Effects of Pancreaticoduodenectomy on Glucose Metabolism
研究概览
详细说明
Questionaire All studied patients will be requested to self-complete a detailed questionnaire that collects information on demographic data, including usual adult height and weight, and history of DM in first-degree relatives. Existing medical conditions, including DM, duration of these medical problems, and current medications will also be inquired. The database will also include details of weight measured at the time of recruitment and body mass index (BMI), calculated as weight (kg)/height2 (m2). All studied patients will have FBG levels measured. Patients receiving prescription antidiabetic medications for previously diagnosed DM will be classified as having DM regardless of their FBG value. Among patients not reporting treatment for DM, classification of DM status will be based on the American Diabetes Association criteria; patients will be classified as having DM if the FBG level is ≧126 mg/dL (7 mmol/L), as having impaired fasting glucose (IFG) if their FBG is between 100 and 125 mg/dL (5.6-6.9 mmol/L), and as having normal fasting glucose (NFG) if their FBG value is ≦99 mg/dL (5.5 mmol/L).
After withdrawal of anti-diabetic medications for 12 h, the patients were asked to fast overnight for 12 h, then were given 200 ml of formula (220kcal, 14g of protein, 28 g of carbohydrates, and 5 g of fat; Modifast, Stocksund, Sweden) within 10 min through a NG tube on post-operative day 5 (proximal feeding group [PFG]) and a jejunostomy feeding tube (distal feeding group [DFG]) on post-operative day 6. The below parameter will be checked, including
- HOMA insulin resistance assessment (HOMA-IR)
- GLP-1
- GIP
- C-peptide
- Insulin
- Glucose
研究类型
注册 (预期的)
联系人和位置
学习地点
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Taipei、台湾、100
- 招聘中
- National Taiwan University Hospital
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接触:
- Yu-Wen Tien, Ph.D.
- 电话号码:+886-972651427
- 邮箱:kptkptkpt@yahoo.com.tw
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首席研究员:
- Yu-Wen Tien, Ph.D.
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Patients receiving pancreaticoduodenectomy
Exclusion Criteria:
- history of pancreatitis
- hepatic dysfunction (Child-Pugh > 2)
- renal dysfunction (serum creatinine concentration > 3 mg/L, hemodialysis, or both)
- pregnancy
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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Receiving pancreaticoduodenectomy
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Change of glucose metabolism after pancreaticoduodenectomy
大体时间:on the post-operative day 5 and day 6
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Measurement of glucose, glucagon-like peptide-1, Measurement of insulin, C-peptide, and glucagon concentrations after meal test
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on the post-operative day 5 and day 6
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合作者和调查者
调查人员
- 学习椅:Yu-Wen Tien, M.D., Ph.D.、National Taiwan University Hospital
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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