Analysis of Oculo-motor Deficiencies Associated With FMR1 Gene Expression (Genetic Abnormality Predisposing to a Neurodegenerative Disease)

FOR PATIENTS WITH PREMUTATION ON FMR1 GENE (30 patients expected):

Inclusion criteria:

• Male
• > or equal to 50 years old
• Ally second or third degree with a child affected of "fragile X"
• Not living far from Nantes so that visits to the Nantes hospital can be easy
• Pre-mutation on FMR1 gene
• Signed informed consent

Exclusion criteria:

• Female
• <50 years old
• visual acuteness < 1/10
• MATTIS dementia scale <100 (normal:144)
• Occurrence, shown by MRI (Magnetic Resonance Imaging), of a pathology either ischemic vascular or hemorrhagic or tumoral

FOR PATIENTS WITHOUT PRE-MUTATION ON FMR1 GENE (10 patients expected):

Inclusion criteria:

• Male
• > or equal to 50 years old
• Ally second or third degree with a child affected of "fragile X"
• Not living far from Nantes so that visits to the Nantes hospital can be easy - Signed informed consent

Exclusion criteria:

• Female
• <50 years old
• visual acuteness < 1/10
• MATTIS dementia scale <100 (normal:144)
• Pre-mutation on FMR1 gene
• Occurrence, shown by MRI, of a pathology either ischemic vascular or hemorrhagic or tumoral

FOR PATIENTS WITH MULTI-SYSTEMATIZED ATROPHY (10 patients expected):

Inclusion criteria:

• Male
• > or equal to 50 years old
• Not living far from Nantes so that visits to the Nantes hospital can be easy
• "probable" diagnosis of multi-systematized atrophy
• Signed informed consent

Exclusion Criteria:

• Female
• <50 years old
• visual acuteness < 1/10
• MATTIS dementia scale <100 (normal:144)
• Occurrence, shown by MRI, of a pathology either ischemic vascular or hemorrhagic or tumoral