gaston
-
Goldsboro、North Carolina、美国、27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro、North Carolina、美国、27534
- Wayne Memorial Hospital
-
Hendersonville、North Carolina、美国、28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville、North Carolina、美国、28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville、North Carolina、美国、28546
- Onslow Memorial Hospital
-
Kenansville、North Carolina、美国、28349
- ECU Health Oncology Kenansville
-
Kinston、North Carolina、美国、28501
- ECU Health Oncology Kinston
-
Lexington、North Carolina、美国、27292
- Wake Forest University at Lexington
-
Lincolnton、North Carolina、美国、28092
- Atrium Health Lincoln/LCI-Lincolnton
-
Monroe、North Carolina、美国、28112
- Atrium Health Union/LCI-Union
-
Mount Airy、North Carolina、美国、27030
- Wake Forest University at Mount Airy
-
Raleigh、North Carolina、美国、27607
- Rex Hematology Oncology Associates-Blue Ridge
-
Raleigh、North Carolina、美国、27607
- UNC Health Cancer Care Raleigh
-
Raleigh、North Carolina、美国、27614
- UNC Health Cancer Care Wakefield
-
Richlands、North Carolina、美国、28574
- ECU Health Oncology Richlands
-
Winston-Salem、North Carolina、美国、27157
- Wake Forest University Health Sciences
-
-
North Dakota
-
Bismarck、North Dakota、美国、58501
- Sanford Bismarck Medical Center
-
Fargo、North Dakota、美国、58122
- Sanford Roger Maris Cancer Center
-
Fargo、North Dakota、美国、58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo、North Dakota、美国、58122
- Sanford Broadway Medical Center
-
Fargo、North Dakota、美国、58103
- Sanford South University Medical Center
-
Jamestown、North Dakota、美国、58401
- Essentia Health - Jamestown Clinic
-
Minot、North Dakota、美国、58701
- Trinity Cancer Care Center
-
-
Ohio
-
Beachwood、Ohio、美国、44122
- UHHS-Chagrin Highlands Medical Center
-
Belpre、Ohio、美国、45714
- Strecker Cancer Center-Belpre
-
Chardon、Ohio、美国、44024
- Geauga Hospital
-
Chillicothe、Ohio、美国、45601
- Adena Regional Medical Center
-
Cincinnati、Ohio、美国、45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati、Ohio、美国、45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati、Ohio、美国、45242
- Bethesda North Hospital
-
Cincinnati、Ohio、美国、45247
- TriHealth Cancer Institute-Westside
-
Cincinnati、Ohio、美国、45255
- TriHealth Cancer Institute-Anderson
-
Cleveland、Ohio、美国、44106
- Case Western Reserve University
-
Cleveland、Ohio、美国、44109
- MetroHealth Medical Center
-
Columbus、Ohio、美国、43214
- Riverside Methodist Hospital
-
Columbus、Ohio、美国、43210
- Ohio State University Comprehensive Cancer Center
-
Columbus、Ohio、美国、43219
- The Mark H Zangmeister Center
-
Columbus、Ohio、美国、43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus、Ohio、美国、43228
- Doctors Hospital
-
Columbus、Ohio、美国、43213
- Mount Carmel East Hospital
-
Columbus、Ohio、美国、43215
- Grant Medical Center
-
Columbus、Ohio、美国、43222
- Mount Carmel Health Center West
-
Delaware、Ohio、美国、43015
- Delaware Health Center-Grady Cancer Center
-
Delaware、Ohio、美国、43015
- Delaware Radiation Oncology
-
Delaware、Ohio、美国、43015
- Grady Memorial Hospital
-
Dublin、Ohio、美国、43016
- Dublin Methodist Hospital
-
Elyria、Ohio、美国、44035
- Mercy Cancer Center-Elyria
-
Grove City、Ohio、美国、43123
- Mount Carmel Grove City Hospital
-
Lancaster、Ohio、美国、43130
- Fairfield Medical Center
-
Mansfield、Ohio、美国、44903
- OhioHealth Mansfield Hospital
-
Marietta、Ohio、美国、45750
- Marietta Memorial Hospital
-
Marion、Ohio、美国、43302
- OhioHealth Marion General Hospital
-
Mayfield Heights、Ohio、美国、44124
- UH Seidman Cancer Center at Landerbrook Health Center
-
Mentor、Ohio、美国、44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights、Ohio、美国、44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Mount Vernon、Ohio、美国、43050
- Knox Community Hospital
-
Newark、Ohio、美国、43055
- Licking Memorial Hospital
-
Newark、Ohio、美国、43055
- Newark Radiation Oncology
-
Parma、Ohio、美国、44129
- University Hospitals Parma Medical Center
-
Portsmouth、Ohio、美国、45662
- Southern Ohio Medical Center
-
Ravenna、Ohio、美国、44266
- University Hospitals Portage Medical Center
-
Sandusky、Ohio、美国、44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Wadsworth、Ohio、美国、44281
- University Hospitals Sharon Health Center
-
West Chester、Ohio、美国、45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville、Ohio、美国、43081
- Saint Ann's Hospital
-
Westlake、Ohio、美国、44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Westlake、Ohio、美国、44145
- UHHS-Westlake Medical Center
-
Zanesville、Ohio、美国、43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton、Oklahoma、美国、73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City、Oklahoma、美国、73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City、Oklahoma、美国、73120
- Mercy Hospital Oklahoma City
-
