- ICH GCP
- Registro de ensaios clínicos dos EUA
- Ensaio Clínico NCT02496858
Clinical and Genetic Characteristics of Coronary Artery Disease in Chinese Young Adults (GRAND)
Visão geral do estudo
Status
Descrição detalhada
During last 10 years, the rise in coronary artery disease (CAD) prevalence in Chinese young adults is observed and percutaneous coronary intervention (PCI) is generally considered to be low operative risk in these young patients. Genome-wide association studies have identified a considerable number of common genetic variants related to CAD. However, the extent to which these genetic variants are related to the future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with CAD is not clear.
The aim of this study is to investigate the genetic loci, or gene variations contributing to the development and prognosis of CAD in Chinese young adult. Investigators will compare the angiogram results to genetic findings first in patients with different stages of CAD. Then, investigators will collect patients from hospital discharge registry, and compare long-term outcome as well as on operative details in different gene groups.
The results of the study provide a possibility to develop a gene test to recognize patients at risk at its early stage, and needing for preventive medicine.
Tipo de estudo
Inscrição (Antecipado)
Contactos e Locais
Locais de estudo
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Beijing
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Beijing, Beijing, China
- Recrutamento
- China-Japan Friendship Hospital
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Contato:
- Jingang Zheng
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Fujian
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Xiamen, Fujian, China
- Recrutamento
- Xiamen Cardiovascular Hospital
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Contato:
- Yan Wang
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Gansu
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Lanzhou, Gansu, China
- Recrutamento
- The First Hospital of Lanzhou University
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Contato:
- Zheng Zhang
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Guangdong
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Guangzhou, Guangdong, China
- Recrutamento
- Guangdong Provincial People's Hospital
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Contato:
- Yingling Zhou
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Guangzhou, Guangdong, China
- Recrutamento
- Sun Yat-sen Memorial Hospital
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Contato:
- Jingfeng Wang
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Zhuhai, Guangdong, China
- Recrutamento
- Zhuhai Hospital of Guangdong Provincial People's Hospital
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Contato:
- Yingling Zhou
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Guangxi
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Nanning, Guangxi, China
- Recrutamento
- The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine
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Contato:
- Guixin He
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Guizhou
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Zunyi, Guizhou, China
- Recrutamento
- Affiliated Hospital of Zunyi Medical College
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Contato:
- Bei Shi
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Hebei
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Shijiazhuang, Hebei, China
- Recrutamento
- The Second Hospital of Hebei Medical University
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Contato:
- Yongjun Li
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Hubei
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Wuhan, Hubei, China
- Recrutamento
- Wuhan Asia Heart Hospital
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Contato:
- Xi Su
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Jiangsu
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Wuxi, Jiangsu, China
- Recrutamento
- Wuxi Third People's Hospital
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Contato:
- Xiaoyan Wang
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Xuzhou, Jiangsu, China
- Recrutamento
- Xuzhou Fourth People's Hospital
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Contato:
- Yijie Huang
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Jiangxi
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Nanchang, Jiangxi, China
- Recrutamento
- The First Affiliated Hospital of Nanchang University
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Contato:
- Zeqi Zheng
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Jilin
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Chang chun, Jilin, China
- Recrutamento
- The Second Hospital of Jilin University
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Contato:
- Bin Liu
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Ningxia
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Yinchuan, Ningxia, China
- Recrutamento
- General Hospital of Ningxia Medical University
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Contato:
- Shaobin Jia
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Shaanxi
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Xi'an, Shaanxi, China
- Recrutamento
- The First Affiliated Hospital of Xi 'an Jiaotong University
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Contato:
- Yanni Wang
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Shanghai
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Shanghai, Shanghai, China, 200032
- Recrutamento
- Shanghai Zhongshan Hospital
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Investigador principal:
- Junbo Ge, Professor
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Contato:
- Kang Yao
- Número de telefone: 86-13818988550
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Contato:
- Yuxiang Dai
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Shanghai, Shanghai, China
- Recrutamento
- Shanghai Chest Hospital
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Contato:
- Ben He
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Shanghai, Shanghai, China
- Recrutamento
- Shanghai Sixth People's Hospital
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Contato:
- Chengxing Shen
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Shanghai, Shanghai, China
- Recrutamento
- Shanghai Changzheng Hospital
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Shanghai, Shanghai, China
- Recrutamento
- Tenth People's Hospital of Tongji University
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Contato:
- Yawei Xu
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Shanghai, Shanghai, China
- Recrutamento
- Tongji Hospital of Tongji University
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Contato:
- Xuebo Liu
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Shanghai, Shanghai, China
- Recrutamento
- Shanghai Tongren Hospital
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Contato:
- Zening Shen
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Shanghai, Shanghai, China
- Recrutamento
- Central Hospital of Jiading District
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Contato:
