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Clinical and Genetic Characteristics of Coronary Artery Disease in Chinese Young Adults (GRAND)

2019年2月20日更新者：Junbo Ge、Shanghai Zhongshan Hospital

The aim of this study is to identify genetic loci,or gene variations contributing to the development of coronary artery disease (CAD) in Chinese young adults. Investigators will compare coronary angiogram results to genetic findings within young CAD patients.

研究概览

地位

未知

条件

详细说明

During last 10 years, the rise in coronary artery disease (CAD) prevalence in Chinese young adults is observed and percutaneous coronary intervention (PCI) is generally considered to be low operative risk in these young patients. Genome-wide association studies have identified a considerable number of common genetic variants related to CAD. However, the extent to which these genetic variants are related to the future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with CAD is not clear.

The aim of this study is to investigate the genetic loci, or gene variations contributing to the development and prognosis of CAD in Chinese young adult. Investigators will compare the angiogram results to genetic findings first in patients with different stages of CAD. Then, investigators will collect patients from hospital discharge registry, and compare long-term outcome as well as on operative details in different gene groups.

The results of the study provide a possibility to develop a gene test to recognize patients at risk at its early stage, and needing for preventive medicine.

研究类型

观察性的

注册 (预期的)

2000

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

中国
- Beijing
  - Beijing、Beijing、中国
    - 招聘中
    - China-Japan Friendship Hospital
    - 接触：
      
      Jingang Zheng
- Fujian
  - Xiamen、Fujian、中国
    - 招聘中
    - Xiamen Cardiovascular Hospital
    - 接触：
      
      Yan Wang
- Gansu
  - Lanzhou、Gansu、中国
    - 招聘中
    - The First Hospital of Lanzhou University
    - 接触：
      
      Zheng Zhang
- Guangdong
  - Guangzhou、Guangdong、中国
    - 招聘中
    - Guangdong Provincial People's Hospital
    - 接触：
      
      Yingling Zhou
  - Guangzhou、Guangdong、中国
    - 招聘中
    - Sun Yat-sen Memorial Hospital
    - 接触：
      
      Jingfeng Wang
  - Zhuhai、Guangdong、中国
    - 招聘中
    - Zhuhai Hospital of Guangdong Provincial People's Hospital
    - 接触：
      
      Yingling Zhou
- Guangxi
  - Nanning、Guangxi、中国
    - 招聘中
    - The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine
    - 接触：
      
      Guixin He
- Guizhou
  - Zunyi、Guizhou、中国
    - 招聘中
    - Affiliated Hospital of Zunyi Medical College
    - 接触：
      
      Bei Shi
- Hebei
  - Shijiazhuang、Hebei、中国
    - 招聘中
    - The Second Hospital of Hebei Medical University
    - 接触：
      
      Yongjun Li
- Hubei
  - Wuhan、Hubei、中国
    - 招聘中
    - Wuhan Asia Heart Hospital
    - 接触：
      
      Xi Su
- Jiangsu
  - Wuxi、Jiangsu、中国
    - 招聘中
    - Wuxi Third People's Hospital
    - 接触：
      
      Xiaoyan Wang
  - Xuzhou、Jiangsu、中国
    - 招聘中
    - Xuzhou Fourth People's Hospital
    - 接触：
      
      Yijie Huang
- Jiangxi
  - Nanchang、Jiangxi、中国
    - 招聘中
    - The First Affiliated Hospital of Nanchang University
    - 接触：
      
      Zeqi Zheng
- Jilin
  - Chang chun、Jilin、中国
    - 招聘中
    - The Second Hospital of Jilin University
    - 接触：
      
      Bin Liu
- Ningxia
  - Yinchuan、Ningxia、中国
    - 招聘中
    - General Hospital of Ningxia Medical University
    - 接触：
      
      Shaobin Jia
- Shaanxi
  - Xi'an、Shaanxi、中国
    - 招聘中
    - The First Affiliated Hospital of Xi 'an Jiaotong University
    - 接触：
      
      Yanni Wang
- Shanghai
  - Shanghai、Shanghai、中国、200032
    - 招聘中
    - Shanghai Zhongshan Hospital
    - 首席研究员：
      
      Junbo Ge, Professor
    - 接触：
      
      Kang Yao
      
      电话号码：86-13818988550
    - 接触：
      
      Yuxiang Dai
  - Shanghai、Shanghai、中国
    - 招聘中
    - Shanghai Chest Hospital
    - 接触：
      
      Ben He
  - Shanghai、Shanghai、中国
    - 招聘中
    - Shanghai Sixth People's Hospital
    - 接触：
      
      Chengxing Shen
  - Shanghai、Shanghai、中国
    - 招聘中
    - Shanghai Changzheng Hospital
  - Shanghai、Shanghai、中国
    - 招聘中
    - Tenth People's Hospital of Tongji University
    - 接触：
      
      Yawei Xu
  - Shanghai、Shanghai、中国
    - 招聘中
    - Tongji Hospital of Tongji University
    - 接触：
      
