Prospective Analysis Of Cardiac Function In Cirrhotic Patients By Echocardiography And Its Correlation With Events
Prospective Analysis Of Cardiac Function In Cirrhotic Patients By Echocardiography And Its Correlation With Adverse Events
The cardiac abnormalities in patients with cirrhosis are already reported from the 50's, in studies of patients with alcoholic cirrhosis. Further studies have shown that these cardiac changes were caused not only by the myotoxic effects of alcohol, but also are present in many patients regardless of etiology of cirrhosis.
These changes are characterized by abnormalities of systolic contraction in patients undergoing physical or pharmacological stress, changes in diastolic function and electrophysiological changes in a clinical condition known as cirrhotic cardiomyopathy. Increased QT interval and the pre-ejection time changes are common in cirrhotic patients.
To date no studies have evaluated the clinical relevance of changes in the heart of cirrhotic patients, or their relationship with the prognosis of affected patients. Til now, researches are based on strict echocardiographic parameters, not including several modern methods of assessment of cardiac systole and diastole. New techniques, such as two-dimensional strain, can bring new diagnostic and prognostic information, and it is not reported in the literature. Therefore, the aim of this study is to determine the morphological and functional cardiac changes in patients with cirrhosis and their prognostic role by evaluating new echocardiographic parameters of systolic and diastolic readings.
研究概览
地位
条件
研究类型
注册 (预期的)
联系人和位置
学习地点
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RJ
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Rio de Janeiro、RJ、巴西、20551030
- Universidade do Estado do Rio de Janeiro
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Patients with cirrhosis of any etiology, diagnosed by clinical criteria and ultrasound and / or liver biopsy, which excluded patients with causes that also may affect cardiac function (hemochromatosis, Wilson disease, amyloidosis).
- Age between 18 and 80 years.
- Signing of written informed consent.
Exclusion Criteria:
- History or presence of systemic arterial hypertension (treated or not)
- History or presence of ischemic heart disease and peripheral vascular disease.
- Presence of greater than mild valvular disease.
- Patients who have a different rhythm in the baseline electrocardiogram, other than sinus (atrial fibrillation, atrial flutter, junctional rhythm).
- Presence of severe anemia (Hb <7 g / dL).
- Presence of shock, hepatic encephalopathy, bacterial infection or bleeding at inclusion or during the previous week.
- History or presence of severe or decompensated lung disease.
- Presence of percutaneous intrahepatic porto-systemic shunt (TIPS).
- Pregnancy.
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
|---|
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Child A liver cirrhosis
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Child B liver cirrhosis
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Child C liver cirrhosis
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Adverse events as defined as composite of death due to liver failure, gastrointestinal bleeding, spontaneous bacterial peritonitis or need to conduct liver transplant in patients with liver cirrhosis.
大体时间：12 months follow-up
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Identify the occurrence of adverse events as defined as:
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12 months follow-up
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合作者和调查者
调查人员
- 首席研究员：Angelo A Salgado, Master、Rio de Janeiro State University
- 学习椅：Carlos Terra, PHD、Rio de Janeiro State University
- 学习椅：Márcia B Castier, PHD、Rio de Janeiro State University
- 学习椅：Paulo R Benchimol-Barbosa, DSC、Rio de Janeiro State University
- 首席研究员：Camila SS Reis, MD、Universidade de Estado do Rio de Janeiro
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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