Study on Mechanical and Electrical Alternans
The Connection Between Mechanical Alternans Measured by Pressure-Volume (PV) Loop Catheter in Patients With Ischemic Heart Failure and the Occurrence of Microvolt T Wave Alternans (MTWA)
研究概览
详细说明
In patients with severe heart failure and aortic valve disease mechanical alternans or pulsus alternans (a condition in which there is a beat-to-beat oscillation in the strength of cardiac muscle at a constant heart rate) is observed.
The mechanisms linking mechanical to electrophysiological dysfunction in heart failure are still under investigation, but impaired calcium cycling is the most striking abnormality of failing myocytes, and is most responsible for contractile dysfunction. Yet it remains unclear how this influences susceptibility to arrhythmias.
The MTWA is suggested as a risk marker to identify high risk patients for potential VTEs but the underlying mechanism is not completely understood. The aim of this study is to investigate this in a clinical setting by measuring LV parameters using a PV loop conductance catheter and generate TWA recording simultaneously to demonstrate a possible correlation between these two phenomena in patients with ischemic heart failure and find out if MTWA could turn into a more valuable risk factor.
Our hypothesis is that alternating changes in LV filling explains the electrocardiogenesis of TWA by changing the position of the heart relative to the body surface electrodes in an alternating way.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Amsterdam、荷兰
- Academic Medical Center
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Patients with heart failure caused by coronary artery disease
- Indication for left ventricular radiofrequency (LV RF) ablation
- LVEF ≤ 35% measured by echocardiogram or MRI
Exclusion Criteria:
- hemodynamically instable patients
- age under 18 and over 85 years,
- heart failure not caused by coronary artery disease
- Severe co-morbidity
学习计划
研究是如何设计的?
设计细节
研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
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Presence or absence of mechanical alternans and MTWA
大体时间:1 year
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1 year
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次要结果测量
结果测量 |
大体时间 |
---|---|
Differences in reduced or more preserved LVEF and the occurrence of the two phenomena
大体时间:1 year
|
1 year
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The occurrence of ventricular tachyarrhythmic events.
大体时间:1 year
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1 year
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Influence of LV compliance on arrhythmogenesis of the infarction border zone.
大体时间:1 year
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1 year
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合作者和调查者
调查人员
- 首席研究员:Arthur AM Wilde, MD, PhD、Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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