Effect of Transcranial Direct Current Stimulation on Peripheral Neuropathy
Effect of Transcranial Direct Current Stimulation on Proprioceptive and Vibratory Sensation: Potential Benefit for Patients With Peripheral Neuropathy
研究概览
详细说明
This study will be performed in patients with peripheral neuropathy who are walking independently, but have complains of balance problems such as recent falls or difficulty walking and show reduced vibratory and proprioceptive sensation during routine neurologic examination. These patients will be tested for proprioceptive and vibratory threshold at the toes and ankles before, during and after receiving anodal transcranial direct current stimulation (tDCS) over sensory and motor cortices. Subjects will be asked to participate in 2 sessions. In one of the sessions, decided randomly, the stimulation will be applied on the right side and in the second session it will be on the left.
The tDCS portion of the experiment will begins with direct current (maximum of 2 mA) stimulation delivered through surface electrodes (TransQE from IOMED®, surface area: 25 cm2) using a Phoresor® II Auto (Model No. PM850, IOMED®, Salt Lake City, Utah 84120, USA). One electrode will be positioned above the left or right primary motor cortex, the other electrode over the forehead.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Maryland
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Baltimore、Maryland、美国、21287
- Johns Hopkins Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Peripheral Neuropathy
- Walking independently but with problems with balance
Exclusion Criteria:
- Prominent weakness at the ankle
- Not able to walk independently
- History of Seizure
- Cardiac Pacemaker
- Metal implants in the head
- Increased intracranial pressure
- Pregnancy
学习计划
研究是如何设计的？
设计细节
- 主要用途：支持治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
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实验性的：dTCS
Patient will receive dTCS with direct current (maximum of 2 mA) stimulation delivered through surface electrodes (TransQE from IOMED®, surface area: 25 cm2) using a Phoresor® II Auto (Model No. PM850, IOMED®, Salt Lake City, Utah 84120, USA) or Sham stimulation.
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Direct current (DC) (maximum of 2 mA) stimulation delivered through surface electrodes.
One electrode will be positioned above the left or right primary motor cortex, the other electrode over the forehead.
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假比较器：Sham
Patients will receive a sham.
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The device will administer a sham.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Change in Vibratory Threshold as Measured by Rydel Seiffer Graduated Tuning Fork at the Toes
大体时间：At 10 and 20 minutes
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Vibration is measured by reading in Rydel Seiffer tuning fork that ranges between 0-8 and is a standard tool fro measuring vibration sensation at the toes.
A reading of 0 means absent vibration.
A reading of more than 4 at the toes are considered normal.
Change between assessment at 20 minutes and 10 minutes at the toes will be assessed.
A recording of less than 4 indicates an abnormal results and a lower number means worse neuropathy.
For example, reading of 0 means absent vibration feeling which indicates worse neuropathy than a reading of 2.
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At 10 and 20 minutes
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Change in Minimum Detectable Angle (Degree) of Dorsiflexion of the Toe
大体时间：At 10 and 20 minutes
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At 10 and 20 minutes
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合作者和调查者
调查人员
- 首席研究员：Mohammad Khoshnoodi, MD、Johns Hopkins University
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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