Tulsa、Oklahoma、美国、74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City、Oregon、美国、97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend、Oregon、美国、97701
- Saint Charles Health System
-
Clackamas、Oregon、美国、97015
- Clackamas Radiation Oncology Center
-
Clackamas、Oregon、美国、97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay、Oregon、美国、97420
- Bay Area Hospital
-
Newberg、Oregon、美国、97132
- Providence Newberg Medical Center
-
Ontario、Oregon、美国、97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Portland、Oregon、美国、97239
- Oregon Health and Science University
-
Portland、Oregon、美国、97213
- Providence Portland Medical Center
-
Portland、Oregon、美国、97225
- Providence Saint Vincent Medical Center
-
Portland、Oregon、美国、97227
- Kaiser Permanente Northwest
-
Redmond、Oregon、美国、97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Abington、Pennsylvania、美国、19001
- Jefferson Abington Hospital
-
Allentown、Pennsylvania、美国、18103
- Lehigh Valley Hospital-Cedar Crest
-
Beaver、Pennsylvania、美国、15009
- UPMC-Heritage Valley Health System Beaver
-
Bethlehem、Pennsylvania、美国、18017
- Lehigh Valley Hospital - Muhlenberg
-
Bethlehem、Pennsylvania、美国、18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Bryn Mawr、Pennsylvania、美国、19010
- Bryn Mawr Hospital
-
Chadds Ford、Pennsylvania、美国、19317
- Christiana Care Health System-Concord Health Center
-
Collegeville、Pennsylvania、美国、19426
- Main Line Health Center-Collegeville
-
Danville、Pennsylvania、美国、17822
- Geisinger Medical Center
-
East Stroudsburg、Pennsylvania、美国、18301
- Pocono Medical Center
-
Exton、Pennsylvania、美国、19341
- Main Line Health Center-Exton
-
Greensburg、Pennsylvania、美国、15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Harrisburg、Pennsylvania、美国、17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Harrisburg、Pennsylvania、美国、17101
- UPMC Pinnacle Harrisburg
-
Hazleton、Pennsylvania、美国、18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton、Pennsylvania、美国、18201
- Lehigh Valley Hospital-Hazleton
-
Johnstown、Pennsylvania、美国、15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg、Pennsylvania、美国、17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown、Pennsylvania、美国、17044
- Lewistown Hospital
-
McKeesport、Pennsylvania、美国、15132
- UPMC Cancer Center at UPMC McKeesport
-
Media、Pennsylvania、美国、19063
- Riddle Memorial Hospital
-
Moon Township、Pennsylvania、美国、15108
- UPMC Hillman Cancer Center in Coraopolis
-
Paoli、Pennsylvania、美国、19301
- Paoli Memorial Hospital
-
Philadelphia、Pennsylvania、美国、19111
- Fox Chase Cancer Center
-
Philadelphia、Pennsylvania、美国、19107
- Thomas Jefferson University Hospital
-
Philadelphia、Pennsylvania、美国、19114
- Jefferson Torresdale Hospital
-
Philadelphia、Pennsylvania、美国、19104
- University of Pennsylvania/Abramson Cancer Center
-
Philadelphia、Pennsylvania、美国、19140
- Temple University Hospital
-
Philadelphia、Pennsylvania、美国、19107
- Pennsylvania Hospital
-
Pittsburgh、Pennsylvania、美国、15232
- UPMC Hillman Cancer Center
-
Pittsburgh、Pennsylvania、美国、15213
- UPMC-Magee Womens Hospital
-
Pittsburgh、Pennsylvania、美国、15232
- UPMC-Shadyside Hospital
-
Pittsburgh、Pennsylvania、美国、15215
- UPMC-Saint Margaret
-
Pittsburgh、Pennsylvania、美国、15237
- UPMC-Passavant Hospital
-
Pittsburgh、Pennsylvania、美国、15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville、Pennsylvania、美国、17901
- Geisinger Cancer Services-Pottsville
-
Seneca、Pennsylvania、美国、16346
- UPMC Cancer Center at UPMC Northwest
-
State College、Pennsylvania、美国、16801
- Geisinger Medical Group
-
Uniontown、Pennsylvania、美国、15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington、Pennsylvania、美国、15301
- UPMC Washington Hospital Radiation Oncology
-
West Reading、Pennsylvania、美国、19611
- Reading Hospital
-
Wilkes-Barre、Pennsylvania、美国、18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Willow Grove、Pennsylvania、美国、19090
- Asplundh Cancer Pavilion
-
Wynnewood、Pennsylvania、美国、19096
- Lankenau Medical Center
-
York、Pennsylvania、美国、17408
- UPMC Memorial
-
-
South Carolina
-
Boiling Springs、South Carolina、美国、29316
- Prisma Health Cancer Institute - Spartanburg
-
Clinton、South Carolina、美国、29325
- Prisma Health Cancer Institute - Laurens
-
Easley、South Carolina、美国、29640
- Prisma Health Cancer Institute - Easley
-
Gaffney、South Carolina、美国、29341
- Gibbs Cancer Center-Gaffney
-
Georgetown、South Carolina、美国、29440
- Tidelands Georgetown Memorial Hospital
-
Greenville、South Carolina、美国、29605
- Prisma Health Cancer Institute - Faris
-
Greenville、South Carolina、美国、29615
- Prisma Health Cancer Institute - Eastside
-
Greenville、South Carolina、美国、29605
- Prisma Health Cancer Institute - Butternut
-
Greenville、South Carolina、美国、29605
