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Clinical and Genetic Characteristics of Coronary Artery Disease in Chinese Young Adults (GRAND)

20. februar 2019 oppdatert av: Junbo Ge, Shanghai Zhongshan Hospital
The aim of this study is to identify genetic loci,or gene variations contributing to the development of coronary artery disease (CAD) in Chinese young adults. Investigators will compare coronary angiogram results to genetic findings within young CAD patients.

Studieoversikt

Status

Ukjent

Forhold

Detaljert beskrivelse

During last 10 years, the rise in coronary artery disease (CAD) prevalence in Chinese young adults is observed and percutaneous coronary intervention (PCI) is generally considered to be low operative risk in these young patients. Genome-wide association studies have identified a considerable number of common genetic variants related to CAD. However, the extent to which these genetic variants are related to the future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with CAD is not clear.

The aim of this study is to investigate the genetic loci, or gene variations contributing to the development and prognosis of CAD in Chinese young adult. Investigators will compare the angiogram results to genetic findings first in patients with different stages of CAD. Then, investigators will collect patients from hospital discharge registry, and compare long-term outcome as well as on operative details in different gene groups.

The results of the study provide a possibility to develop a gene test to recognize patients at risk at its early stage, and needing for preventive medicine.

Studietype

Observasjonsmessig

Registrering (Forventet)

2000

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

  • Kina
    • Beijing
      • Beijing, Beijing, Kina
        • Rekruttering
        • China-Japan Friendship hospital
        • Ta kontakt med:
          • Jingang Zheng
    • Fujian
      • Xiamen, Fujian, Kina
        • Rekruttering
        • Xiamen Cardiovascular Hospital
        • Ta kontakt med:
          • Yan Wang
    • Gansu
      • Lanzhou, Gansu, Kina
        • Rekruttering
        • The First Hospital of Lanzhou University
        • Ta kontakt med:
          • Zheng Zhang
    • Guangdong
      • Guangzhou, Guangdong, Kina
        • Rekruttering
        • Guangdong Provincial People's Hospital
        • Ta kontakt med:
          • Yingling Zhou
      • Guangzhou, Guangdong, Kina
        • Rekruttering
        • Sun Yat-sen Memorial Hospital
        • Ta kontakt med:
          • Jingfeng Wang
      • Zhuhai, Guangdong, Kina
        • Rekruttering
        • Zhuhai Hospital of Guangdong Provincial People's Hospital
        • Ta kontakt med:
          • Yingling Zhou
    • Guangxi
      • Nanning, Guangxi, Kina
        • Rekruttering
        • The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine
        • Ta kontakt med:
          • Guixin He
    • Guizhou
      • Zunyi, Guizhou, Kina
        • Rekruttering
        • Affiliated hospital of ZunYi medical college
        • Ta kontakt med:
          • Bei Shi
    • Hebei
      • Shijiazhuang, Hebei, Kina
        • Rekruttering
        • The Second Hospital of Hebei Medical University
        • Ta kontakt med:
          • Yongjun Li
    • Hubei
      • Wuhan, Hubei, Kina
        • Rekruttering
        • Wuhan Asia Heart Hospital
        • Ta kontakt med:
          • Xi Su
    • Jiangsu
      • Wuxi, Jiangsu, Kina
        • Rekruttering
        • Wuxi Third People's Hospital
        • Ta kontakt med:
          • Xiaoyan Wang
      • Xuzhou, Jiangsu, Kina
        • Rekruttering
        • Xuzhou Fourth People's Hospital
        • Ta kontakt med:
          • Yijie Huang
    • Jiangxi
      • Nanchang, Jiangxi, Kina
        • Rekruttering
        • The First Affiliated Hospital of Nanchang University
        • Ta kontakt med:
          • Zeqi Zheng
    • Jilin
      • Chang chun, Jilin, Kina
        • Rekruttering
        • The Second Hospital of Jilin University
        • Ta kontakt med:
          • Bin Liu
    • Ningxia
      • Yinchuan, Ningxia, Kina
        • Rekruttering
        • General Hospital Of Ningxia Medical University
        • Ta kontakt med:
          • Shaobin Jia
    • Shaanxi
      • Xi'an, Shaanxi, Kina
        • Rekruttering
        • The First Affiliated Hospital of Xi 'an Jiaotong University
        • Ta kontakt med:
          • Yanni Wang
    • Shanghai
      • Shanghai, Shanghai, Kina, 200032
        • Rekruttering
        • Shanghai Zhongshan Hospital
        • Hovedetterforsker:
          • Junbo Ge, Professor
        • Ta kontakt med:
          • Kang Yao
          • Telefonnummer: 86-13818988550
        • Ta kontakt med:
          • Yuxiang Dai
      • Shanghai, Shanghai, Kina
        • Rekruttering
        • Shanghai Chest Hospital
        • Ta kontakt med:
          • Ben He
      • Shanghai, Shanghai, Kina
        • Rekruttering
        • Shanghai Sixth People's Hospital
        • Ta kontakt med:
          • Chengxing Shen
      • Shanghai, Shanghai, Kina
        • Rekruttering
        • Shanghai Changzheng Hospital
      • Shanghai, Shanghai, Kina
        • Rekruttering
        • Tenth People's Hospital of Tongji University
        • Ta kontakt med:
          • Yawei Xu
      • Shanghai, Shanghai, Kina
        • Rekruttering
        • Tongji Hospital of Tongji University
        • Ta kontakt med:
          • Xuebo Liu
      • Shanghai, Shanghai, Kina
        • Rekruttering
        • Shanghai Tongren Hospital
        • Ta kontakt med:
          • Zening Shen
      • Shanghai, Shanghai, Kina
        • Rekruttering
        • Central Hospital of Jiading District
        • Ta kontakt med:
          • Xiangdong Xu
      • Shanghai, Shanghai, Kina
        • Rekruttering
        • Central Hospital of Minhang District
      • Shanghai, Shanghai, Kina
        • Rekruttering
        • Central Hospital of Yangpu District
        • Ta kontakt med:
          • Pengxiang Zheng
      • Shanghai, Shanghai, Kina
        • Rekruttering
        • Changhai Hospital of Second Military Medical University of Chinese PLA
        • Ta kontakt med:
          • Xianxian Zhao
      • Shanghai, Shanghai, Kina
        • Rekruttering
        • Shanghai First People's Hospital
        • Ta kontakt med:
          • Shaowen Liu
      • Shanghai, Shanghai, Kina
        • Rekruttering
        • Shanghai Ninth People's Hospital
      • Shanghai, Shanghai, Kina
        • Rekruttering
        • Shanghai Shidong Hospital
        • Ta kontakt med:
          • Liuliu Feng
      • Shanghai, Shanghai, Kina
        • Rekruttering
        • Yueyang Hospital
        • Ta kontakt med:
          • Min Fan
    • Shanxi
      • Taiyuan, Shanxi, Kina
        • Rekruttering
        • Shanxi Cardiovascular Hospital
        • Ta kontakt med:
          • Xuebin Han
      • Taiyuan, Shanxi, Kina
        • Rekruttering
        • Taiyuan Central Hospital
        • Ta kontakt med:
          • Dengfeng Ma
    • Tianjin
      • Tianjin, Tianjin, Kina
        • Rekruttering
        • Tianjin Chest Hospital
        • Ta kontakt med:
          • Yin Liu
    • Xinjiang
      • Karamay, Xinjiang, Kina
        • Rekruttering
        • Karamay Central Hospital
        • Ta kontakt med:
          • Xiaohong Liu
    • Yunnan
      • Kunming, Yunnan, Kina
        • Aktiv, ikke rekrutterende
        • Yan'an Hospital of Kunming City
    • Zhejiang
      • Hangzhou, Zhejiang, Kina
        • Rekruttering
        • Second Affiliated Hospital of Zhejiang University
    • Zhenjiang
      • Hangzhou, Zhenjiang, Kina
        • Rekruttering
        • Zhenjiang First People's Hospital
        • Ta kontakt med:
          • Guohui Zhang