- Xiangdong Xu
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Shanghai, Shanghai, China
- Recrutamento
- Central Hospital of Minhang District
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Shanghai, Shanghai, China
- Recrutamento
- Central Hospital of Yangpu District
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Contato:
- Pengxiang Zheng
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Shanghai, Shanghai, China
- Recrutamento
- Changhai Hospital of Second Military Medical University of Chinese PLA
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Contato:
- Xianxian Zhao
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Shanghai, Shanghai, China
- Recrutamento
- Shanghai First People's Hospital
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Contato:
- Shaowen Liu
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Shanghai, Shanghai, China
- Recrutamento
- Shanghai Ninth People's Hospital
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Shanghai, Shanghai, China
- Recrutamento
- Shanghai Shidong Hospital
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Contato:
- Liuliu Feng
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Shanghai, Shanghai, China
- Recrutamento
- Yueyang Hospital
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Contato:
- Min Fan
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Shanxi
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Taiyuan, Shanxi, China
- Recrutamento
- Shanxi Cardiovascular Hospital
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Contato:
- Xuebin Han
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Taiyuan, Shanxi, China
- Recrutamento
- Taiyuan Central Hospital
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Contato:
- Dengfeng Ma
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Tianjin
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Tianjin, Tianjin, China
- Recrutamento
- Tianjin Chest Hospital
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Contato:
- Yin Liu
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Xinjiang
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Karamay, Xinjiang, China
- Recrutamento
- Karamay Central Hospital
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Contato:
- Xiaohong Liu
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Yunnan
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Kunming, Yunnan, China
- Ativo, não recrutando
- Yan'an Hospital of Kunming City
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Zhejiang
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Hangzhou, Zhejiang, China
- Recrutamento
- Second Affiliated Hospital of Zhejiang University
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Zhenjiang
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Hangzhou, Zhenjiang, China
- Recrutamento
- Zhenjiang First People's Hospital
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Contato:
- Guohui Zhang
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Critérios de participação
Critérios de elegibilidade
Idades elegíveis para estudo
Aceita Voluntários Saudáveis
Gêneros Elegíveis para o Estudo
Método de amostragem
População do estudo
Descrição
Inclusion criteria:
- premature CAD, includes patients who aged ≥ 18 and ≤ 45 years , and with at least one main coronary artery stenosis ≥ 50% confirmed by coronary angiography, involving left main coronary artery, left anterior descending branch, left circumflex branch or right coronary artery, and manifested as occult CAD, stable CAD, unstable angina pectoris, non-ST segment elevated myocardial infarction and ST segment elevated myocardial infarction;
- mature CAD, refers to patients who aged ≥ 65 years and meat the same CAD diagnostic criteria as above;
- age matched individuals who had coronary arteries without obvious stenosis.
Exclusion criteria:
- severely sick with limited life-expectancy < 1 year;
- patients with malignancies;
- pregnant or planning for pregnancy.
Plano de estudo
Como o estudo é projetado?
Detalhes do projeto
Coortes e Intervenções
Grupo / Coorte |
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Early-onset CAD
The anticipated 2000 young CAD patients who aged ≤45years undergoing coronary angiography will be recruited in the prospective cohort.
Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.
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Late-onset CAD
The anticipated 2000 old CAD patients aged≥65years undergoing coronary angiography will be recruited in the prospective cohort.
Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.
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Age-matched controls
The anticipated 2000 control subjects without obvious coronary stenosis aged≤45years or ≥65years will be recruited in the prospective cohort.
Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.
|
O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
---|---|---|
Number of cardiac death
Prazo: 36 months
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Any death from cardiac conditions
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36 months
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Number of patients developing myocardial infarction
Prazo: 36 months
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Any case of acute myocardial infarction which meet the Criteria according to current guidelines.
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36 months
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Number of patients developing stroke
Prazo: 36 months
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Any events of ishcemic stroke, TIA or hemorrhagic stroke
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36 months
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Number of participants undergoing unscheduled repeat revascularization of target or non-target vessel
Prazo: 36 months
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Any unshceduled percutaneous coronary intervention or coronary artery bypass grafting after primary revascularization
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36 months
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Medidas de resultados secundários
Medida de resultado |
Descrição da medida |
Prazo |
---|---|---|
Number of stent thrombosis, bleeding、non-cardiac death and all-cause death.
Prazo: 36 months
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Composite of stent thrombosis, bleeding、non-cardiac death and all-cause death.
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36 months
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Colaboradores e Investigadores
Patrocinador
Datas de registro do estudo
Datas Principais do Estudo
Início do estudo (Real)
Conclusão Primária (Antecipado)
Conclusão do estudo (Antecipado)
Datas de inscrição no estudo
Enviado pela primeira vez
Enviado pela primeira vez que atendeu aos critérios de CQ
Primeira postagem (Estimativa)
Atualizações de registro de estudo
Última Atualização Postada (Real)
Última atualização enviada que atendeu aos critérios de controle de qualidade
Última verificação
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Termos MeSH relevantes adicionais
Outros números de identificação do estudo
- ZS-CV-2015
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