- Prisma Health Greenville Memorial Hospital
-
Greer、South Carolina、美国、29650
- Prisma Health Cancer Institute - Greer
-
Greer、South Carolina、美国、29651
- Gibbs Cancer Center-Pelham
-
Rock Hill、South Carolina、美国、29732
- Levine Cancer Institute-Rock Hill
-
Rock Hill、South Carolina、美国、29730
- Rock Hill Radiation Therapy Center
-
Seneca、South Carolina、美国、29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg、South Carolina、美国、29303
- Spartanburg Medical Center
-
Union、South Carolina、美国、29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Sioux Falls、South Dakota、美国、57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls、South Dakota、美国、57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga、Tennessee、美国、37404
- Memorial Hospital
-
Collierville、Tennessee、美国、38017
- Baptist Memorial Hospital and Cancer Center-Collierville
-
Franklin、Tennessee、美国、37067
- Vanderbilt-Ingram Cancer Center Cool Springs
-
Hixson、Tennessee、美国、37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Memphis、Tennessee、美国、38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
Nashville、Tennessee、美国、37232
- Vanderbilt University/Ingram Cancer Center
-
Nashville、Tennessee、美国、37204
- Vanderbilt Breast Center at One Hundred Oaks
-
Ooltewah、Tennessee、美国、37363
- Memorial GYN Plus
-
-
Texas
-
Bryan、Texas、美国、77802
- Saint Joseph Regional Cancer Center
-
Dallas、Texas、美国、75235
- Parkland Memorial Hospital
-
Dallas、Texas、美国、75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Worth、Texas、美国、76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Houston、Texas、美国、77030
- UT MD Anderson Cancer Center
-
Richardson、Texas、美国、75080
- UT Southwestern Clinical Center at Richardson/Plano
-
-
Utah
-
American Fork、Utah、美国、84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City、Utah、美国、84720
- Sandra L Maxwell Cancer Center
-
Farmington、Utah、美国、84025
- Farmington Health Center
-
Logan、Utah、美国、84321
- Logan Regional Hospital
-
Murray、Utah、美国、84107
- Intermountain Medical Center
-
Ogden、Utah、美国、84403
- McKay-Dee Hospital Center
-
Provo、Utah、美国、84604
- Utah Valley Regional Medical Center
-
Riverton、Utah、美国、84065
- Riverton Hospital
-
Salt Lake City、Utah、美国、84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City、Utah、美国、84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City、Utah、美国、84143
- LDS Hospital
-
Salt Lake City、Utah、美国、84106
- University of Utah Sugarhouse Health Center
-
St. George、Utah、美国、84770
- Saint George Regional Medical Center
-
-
Vermont
-
Berlin Corners、Vermont、美国、05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington、Vermont、美国、05401
- University of Vermont Medical Center
-
Burlington、Vermont、美国、05405
- University of Vermont and State Agricultural College
-
Saint Johnsbury、Vermont、美国、05819
- Dartmouth Cancer Center - North
-
-
Virginia
-
Martinsville、Virginia、美国、24112
- Sovah Health Martinsville
-
Richmond、Virginia、美国、23298
- VCU Massey Comprehensive Cancer Center
-
South Hill、Virginia、美国、23970
- VCU Community Memorial Health Center
-
-
Washington
-
Aberdeen、Washington、美国、98520
- Providence Regional Cancer System-Aberdeen
-
Auburn、Washington、美国、98001
- MultiCare Auburn Medical Center
-
Bellevue、Washington、美国、98004
- Overlake Medical Center
-
Bellingham、Washington、美国、98225
- PeaceHealth Saint Joseph Medical Center
-
Burien、Washington、美国、98166
- Saint Anne Hospital
-
Centralia、Washington、美国、98531
- Providence Regional Cancer System-Centralia
-
Edmonds、Washington、美国、98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw、Washington、美国、98022
- Saint Elizabeth Hospital
-
Everett、Washington、美国、98201
- Providence Regional Cancer Partnership
-
Federal Way、Washington、美国、98003
- Saint Francis Hospital
-
Gig Harbor、Washington、美国、98335
- MultiCare Gig Harbor Medical Park
-
Issaquah、Washington、美国、98029
- Swedish Cancer Institute-Issaquah
-
Kennewick、Washington、美国、99336
- Kadlec Clinic Hematology and Oncology
-
Lacey、Washington、美国、98503
- Providence Regional Cancer System-Lacey
-
Lakewood、Washington、美国、98499
- Saint Clare Hospital
-
Longview、Washington、美国、98632
- PeaceHealth Saint John Medical Center
-
Port Townsend、Washington、美国、98368
- Jefferson Healthcare
-
Poulsbo、Washington、美国、98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup、Washington、美国、98372
- MultiCare Good Samaritan Hospital
-
Renton、Washington、美国、98055
- Valley Medical Center
-
Seattle、Washington、美国、98107
- Swedish Medical Center-Ballard Campus
-
Seattle、Washington、美国、98122
- Swedish Medical Center-First Hill
-
Seattle、Washington、美国、98195
- University of Washington Medical Center - Montlake
-
Seattle、Washington、美国、98112
- Kaiser Permanente Washington
-
Seattle、Washington、美国、98104
- Pacific Gynecology Specialists
