Gene Expression Profiling in Type 1 Diabetes
One of the goals of the Kansas City Diabetes Consortium is to identify and characterize genes and their products that are associated with T1DM. Characterization of such genes and their products can aid in developing new tools for risk assessment, development of new prevention strategies and monitoring progression of disease.
Study design: Descriptive, basic science pilot study. The results of this pilot study will be used to help design a much larger study to address the importance of viral response and autoimmune diabetes.
研究概览
地位
条件
详细说明
The hypothesis is that viral responsive genes are up-regulated prior to the onset of symptoms of Type 1 Diabetes (T1DM) and may correlate with increased expression of interferon alpha.
Both genetic and environmental factors contribute to risk of development of T1DM. There are a number of conflicting reports associating viral infections and T1DM in genetically susceptible individuals and causality has not been proven. Viruses may not have a large role in the initiation of islet cell autoimmunity but more of a role in acceleration of the disease leading to overt symptoms. There are no studies describing viral responsive gene expression in these individuals.
研究类型
注册 (预期的)
联系人和位置
学习地点
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Missouri
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Kansas City、Missouri、美国、64108
- Children's Mercy Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
Male and female subjects 7-14 years of age
- New onset T1DM
- Five years post onset of T1DM
描述
Inclusion Criteria:
- Male and female subjects 7-14 years of age
- New onset T1DM
- Five years post onset of T1DM
- Participant in the TrialNet initiative and either antibody positive or antibody negative sibling control
- Body weight sufficient to tolerate an additional 15ml (1 tbsp) blood loss
Exclusion Criteria:
- Subjects who do not meet the criteria above
- Subjects who have received steroids or other immunosuppressive therapy within the 6 months prior to enrollment into the study
学习计划
研究是如何设计的？
设计细节
合作者和调查者
调查人员
- 首席研究员：Karen Kover, PhD、Children's Mercy Hospital Kansas City
研究记录日期
研究主要日期
学习开始
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.