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Longitudinal Interaction Between APOA5 -1131T>C and Overweight Accelerates Arterial Stiffness

2017年12月4日更新者：Jong Ho Lee、Yonsei University

Longitudinal Interaction Between APOA5 -1131T>C and Overweight

The aim of this study is to evaluate whether the longitudinal interaction between APOA5 -1131C variants and overweight could accelerate age-related increases in arterial stiffness and circulating triglycerides in healthy subjects.

研究概览

地位

完全的

条件

超重和肥胖

干预/治疗

遗传的：rs662799 (APOA5 -1131T>C)

研究类型

观察性的

注册 (实际的)

503

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

30年至 65年 (成人、年长者)

接受健康志愿者

是的

有资格学习的性别

全部

取样方法

概率样本

研究人群

We performed a 3-year prospective cohort study that included 800 heathy subjects (30-65 years old), of these, 503 nondiabetic and nonobese individuals were finally selected.

描述

Inclusion Criteria:

Nondiabetic (fasting serum glucose concentration < 126 mg/dL)
Nonobese (BMI ≥ 25 kg/m2)

Exclusion Criteria:

Current and/or past history of cardiovascular disease
Diabetes mellitus (fasting glucose levels ≥126 mg/dL)
Abnormal liver or renal function
Thyroid or pituitary disease
Pregnancy or lactation
Regular use of any medication

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

团体/队列数

队列和干预

团体/队列	干预/治疗
Normal weight nondiabetic and nonobese individuals (18.5 kg/m2 ≤ BMI < 25 kg/m2, n=349)	遗传的：rs662799 (APOA5 -1131T>C) Among the 349 normal-weight individuals, 168 were homozygous (TT) for the T allele, 155 were heterozygous for the C allele (TC) and 26 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism. Among the 154 overweight individuals, 68 were homozygous (TT) for the T allele, 75 were heterozygous for the C allele (TC) and 11 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism.
Overweight nondiabetic and nonobese individuals (25 kg/m2 ≤ BMI < 30 kg/m2, n=154)	遗传的：rs662799 (APOA5 -1131T>C) Among the 349 normal-weight individuals, 168 were homozygous (TT) for the T allele, 155 were heterozygous for the C allele (TC) and 26 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism. Among the 154 overweight individuals, 68 were homozygous (TT) for the T allele, 75 were heterozygous for the C allele (TC) and 11 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism.

团体/队列

干预/治疗

Normal weight

nondiabetic and nonobese individuals (18.5 kg/m2 ≤ BMI < 25 kg/m2, n=349)

遗传的：rs662799 (APOA5 -1131T>C)

Among the 349 normal-weight individuals, 168 were homozygous (TT) for the T allele, 155 were heterozygous for the C allele (TC) and 26 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism. Among the 154 overweight individuals, 68 were homozygous (TT) for the T allele, 75 were heterozygous for the C allele (TC) and 11 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism.

Overweight

nondiabetic and nonobese individuals (25 kg/m2 ≤ BMI < 30 kg/m2, n=154)

遗传的：rs662799 (APOA5 -1131T>C)

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
Brachial-ankle PWV (baPWV) 大体时间：at baseline	cm/s	at baseline
Brachial-ankle PWV (baPWV) 大体时间：3-year follow-up	cm/s	3-year follow-up

次要结果测量

结果测量	措施说明	大体时间
Triglyceride 大体时间：at baseline	mg/dL	at baseline
Triglyceride 大体时间：3-year follow-up	mg/dL	3-year follow-up

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Yonsei University

调查人员

首席研究员：Jong Ho Lee, PhD、Dept. of Food and Nutrition, Colleage of Human Ecology, Yonsei University

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2008年1月1日

初级完成 (实际的)

2013年12月1日

研究完成 (实际的)

2013年12月31日

研究注册日期

首次提交

2017年12月4日

首先提交符合 QC 标准的

2017年12月4日

首次发布 (实际的)

2017年12月8日

研究记录更新

最后更新发布 (实际的)

2017年12月8日

上次提交的符合 QC 标准的更新

2017年12月4日

最后验证

2017年12月1日

Longitudinal Interaction Between APOA5 -1131T>C and Overweight Accelerates Arterial Stiffness