-
Seattle、Washington、美国、98122-5711
- Swedish Medical Center-Cherry Hill
-
Seattle、Washington、美国、98109
- Fred Hutchinson Cancer Center
-
Sedro-Woolley、Washington、美国、98284
- PeaceHealth United General Medical Center
-
Shelton、Washington、美国、98584
- Providence Regional Cancer System-Shelton
-
Silverdale、Washington、美国、98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane、Washington、美国、99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane、Washington、美国、99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley、Washington、美国、99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma、Washington、美国、98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma、Washington、美国、98405
- Northwest Medical Specialties PLLC
-
Tacoma、Washington、美国、98405
- MultiCare Tacoma General Hospital
-
Tacoma、Washington、美国、98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver、Washington、美国、98664
- PeaceHealth Southwest Medical Center
-
Walla Walla、Washington、美国、99362
- Providence Saint Mary Regional Cancer Center
-
Yelm、Washington、美国、98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Bridgeport、West Virginia、美国、26330
- United Hospital Center
-
Charleston、West Virginia、美国、25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
Martinsburg、West Virginia、美国、25401
- WVUH-Berkely Medical Center
-
Morgantown、West Virginia、美国、26506
- West Virginia University Healthcare
-
Parkersburg、West Virginia、美国、26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Appleton、Wisconsin、美国、54911
- ThedaCare Regional Cancer Center
-
Ashland、Wisconsin、美国、54806
- Duluth Clinic Ashland
-
Ashland、Wisconsin、美国、54806
- Northwest Wisconsin Cancer Center
-
Burlington、Wisconsin、美国、53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Eau Claire、Wisconsin、美国、54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire、Wisconsin、美国、54701
- HSHS Sacred Heart Hospital
-
Fond du Lac、Wisconsin、美国、54937
- Aurora Health Center-Fond du Lac
-
Germantown、Wisconsin、美国、53022
- Aurora Health Care Germantown Health Center
-
Grafton、Wisconsin、美国、53024
- Aurora Cancer Care-Grafton
-
Green Bay、Wisconsin、美国、54311
- Aurora BayCare Medical Center
-
Green Bay、Wisconsin、美国、54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay、Wisconsin、美国、54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay、Wisconsin、美国、54301
- Bellin Memorial Hospital
-
Johnson Creek、Wisconsin、美国、53038
- University of Wisconsin Carbone Cancer Center - Johnson Creek
-
Kenosha、Wisconsin、美国、53142
- Aurora Cancer Care-Kenosha South
-
La Crosse、Wisconsin、美国、54601
- Gundersen Lutheran Medical Center
-
Madison、Wisconsin、美国、53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Marinette、Wisconsin、美国、54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield、Wisconsin、美国、54449
- Marshfield Medical Center-Marshfield
-
Milwaukee、Wisconsin、美国、53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee、Wisconsin、美国、53215
- Aurora Saint Luke's Medical Center
-
Milwaukee、Wisconsin、美国、53233
- Aurora Sinai Medical Center
-
Minocqua、Wisconsin、美国、54548
- Marshfield Medical Center - Minocqua
-
Mukwonago、Wisconsin、美国、53149
- ProHealth D N Greenwald Center
-
New Richmond、Wisconsin、美国、54017
- Cancer Center of Western Wisconsin
-
Oconomowoc、Wisconsin、美国、53066
- ProHealth Oconomowoc Memorial Hospital
-
Oshkosh、Wisconsin、美国、54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine、Wisconsin、美国、53406
- Aurora Cancer Care-Racine
-
Rice Lake、Wisconsin、美国、54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan、Wisconsin、美国、53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point、Wisconsin、美国、54482
- Marshfield Medical Center-River Region at Stevens Point
-
Sturgeon Bay、Wisconsin、美国、54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit、Wisconsin、美国、53066
- Aurora Medical Center in Summit
-
Two Rivers、Wisconsin、美国、54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha、Wisconsin、美国、53188
- UW Cancer Center at ProHealth Care
-
Waukesha、Wisconsin、美国、53188
- ProHealth Waukesha Memorial Hospital
-
Wausau、Wisconsin、美国、54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa、Wisconsin、美国、53226
- Aurora Cancer Care-Milwaukee West
-
West Allis、Wisconsin、美国、53227
- Aurora West Allis Medical Center
-
Weston、Wisconsin、美国、54476
- Marshfield Medical Center - Weston
-
-
Wyoming
-
Cheyenne、Wyoming、美国、82001
- Cheyenne Regional Medical Center-West
-
Cody、Wyoming、美国、82414
- Billings Clinic-Cody
-
Sheridan、Wyoming、美国、82801
- Welch Cancer Center
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
资格标准
适合学习的年龄
18年 及以上 (成人、年长者)
接受健康志愿者
不
有资格学习的性别
全部
描述
Inclusion Criteria:
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Age >= 18 years