      Xuebo Liu
  - Shanghai、Shanghai、中国
    - 招聘中
    - Shanghai Tongren Hospital
    - 接触：
      
      Zening Shen
  - Shanghai、Shanghai、中国
    - 招聘中
    - Central Hospital of Jiading District
    - 接触：
      
      Xiangdong Xu
  - Shanghai、Shanghai、中国
    - 招聘中
    - Central Hospital of Minhang District
  - Shanghai、Shanghai、中国
    - 招聘中
    - Central Hospital of Yangpu District
    - 接触：
      
      Pengxiang Zheng
  - Shanghai、Shanghai、中国
    - 招聘中
    - Changhai Hospital of Second Military Medical University of Chinese PLA
    - 接触：
      
      Xianxian Zhao
  - Shanghai、Shanghai、中国
    - 招聘中
    - Shanghai First People's Hospital
    - 接触：
      
      Shaowen Liu
  - Shanghai、Shanghai、中国
    - 招聘中
    - Shanghai Ninth People's Hospital
  - Shanghai、Shanghai、中国
    - 招聘中
    - Shanghai Shidong Hospital
    - 接触：
      
      Liuliu Feng
  - Shanghai、Shanghai、中国
    - 招聘中
    - Yueyang Hospital
    - 接触：
      
      Min Fan
- Shanxi
  - Taiyuan、Shanxi、中国
    - 招聘中
    - Shanxi Cardiovascular Hospital
    - 接触：
      
      Xuebin Han
  - Taiyuan、Shanxi、中国
    - 招聘中
    - Taiyuan Central Hospital
    - 接触：
      
      Dengfeng Ma
- Tianjin
  - Tianjin、Tianjin、中国
    - 招聘中
    - Tianjin Chest Hospital
    - 接触：
      
      Yin Liu
- Xinjiang
  - Karamay、Xinjiang、中国
    - 招聘中
    - Karamay Central Hospital
    - 接触：
      
      Xiaohong Liu
- Yunnan
  - Kunming、Yunnan、中国
    - 主动，不招人
    - Yan'an Hospital of Kunming City
- Zhejiang
  - Hangzhou、Zhejiang、中国
    - 招聘中
    - Second Affiliated Hospital of Zhejiang University
- Zhenjiang
  - Hangzhou、Zhenjiang、中国
    - 招聘中
    - Zhenjiang First People's Hospital
    - 接触：
      
      Guohui Zhang

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年至 45年 (成人)

接受健康志愿者

是的

有资格学习的性别

全部

取样方法

概率样本

研究人群

Patients aged ≤45 years diagnosed with CAD by coronary angiography will be collected from multiple institutions.

描述

Inclusion criteria:

premature CAD, includes patients who aged ≥ 18 and ≤ 45 years , and with at least one main coronary artery stenosis ≥ 50% confirmed by coronary angiography, involving left main coronary artery, left anterior descending branch, left circumflex branch or right coronary artery, and manifested as occult CAD, stable CAD, unstable angina pectoris, non-ST segment elevated myocardial infarction and ST segment elevated myocardial infarction;
mature CAD, refers to patients who aged ≥ 65 years and meat the same CAD diagnostic criteria as above;
age matched individuals who had coronary arteries without obvious stenosis.

Exclusion criteria:

severely sick with limited life-expectancy < 1 year;
patients with malignancies;
pregnant or planning for pregnancy.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

团体/队列数

队列和干预

团体/队列
Early-onset CAD The anticipated 2000 young CAD patients who aged ≤45years undergoing coronary angiography will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.
Late-onset CAD The anticipated 2000 old CAD patients aged≥65years undergoing coronary angiography will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.
Age-matched controls The anticipated 2000 control subjects without obvious coronary stenosis aged≤45years or ≥65years will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
Number of cardiac death 大体时间：36 months	Any death from cardiac conditions	36 months
Number of patients developing myocardial infarction 大体时间：36 months	Any case of acute myocardial infarction which meet the Criteria according to current guidelines.	36 months
Number of patients developing stroke 大体时间：36 months	Any events of ishcemic stroke, TIA or hemorrhagic stroke	36 months
Number of participants undergoing unscheduled repeat revascularization of target or non-target vessel 大体时间：36 months	Any unshceduled percutaneous coronary intervention or coronary artery bypass grafting after primary revascularization	36 months

次要结果测量

结果测量	措施说明	大体时间
Number of stent thrombosis, bleeding、non-cardiac death and all-cause death. 大体时间：36 months	Composite of stent thrombosis, bleeding、non-cardiac death and all-cause death.	36 months

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Shanghai Zhongshan Hospital

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2017年5月12日

初级完成 (预期的)

2019年5月1日

研究完成 (预期的)

2022年5月1日

研究注册日期

首次提交

2015年7月7日

首先提交符合 QC 标准的

2015年7月9日

首次发布 (估计)

2015年7月14日

研究记录更新

最后更新发布 (实际的)

2019年2月21日

上次提交的符合 QC 标准的更新

2019年2月20日

最后验证

2019年2月1日