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Clinical and Genetic Characteristics of Coronary Artery Disease in Chinese Young Adults (GRAND)

20 februari 2019 uppdaterad av: Junbo Ge, Shanghai Zhongshan Hospital
The aim of this study is to identify genetic loci,or gene variations contributing to the development of coronary artery disease (CAD) in Chinese young adults. Investigators will compare coronary angiogram results to genetic findings within young CAD patients.

Studieöversikt

Status

Okänd

Betingelser

Detaljerad beskrivning

During last 10 years, the rise in coronary artery disease (CAD) prevalence in Chinese young adults is observed and percutaneous coronary intervention (PCI) is generally considered to be low operative risk in these young patients. Genome-wide association studies have identified a considerable number of common genetic variants related to CAD. However, the extent to which these genetic variants are related to the future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with CAD is not clear.

The aim of this study is to investigate the genetic loci, or gene variations contributing to the development and prognosis of CAD in Chinese young adult. Investigators will compare the angiogram results to genetic findings first in patients with different stages of CAD. Then, investigators will collect patients from hospital discharge registry, and compare long-term outcome as well as on operative details in different gene groups.

The results of the study provide a possibility to develop a gene test to recognize patients at risk at its early stage, and needing for preventive medicine.

Studietyp

Observationell

Inskrivning (Förväntat)

2000

Kontakter och platser

Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.

Studieorter

  • Kina
    • Beijing
      • Beijing, Beijing, Kina
        • Rekrytering
        • China-Japan Friendship Hospital
        • Kontakt:
          • Jingang Zheng
    • Fujian
      • Xiamen, Fujian, Kina
        • Rekrytering
        • Xiamen Cardiovascular Hospital
        • Kontakt:
          • Yan Wang
    • Gansu
      • Lanzhou, Gansu, Kina
        • Rekrytering
        • The First Hospital of Lanzhou University
        • Kontakt:
          • Zheng Zhang
    • Guangdong
      • Guangzhou, Guangdong, Kina
        • Rekrytering
        • Guangdong Provincial People's Hospital
        • Kontakt:
          • Yingling Zhou
      • Guangzhou, Guangdong, Kina
        • Rekrytering
        • Sun Yat-sen Memorial Hospital
        • Kontakt:
          • Jingfeng Wang
      • Zhuhai, Guangdong, Kina
        • Rekrytering
        • Zhuhai Hospital of Guangdong Provincial People's Hospital
        • Kontakt:
          • Yingling Zhou
    • Guangxi
      • Nanning, Guangxi, Kina
        • Rekrytering
        • The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine
        • Kontakt:
          • Guixin He
    • Guizhou
      • Zunyi, Guizhou, Kina
        • Rekrytering
        • Affiliated Hospital of Zunyi Medical College
        • Kontakt:
          • Bei Shi
    • Hebei
      • Shijiazhuang, Hebei, Kina
        • Rekrytering
        • The Second Hospital of Hebei Medical University
        • Kontakt:
          • Yongjun Li
    • Hubei
      • Wuhan, Hubei, Kina
        • Rekrytering
        • Wuhan Asia Heart Hospital
        • Kontakt:
          • Xi Su
    • Jiangsu
      • Wuxi, Jiangsu, Kina
        • Rekrytering
        • Wuxi Third People's Hospital
        • Kontakt:
          • Xiaoyan Wang
      • Xuzhou, Jiangsu, Kina
        • Rekrytering
        • Xuzhou Fourth People's Hospital
        • Kontakt:
          • Yijie Huang
    • Jiangxi
      • Nanchang, Jiangxi, Kina
        • Rekrytering
        • The First Affiliated Hospital of Nanchang University
        • Kontakt:
          • Zeqi Zheng
    • Jilin
      • Chang chun, Jilin, Kina
        • Rekrytering
        • The Second Hospital of Jilin University
        • Kontakt:
          • Bin Liu
    • Ningxia
      • Yinchuan, Ningxia, Kina
        • Rekrytering
        • General Hospital of Ningxia Medical University
        • Kontakt:
          • Shaobin Jia
    • Shaanxi
      • Xi'an, Shaanxi, Kina
        • Rekrytering
        • The First Affiliated Hospital of Xi 'an Jiaotong University
        • Kontakt:
          • Yanni Wang
    • Shanghai
      • Shanghai, Shanghai, Kina, 200032
        • Rekrytering
        • Shanghai Zhongshan Hospital
        • Huvudutredare:
          • Junbo Ge, Professor
        • Kontakt:
          • Kang Yao
          • Telefonnummer: 86-13818988550
        • Kontakt:
          • Yuxiang Dai
      • Shanghai, Shanghai, Kina
        • Rekrytering
        • Shanghai Chest Hospital
        • Kontakt:
          • Ben He
      • Shanghai, Shanghai, Kina
        • Rekrytering
        • Shanghai Sixth People's Hospital
        • Kontakt:
          • Chengxing Shen
      • Shanghai, Shanghai, Kina
        • Rekrytering
        • Shanghai Changzheng Hospital
      • Shanghai, Shanghai, Kina
        • Rekrytering
        • Tenth People's Hospital of Tongji University
        • Kontakt:
          • Yawei Xu
      • Shanghai, Shanghai, Kina
        • Rekrytering
        • Tongji Hospital of Tongji University
        • Kontakt:
          • Xuebo Liu
      • Shanghai, Shanghai, Kina
        • Rekrytering
        • Shanghai Tongren Hospital
        • Kontakt:
          • Zening Shen
      • Shanghai, Shanghai, Kina
        • Rekrytering
        • Central Hospital of Jiading District
        • Kontakt:
          • Xiangdong Xu
      • Shanghai, Shanghai, Kina
        • Rekrytering
        • Central Hospital of Minhang District
      • Shanghai, Shanghai, Kina
        • Rekrytering
        • Central Hospital of Yangpu District
        • Kontakt:
          • Pengxiang Zheng
      • Shanghai, Shanghai, Kina
        • Rekrytering
        • Changhai Hospital of Second Military Medical University of Chinese PLA
        • Kontakt:
          • Xianxian Zhao
      • Shanghai, Shanghai, Kina
        • Rekrytering
        • Shanghai First People's Hospital
        • Kontakt:
          • Shaowen Liu
      • Shanghai, Shanghai, Kina
        • Rekrytering
        • Shanghai Ninth People's Hospital
      • Shanghai, Shanghai, Kina
        • Rekrytering
        • Shanghai Shidong Hospital
        • Kontakt:
          • Liuliu Feng
      • Shanghai, Shanghai, Kina
        • Rekrytering
        • Yueyang Hospital
        • Kontakt:
          • Min Fan
    • Shanxi
      • Taiyuan, Shanxi, Kina
        • Rekrytering
        • Shanxi Cardiovascular Hospital
        • Kontakt:
          • Xuebin Han
      • Taiyuan, Shanxi, Kina
        • Rekrytering
        • Taiyuan Central Hospital
        • Kontakt:
          • Dengfeng Ma
    • Tianjin
      • Tianjin, Tianjin, Kina
        • Rekrytering
        • Tianjin Chest Hospital
        • Kontakt:
          • Yin Liu
    • Xinjiang
      • Karamay, Xinjiang, Kina
        • Rekrytering
        • Karamay Central Hospital
        • Kontakt:
          • Xiaohong Liu
    • Yunnan
      • Kunming, Yunnan, Kina
        • Aktiv, inte rekryterande
        • Yan'an Hospital of Kunming City
    • Zhejiang
      • Hangzhou, Zhejiang, Kina
        • Rekrytering
        • Second Affiliated Hospital of Zhejiang University
    • Zhenjiang
      • Hangzhou, Zhenjiang, Kina
        • Rekrytering
        • Zhenjiang First People's Hospital
        • Kontakt:
          • Guohui Zhang

