Long-term Outcome Related Prognostic Factor and Biomarkers of Major Trauma Database Analysis
研究概览
地位
条件
详细说明
Severe traumatic injury occupied the sixth leading cause of death in Taiwan, especially in young adults. In 2013, there were accidental deaths in every 76 minutes. Not compared with the malignancy, heart disease, cerebrovascular disease, diabetes mellitus, or pneumonia Since 1995, Taiwan replaced a previous patchwork of separate social health insurance funds with one single-payer, National Health Insurance (NHI) scheme that is administered by an agency of the central government's Department of Health. NHI supported the cost of Critical Illness and Injury that numerous patients with major trauma were eligible for preference. However, the national medical cost of trauma care, especially in poly-trauma or major trauma were impressive: the adjusted national inpatient trauma yearly costs were estimated at $37,511,328,659 US dollars; the national insurance cost provided by Bureau of National Health Insurance, Department of Health for trauma was over $20,000,000,000 new Taiwan dollars till 1999 with increasing yearly.
Recently it flashed bulletins nationwide and overseas for catastrophes, such as aircraft accident, wrecks, or underground gas explosions. There was a stirring of interest in life support system for major trauma related rescue from dying. Death to trauma is caused by costly damages on scene, hemorrhage shock or trauma and massive transfusion related acute respiratory distress syndrome (ARDS). Extra-Corporeal Membrane Oxygenation (ECMO) can rescue life from severe cardiopulmonary failure, but coexisting complication as bleeding and coagulopathy restricting the utilization the use in trauma patients. Besides, there were more portable ECMO sets making a debut, especially for air transportation. It act now the medical transferral for trauma patients under ECMO support. The portable ECMO sets launched with possibility, accessibility, and convenience. The issue of life support system utilization, long-term outcome, and medical cost-effectiveness for major trauma patients was worth discussing no matter in National Taiwan University Hospital (NTUH) trauma database or National Health Insurance Research Database (NHIRD).
Immune system alteration was previously considered the mechanism of post-traumatic stress disorder (PTSD). Moreover, an externally experienced traumatic event induces downstream alterations in immune function by reducing methylation.
研究类型
注册 (预期的)
联系人和位置
学习地点
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Taipei City、台湾、100
- 招聘中
- National Taiwan University Hospital
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接触:
- Ting-Chun Kuo
- 电话号码:886-97265-3245
- 邮箱:tina@ntuh.gov.tw
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion criteria:
- age ≧ 20
- willing to join this study and sign the inform consent form by the patients or their contactable families
- ISS score ≧ 16, or meet trauma blue or trauma red criteria
- response to primary resuscitation
- without uncontrolled or major (>1500mL) bleeding.
Exclusion criteria:
- active malignancy before the event of major trauma
- age <20, pregnancy woman, breast-feeding woman, or mental illness
- uncontrolled bleeding with hemoglobin <7g/dL after treatment.
学习计划
研究是如何设计的?
设计细节
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Event related survival
大体时间:30 days
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since major trauma event till trauma related death
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30 days
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Functional status
大体时间:12 months
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Besides Rehabilitation Complexity Scale (RCS) and Functional Independence Measure (FIM) for traumatic brain injury patients, Glasgow Outcome Scale - Extended (GOS-E) and European Quality of Life Five Dimensions Questionnaire (EQ-5D) are used in concerning longer-term outcome indicators.
There are currently no robust measures of patient experience for use in major trauma.
Functional status after the major trauma event could be measured using non-clinical outcomes such as return to work, maintenance of education and societal dependency at post injury 3, 6, and 12 months.
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12 months
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over all survival
大体时间:2 years
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since major trauma event till death
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2 years
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合作者和调查者
调查人员
- 首席研究员:Ting-Chun Kuo, M.D.、No.7, Chung San South Road, Taipei City 100, Taiwan (R.O.C.)
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
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