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must have histologically proven stage IIB (T3N0M0 only), IIIA (T2N1M0), IIIB (T4N0M0), or IIIC (T3N1M0, T4N1M0) invasive squamous cell carcinoma of the anus or anorectum, according to the American Joint Committee on Cancer (AJCC) 8th edition; this may include tumors of non-keratinizing histology such as basaloid, transitional cell, or cloacogenic histology; individuals with squamous cell carcinoma of the anal margin are eligible if there is evidence of extension of the primary tumor into the anal canal
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must have Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must have hemoglobin levels of > 9 g/dL (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patient must have a platelet count of > 100,000/mm^3 (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patient's absolute neutrophil count (ANC) level must be > 1500/mm^3 (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Serum creatinine must be =< 1.5 X upper limit of normal (ULN) (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Total bilirubin must be < 2 X ULN (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT]) =< 2.5 X institutional upper limit of normal (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Albumin >= 3.0 g/dL (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients known to be human immunodeficiency virus (HIV)+ are permitted; patients with CD4 > 200 and serum HIV viral load of < 200 copies/mm^3 are eligible, and in addition:
- Participants must be purified protein derivative (PPD) negative; alternatively, the QuantiFERON-tuberculosis (TB) Gold In-Tube (QFT-GIT) assay (Cellestis Limited, Carnegie, Australia) can be used; an individual is considered positive for M. tuberculosis infection if the IFN-gamma response to TB antigens is above the test cut-off (after subtracting the background IFN-gamma response in the negative control); the result must be obtained within 20 weeks prior to enrollment; PPD positive (or Quantiferon assay positive) participants are permitted if prophylaxis has been completed prior to enrollment
- No history of acquired immune deficiency syndrome (AIDS)-related complications within past year other than a history of low CD4+ T-cell count > 200/mm^3 prior to initiation of combination antiretroviral therapy; on study CD4+ T-cell count may not be informative due to chemoradiotherapy and should not be used as an exclusion criterion if low
- Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the anal cancer
- Participants MUST receive appropriate care and treatment for HIV infection, including antiretroviral medications when clinically indicated, and should be under the care of a physician experienced in HIV management; participants will be eligible regardless of antiretroviral medication (including no antiretroviral medication) provided there is no intention to initiate therapy or the regimen has been stable for at least 4 weeks with no intention to change the regimen within 12 weeks following enrollment
- Patient must have =< grade 2 diarrhea (participants with grade 1 diarrhea are eligible provided stool for ova/parasites and stool cryptosporidium studies are negative;
- NOTE: HIV testing is not required for eligibility
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: For patients registering prior to start of chemoradiotherapy, baseline scans must have been completed within 4 weeks prior to registration
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Women of child bearing potential and sexually active males must use accepted and effective method(s) of contraception and/or abstain from sexual intercourse while on protocol treatment and for at least 5 months after the last dose of nivolumab (for female patients) and for at least 7 months after the last dose of nivolumab (for male patients)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Any surgery must have been completed >= 4 weeks prior to starting study treatment
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No prior treatment with an immune checkpoint inhibitor (anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA4 monoclonal antibody)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No patients with immunodeficiency or receiving systemic steroid therapy equivalent to > 10 mg prednisone per day or any other form of immunosuppressive therapy within 7 days prior to Step 1 registration; topical corticosteroid or occasional inhaled corticosteroids are allowed