Deltagandekriterier

Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.

Urvalskriterier

Åldrar som är berättigade till studier

18 år till 45 år (Vuxen)

Tar emot friska volontärer

Ja

Kön som är behöriga för studier

Allt

Testmetod

Sannolikhetsprov

Studera befolkning

Patients aged ≤45 years diagnosed with CAD by coronary angiography will be collected from multiple institutions.

Beskrivning

Inclusion criteria:

  1. premature CAD, includes patients who aged ≥ 18 and ≤ 45 years , and with at least one main coronary artery stenosis ≥ 50% confirmed by coronary angiography, involving left main coronary artery, left anterior descending branch, left circumflex branch or right coronary artery, and manifested as occult CAD, stable CAD, unstable angina pectoris, non-ST segment elevated myocardial infarction and ST segment elevated myocardial infarction;
  2. mature CAD, refers to patients who aged ≥ 65 years and meat the same CAD diagnostic criteria as above;
  3. age matched individuals who had coronary arteries without obvious stenosis.

Exclusion criteria:

  1. severely sick with limited life-expectancy < 1 year;
  2. patients with malignancies;
  3. pregnant or planning for pregnancy.

Studieplan

Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.

Hur är studien utformad?

Designdetaljer

Kohorter och interventioner

Grupp / Kohort
Early-onset CAD
The anticipated 2000 young CAD patients who aged ≤45years undergoing coronary angiography will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.
Late-onset CAD
The anticipated 2000 old CAD patients aged≥65years undergoing coronary angiography will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.
Age-matched controls
The anticipated 2000 control subjects without obvious coronary stenosis aged≤45years or ≥65years will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.

Vad mäter studien?

Primära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
Number of cardiac death
Tidsram: 36 months
Any death from cardiac conditions
36 months
Number of patients developing myocardial infarction
Tidsram: 36 months
Any case of acute myocardial infarction which meet the Criteria according to current guidelines.
36 months
Number of patients developing stroke
Tidsram: 36 months
Any events of ishcemic stroke, TIA or hemorrhagic stroke
36 months
Number of participants undergoing unscheduled repeat revascularization of target or non-target vessel
Tidsram: 36 months
Any unshceduled percutaneous coronary intervention or coronary artery bypass grafting after primary revascularization
36 months

Sekundära resultatmått

Resultatmått
Åtgärdsbeskrivning
Tidsram
Number of stent thrombosis, bleeding、non-cardiac death and all-cause death.
Tidsram: 36 months
Composite of stent thrombosis, bleeding、non-cardiac death and all-cause death.
36 months

Samarbetspartners och utredare

Det är här du hittar personer och organisationer som är involverade i denna studie.

Sponsor

Shanghai Zhongshan Hospital

Studieavstämningsdatum

Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.

Studera stora datum

Studiestart (Faktisk)

12 maj 2017

Primärt slutförande (Förväntat)

1 maj 2019

Avslutad studie (Förväntat)

1 maj 2022

Studieregistreringsdatum

Först inskickad

7 juli 2015

Först inskickad som uppfyllde QC-kriterierna

9 juli 2015

Första postat (Uppskatta)

14 juli 2015

Uppdateringar av studier

Senaste uppdatering publicerad (Faktisk)

21 februari 2019

Senaste inskickade uppdateringen som uppfyllde QC-kriterierna

20 februari 2019

Senast verifierad

1 februari 2019

Mer information

Termer relaterade till denna studie

Nyckelord

Ytterligare relevanta MeSH-villkor

Andra studie-ID-nummer

  • ZS-CV-2015

Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .

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