The Metabolic Effects of a High Fructose Versus a High Glucose Diet in Overweight Men
Dietary consumption of fructose has increased by nearly 50% since 1960.
A high fructose diet (HFrD) results in greater visceral adiposity and systemic insulin resistance than a high glucose diet. The effects of fructose on liver fatty acid and ATP stores, systemic oxidative stress and cardiovascular status are not fully known.
研究概览
地位
干预/治疗
详细说明
The protocol will assess the following outcomes:
- The ultimate fate of this increased hepatic fatty acid production following a high fructose vs. glucose diet
- The effect of a high fructose vs. glucose diet on liver ATP stores
- The effect of a high fructose vs. glucose diet on markers of oxidative stress
- The effect of a high fructose vs. glucose diet on cardiovascular status
Factors critical to carbohydrate metabolism such as systemic insulin resistance, body composition, energy expenditure, physical activity will also be assessed.
32 centrally overweight healthy males with a low baseline fructose intake will be recruited. They will be randomised double blindly to receive 25% of their dietary energy requirements from either fructose or glucose for 14 days.
The sugars will first be taken in an energy balanced and then an overfeeding setting.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
-
-
Nottinghamshire
-
Nottingham、Nottinghamshire、英国、NG7 2UH
- School of Biomedical Sciences, University of Nottingham
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Body mass index 25-32
- Waist > hip circumference
- Age 18-50 years
- Male
Exclusion Criteria:
- Reported weight change > 3 kg in prior 3/12
- Active health problems
- Contraindications to MRI scanning
- Symptoms of functional bloating or irritable bowel syndrome
- Abnormal liver or renal function tests
- Random glucose greater than 11.0 mmol/L
- Evidence of metabolic or viral liver disease as screened for by hepatitis B and C serology, and ferritin.
- Alcohol intake > 21 units per week
- Vegetarianism
- Normal daily fructose intake from drinks greater than that in 500ml of coca cola
- Abnormal carbohydrate energy contribution to baseline diet - defined as greater than 2 standard deviations from the mean of the National Diet and Nutrition Survey 2002 data
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：四人间
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：fructose
25% dietary energy from fructose
|
25% of dietary energy from fructose or glucose
|
|
有源比较器：glucose
25% dietary energy from glucose
|
25% of dietary energy from fructose or glucose
|
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
Liver triglyceride content
大体时间：2 weeks
|
2 weeks
|
次要结果测量
结果测量 |
大体时间 |
|---|---|
|
Muscle triglyceride content
大体时间：2 weeks
|
2 weeks
|
|
Total abdominal visceral fat content (MRI)
大体时间：2 weeks
|
2 weeks
|
|
Liver ATP, PME concentration and pH (31P MRS)
大体时间：2 weeks
|
2 weeks
|
|
Liver de novo lipogenesis
大体时间：2 weeks
|
2 weeks
|
|
Resting energy expenditure, lipid and carbohydrate oxidation rates
大体时间：2 weeks
|
2 weeks
|
|
Hepatic and systemic insulin resistance
大体时间：2 weeks
|
2 weeks
|
|
Cardiovascular measures using finometry
大体时间：2 weeks
|
2 weeks
|
|
Systemic oxidative stress and inflammatory cytokine profile
大体时间：2 weeks
|
2 weeks
|
合作者和调查者
调查人员
- 学习椅：Ian A Macdonald, PhD、School of Biomedical Sciences, Nottingham University, UK
- 首席研究员：Richard D Johnston, MRCP、School of Biomedical Sciences, Nottingham University, UK
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.