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: No live vaccines within 30 days prior to registration; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, BCG, and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines and are not allowed
- NOTE: no live vaccines may be administered while participating in the trial
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Previously irradiated patients (Arm S) must have received radiation per National Comprehensive Cancer Network guidelines; radiation therapy delivered on protocol (Arm T) will be reviewed
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients will be registered within 63 days following completion of standard chemoradiation for anal cancer; standard chemoradiation therapy is as defined
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have histologically proven stage IIB (T3N0M0 only), IIIA (T2N1M0), IIIB (T4N0M0), or IIIC (T3N1M0, T4N1M0) invasive squamous cell carcinoma of the anus or anorectum, according to the AJCC 8th edition; this may include tumors of non-keratinizing histology such as basaloid, transitional cell, or cloacogenic histology; individuals with squamous cell carcinoma of the anal margin are eligible if there is evidence of extension of the primary tumor into the anal canal
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have received at least 54 gray (Gy) of radiation to the PTVp (primary) and 45 Gy to PTVn (elective nodal region) for the treatment of the anal cancer
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have ECOG performance status of 0-2
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have hemoglobin levels of > 10 g/dL (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient must have a platelet count of > 100,000/mm^3 (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient's ANC level must be > 1500/mm^3 (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Serum creatinine must be =< 1.5 X ULN (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Total bilirubin must be < 2 X ULN (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: AST (SGOT)/ALT (SGPT) =< 2.5 X institutional upper limit of normal (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Albumin >= 3.0 g/dL (within 2 weeks prior to registration)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients known to be human immunodeficiency virus (HIV)+ are permitted; patients with CD4 > 200 and serum HIV viral load of < 200 copies/mm^3 are eligible; in addition:
- Participants must be PPD negative; alternatively, the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay (Cellestis Limited, Carnegie, Australia) can be used; an individual is considered positive for M. tuberculosis infection if the IFN-gamma response to TB antigens is above the test cut-off (after subtracting the background IFN-gamma response in the negative control); the result must be obtained within 20 weeks prior to enrollment; PPD positive (or Quantiferon assay positive) participants are permitted if prophylaxis has been completed prior to enrollment; NOTE: If patient completed chemoradiation on Step 1, PPD testing does not need to be performed again
- No history of AIDS-related complications within past year other than a history of low CD4+ T-cell count > 200/mm^3 prior to initiation of combination antiretroviral therapy; on study CD4+ T-cell count may not be informative due to chemoradiotherapy should not be used as an exclusion criterion if low
- Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the anal cancer
- Participants MUST receive appropriate care and treatment for HIV infection, including antiretroviral medications when clinically indicated, and should be under the care of a physician experienced in HIV management; participants will be eligible regardless of antiretroviral medication (including no antiretroviral medication) provided there is no intention to initiate therapy or the regimen has been stable for at least 4 weeks with no intention to change the regimen within 12 weeks following enrollment
- Patient must have =< grade 2 diarrhea (participants with grade 1 diarrhea are eligible provided stool for ova/parasites and stool cryptosporidium studies are negative)
- NOTE: HIV testing is not required for eligibility
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Scans done within 4 weeks of randomization to Step 2
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient must have recovered from all toxicities associated with chemoradiotherapy for anal cancer, to grade =< 1 with the exception of alopecia
