Serum, Plasma, DNA and Tissue Bank in Chronic Obstructive Pulmonary Disease and Lung Cancer
Serum, Plasma, DNA and Tissue Bank of Patients With Chronic Obstructive Pulmonary Disease, Lung Cancer and Smoking Controls.
A biobank of Serum, plasma, DNA samples together with clinical information including specific questionnaires, complete pulmonary function and chest CT-scan, is prospectively collected in patients seen at the investigators' clinical service.
The objective is to study candidate gene pathways in COPD and or lung cancer and to associate them with the clinical characteristics and phenotypes of COPD/emphysema and lung cancer.
In subgroups of well characterised patients, other biological materials are also collected (lung tissue biopsies, peripheral blood mononuclear cells).
研究概览
详细说明
All patients with a smoking history of at least 15 pack years, an minimal age of 50 years and an recent available CT scan are enrolled.
All subjects with a diagnosis of lung cancer are also collected (irrespective of age and smoking behavior).
In addition the investigators collect:
- specific questionnaires (MRC, CCQ and smoking history)
- medical and professional history
- complete pulmonary function (spirometry, bodyplethysmography and diffusing capacity)
- serum, plasma and DNA samples.
In specific subgroups the investigators also collect:
- Peripheral blood mononuclear cells
- Lung tissue - if available - from a surgical procedure (lung transplantation or lobectomy)
研究类型
注册 (预期的)
联系人和位置
学习地点
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Flanders
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Leuven、Flanders、比利时、3000
- 招聘中
- Katholieke Universiteit Leuven
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接触：
- Wim Janssens, Prof
- 电话号码：032 (16) 34 68 00
- 邮箱：wim.janssens@uz.kuleuven.ac.be
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副研究员：
- Marc Decramer, MD. PhD.
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副研究员：
- Diether Lambrechts, PhD
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副研究员：
- Paul Deleyn, MD PhD
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria for smokers:
- A smoking history of at least 15 pack years and age of 50 years or older
- Complete pulmonary function on day of visit
- Chest CT-scan within one year of enrollment
- 4 weeks from exacerbation
Exclusion Criteria for smokers:
- Less than 15 pack years
- Younger than 50 year
- Other pulmonary diseases interfering with CT or pulmonary function
- Asthma
Inclusion Criteria for lung cancer patients:
- new diagnosis of proven lung cancer
- chest CT scan within 2 months of enrollment
- Complete pulmonary function
Exclusion Criteria for lung cancer patients
- not able to perform pulmonary function
- Absence of histological diagnosis of lung cancer
学习计划
研究是如何设计的？
设计细节
- 观测模型：病例对照
- 时间观点：预期
队列和干预
团体/队列 |
|---|
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Smoking controls
Smokers without lung cancer and without COPD
|
|
COPD patients
Smokers with COPD but without lung cancer
|
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Lung cancer patients
smokers - never smokers with lung cancer
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Serological, cytological, histological and genetic analysis of biomarkers or genes which are involved in the pathogenesis of COPD/Emphysema/Lungcancer.
大体时间：0-1-3-6 years
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All cases are prospectively collected in University hospital Leuven, Belgium.
Of enrolled subjects data are collected at 0,1,3 and 6 years interval
|
0-1-3-6 years
|
合作者和调查者
赞助
调查人员
- 首席研究员：Wim Janssens, MD. PhD.、KU Leuven
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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