Inspiratory Flow and Volumes in Bronchiectatics
Inspiratory Flow Rates and Volumes in Subjects With Bronchiectasis Using Low and High Resistance Dry Powder Inhaler Devices
Adequate administration of drugs via dry powder inhalers is dependent on adequate inspiratory flow rates and volumes. These vary according to the device being used and its resistance. The dry powder inhaler device under investigation is a device approved by the Therapeutic Goods Administration (ARTG no. 196255) for use with dry powder mannitol. Dry powder mannitol is currently being investigated as a treatment for bronchiectasis. We wish to measure the inspiratory flow characteristics of both the low and high resistance devices amongst a group of subjects with bronchiectasis.
We propose that the majority of subjects investigated with varying lung function will achieve adequate flow during a controlled inspiration.
研究概览
地位
条件
研究类型
注册 (预期的)
联系人和位置
学习地点
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New South Wales
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Camperdown、New South Wales、澳大利亚、2050
- Royal Prince Alfred Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- non-cf bronchiectasis
- aged 18-80 inclusive
- FEV1 greater or equal to 50% predicted and greater or equal to 1L
Exclusion Criteria:
- uncontrolled asthma
- CF bronchiectasis
- have any condition for which spirometry measurement would be contraindicated
学习计划
研究是如何设计的？
队列和干预
团体/队列 |
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1
subjects with bronchiectasis
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
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inspiratory flow
大体时间：single visit
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single visit
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次要结果测量
结果测量 |
大体时间 |
|---|---|
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inspiratory volume
大体时间：single visit
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single visit
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合作者和调查者
赞助
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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