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Women of child bearing potential and sexually active males must use accepted and effective method(s) of contraception and/or abstain from sexual intercourse while on protocol treatment and for at least 5 months after the last dose of nivolumab (for female patients) and for at least 7 months after the last dose of nivolumab (for male patients)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No prior treatment with an immune checkpoint inhibitor (anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA4 monoclonal antibody)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No patients with immunodeficiency or receiving systemic steroid therapy equivalent to > 10 mg prednisone per day or any other form of immunosuppressive therapy within 7 days prior to the first dose of study medication; topical corticosteroid or occasional inhaled corticosteroids are allowed
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: No live vaccines within 30 days prior to the first dose of trial treatment and while participating in the trial; examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, BCG, and typhoid (oral) vaccine; seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines and are not allowed
Exclusion Criteria:
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: For patients registering to Arm T, patients must not have received prior chemoradiotherapy for anal cancer
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients with an allogenic bone marrow/stem, cell or solid organ transplant are excluded
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Women MUST NOT be pregnant or breast-feeding due to the potential teratogenic harm or abortifacient effects to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used; all patients must also not expect to conceive or father children from study registration and throughout their time on study treatment; for female patients this must continue until at least 5 months after the last dose of nivolumab and for male patients until at least 7 months after the last dose of nivolumab; all females of child bearing potential must have a serum or urine pregnancy test to rule out pregnancy within 2 weeks prior to registration; a female of childbearing potential is any woman, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients will be excluded if they have a T1 or M1, and T2N0 cancer
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must not have had prior potentially curative surgery (abdominal, peritoneal resection) for carcinoma of the anus
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Participants may not be receiving any other standard anti-cancer therapy or experimental agent concurrently with the study drugs
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Individuals with a history of a different malignancy are ineligible except if they have been disease-free for at least 2 years and are deemed by the investigator to be at low risk for recurrence; individuals with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, and basal cell or squamous cell carcinoma of the skin
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patient must not have active autoimmune disease in the past 2 years
- NOTE: This does not include patients with autoimmune disease controlled by medication, such as hypothyroidism; this eligibility includes only patients with endocrine disease controlled by hormone replacement, e.g. hypothyroid, adrenal insufficiency, or diabetes mellitus (DM)
-
REGISTRATION TO STEP 1 ELIGIBILITY CRITERIA: Patients must not have known interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients with an allogenic bone marrow/stem, cell or solid organ transplant are excluded
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Women MUST NOT be pregnant or breast-feeding due to the potential teratogenic harm or abortifacient effects to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used; all patients must also not expect to conceive or father children from study registration and throughout their time on study treatment; for female patients this must continue until at least 5 months after the last dose of nivolumab and for male patients until at least 7 months after the last dose of nivolumab; all females of child bearing potential must have a serum or urine pregnancy test to rule out pregnancy within 2 weeks prior to registration; a female of childbearing potential is any woman, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must not have had prior potentially curative surgery (abdominal, peritoneal resection) for carcinoma of the anus