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år til 45 år (Voksen)

Tar imot friske frivillige

Ja

Kjønn som er kvalifisert for studier

Alle

Prøvetakingsmetode

Sannsynlighetsprøve

Studiepopulasjon

Patients aged ≤45 years diagnosed with CAD by coronary angiography will be collected from multiple institutions.

Beskrivelse

Inclusion criteria:

  1. premature CAD, includes patients who aged ≥ 18 and ≤ 45 years , and with at least one main coronary artery stenosis ≥ 50% confirmed by coronary angiography, involving left main coronary artery, left anterior descending branch, left circumflex branch or right coronary artery, and manifested as occult CAD, stable CAD, unstable angina pectoris, non-ST segment elevated myocardial infarction and ST segment elevated myocardial infarction;
  2. mature CAD, refers to patients who aged ≥ 65 years and meat the same CAD diagnostic criteria as above;
  3. age matched individuals who had coronary arteries without obvious stenosis.

Exclusion criteria:

  1. severely sick with limited life-expectancy < 1 year;
  2. patients with malignancies;
  3. pregnant or planning for pregnancy.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Kohorter og intervensjoner

Gruppe / Kohort
Early-onset CAD
The anticipated 2000 young CAD patients who aged ≤45years undergoing coronary angiography will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.
Late-onset CAD
The anticipated 2000 old CAD patients aged≥65years undergoing coronary angiography will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.
Age-matched controls
The anticipated 2000 control subjects without obvious coronary stenosis aged≤45years or ≥65years will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Number of cardiac death
Tidsramme: 36 months
Any death from cardiac conditions
36 months
Number of patients developing myocardial infarction
Tidsramme: 36 months
Any case of acute myocardial infarction which meet the Criteria according to current guidelines.
36 months
Number of patients developing stroke
Tidsramme: 36 months
Any events of ishcemic stroke, TIA or hemorrhagic stroke
36 months
Number of participants undergoing unscheduled repeat revascularization of target or non-target vessel
Tidsramme: 36 months
Any unshceduled percutaneous coronary intervention or coronary artery bypass grafting after primary revascularization
36 months

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Number of stent thrombosis, bleeding、non-cardiac death and all-cause death.
Tidsramme: 36 months
Composite of stent thrombosis, bleeding、non-cardiac death and all-cause death.
36 months

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Shanghai Zhongshan Hospital

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

12. mai 2017

Primær fullføring (Forventet)

1. mai 2019

Studiet fullført (Forventet)

1. mai 2022

Datoer for studieregistrering

Først innsendt

7. juli 2015

Først innsendt som oppfylte QC-kriteriene

9. juli 2015

Først lagt ut (Anslag)

14. juli 2015

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

21. februar 2019

Siste oppdatering sendt inn som oppfylte QC-kriteriene

20. februar 2019

Sist bekreftet

1. februar 2019

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • ZS-CV-2015

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

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Forhold

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