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Participants may not be receiving any other standard anti-cancer therapy or experimental agent concurrently with the study drugs
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Individuals with a history of a different malignancy are ineligible except if they have been disease-free for at least 2 years and are deemed by the investigator to be at low risk for recurrence; individuals with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, and basal cell or squamous cell carcinoma of the skin
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patient must not have active autoimmune disease that has required systemic treatment in past 2 years
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must not have known interstitial lung disease that is symptomatic or may interfere with the detection or management of suspected drug-related pulmonary toxicity
-
REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to nivolumab
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
手臂数量
2
武器和干预
参与者组/臂参与者组/臂 |
干预/治疗干预/治疗 |
|---|---|
|
实验性的：Arm A (nivolumab)
Patients receive nivolumab while on study. Patients undergo sigmoidoscopy, colonoscopy or anoscopy, proctoscopy or digital rectal exam, x-ray, CT scan, MRI, biopsy and blood sample collection throughout the study. |
Undergo blood sample collection
其他名称：
Undergo MRI
其他名称：
Undergo chest x-ray
其他名称：
Undergo biopsy
其他名称：
Given IV
其他名称：
Undergo CT scan
其他名称：
Undergo colonoscopy Undergo digital rectal examination
其他名称：
Undergo anoscopy
其他名称：
Undergo proctoscopy Undergo sigmoidoscopy
其他名称：
|
|
其他：Arm B (clinical observation)
Patients undergo observation while on study. Patients undergo sigmoidoscopy, colonoscopy or anoscopy, proctoscopy or digital rectal exam, x-ray, CT scan, MRI, biopsy and blood sample collection throughout the study. |
Undergo blood sample collection
其他名称：
Undergo MRI
其他名称：
Undergo chest x-ray
其他名称：
Undergo CT scan
其他名称：
Undergo colonoscopy Undergo digital rectal examination
其他名称：
Undergo anoscopy
其他名称：
Undergo proctoscopy Undergo sigmoidoscopy
其他名称：
Undergo observation
其他名称：
|
研究衡量的是什么？
主要结果指标
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Disease free survival
大体时间：Up to 7 years
|
Will be defined as the occurrence of progression of local disease, distant metastases, second primary or death from the date of randomization. |
Up to 7 years
|
次要结果测量
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
总生存期
大体时间：长达 7 年
|
长达 7 年
|
|
|
Objective response rate
大体时间：Up to 7 years
|
Will be defined by complete and partial response. |
Up to 7 years
|
|
Severe toxicity interval
大体时间：The time between randomization and the occurrence of late severe side effects (up to 7 years)
|
The following late side effects are considered as severe: any anal/rectal damage (ulcer, fistula, or perforation), rectal stenosis that required colostomy, skin ulceration, and severe fibrosis. This parameter estimates the probability of being free of late side effects for patients under loco-regional control. |
The time between randomization and the occurrence of late severe side effects (up to 7 years)
|
|
Colostomy-free survival
大体时间：Up to 7 years
|
Up to 7 years
|
|
|
Incidence of toxicities
大体时间：Up to 7 years
|
Will be assessed by National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0. |
Up to 7 years
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
调查人员
- 首席研究员：Lakshmi Rajdev、ECOG-ACRIN Cancer Research Group
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
学习开始
2018年7月5日
初级完成 (估计的)
初级完成
2027年12月31日
研究完成 (估计的)
研究完成
2027年12月31日
研究注册日期
首次提交
首次提交
2017年7月28日
首先提交符合 QC 标准的
首先提交符合 QC 标准的
2017年7月28日
首次发布 (实际的)
首次发布
2017年7月31日
研究记录更新
最后更新发布 (实际的)
最后更新发布
2026年11月2日
上次提交的符合 QC 标准的更新
上次提交的符合 QC 标准的更新
2026年10月30日
最后验证
最后验证
2026年10月1日
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
- 按部位分类的肿瘤
- 肿瘤
- 肠道疾病
- 消化道肿瘤
- 消化系统肿瘤
- 消化系统疾病
- 肠胃疾病
- 结直肠肿瘤
- 肠道肿瘤
- 直肠疾病
- 肛门疾病
- 直肠肿瘤
- 肛门肿瘤
- 肛管癌
- 卫生服务管理局
- 氨基酸，肽和蛋白质
- 蛋白质
- 调查技术
- 方法
- 临床实验室技术
- 诊断技术和程序
- 诊断
- 手术程序，手术
- 微创手术程序
- 细胞学技术
- 细胞诊断
- 医疗保健质量
- 身体现象
- 设备和用品
- 抗体，单克隆，人源化
- 抗体，单克隆
- 抗体
- 免疫球蛋白
- 免疫蛋白
- 血蛋白
- 血清球蛋白
- 球蛋白
- 诊断技术，手术
- 内窥镜检查，胃肠道
- 内窥镜检查，消化系统
- 诊断技术，消化系统
- 内窥镜检查
- 消化系统手术程序
- 化学技术，分析
- 频谱分析
- 电磁现象
- 磁现象
- 结果评估，医疗保健
- 结果和过程评估，医疗保健
- 电磁辐射
- 辐射
- 辐射，电离
- 纳武单抗
- 观察
- 活检
- 标本处理
- 结肠镜检查
- 磁共振光谱
- 注意等待
- X射线
- 幻影，成像
- 前镜镜检查
- 乙状结肠镜检查
其他研究编号
其他研究编号
- NCI-2017-01347
- U10CA180820 (美国 NIH 拨款/合同)
- NCI-2017-01347 (注册表标识符：CTRP (Clinical Trial Reporting Program))
- EA2165 (其他标识符：CTEP)
- EA2165 (其他标识符：ECOG-ACRIN Cancer Research Group)
药物和器械信息、研究文件
研究美国 FDA 监管的药品
是的
研究美国 FDA 监管的设备产品
不
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