Genetic Variants and Non-genetic Variables and Postoperative Nausea and Vomiting
Genetic Variants and Non-genetic Variables Associated With Postoperative Nausea and Vomiting (PONV)
研究概览
详细说明
Background
Surgery and anesthesia are related to unwanted adverse events, side effects and postoperative discomfort. Postoperative nausea and vomiting are frequent and the question arises which patient is at specific risk for these sequelae. Some predisposing factors for PONV are well described, e.g. female sex, non-smoking status and postoperative opioids. Some drugs used for anesthesia as well as surgery related variables might induce PONV.
In this prospective association study patient related variables, surgical and anesthesia related variables as well as genetic variants of several candidate genes will be investigated in a well-described patient cohort presenting for scheduled surgery.
Objective
The aim of this study is to investigate a possible association of non-genetic variables and genetic variants with PONV.
Methods
Prospective association study performed in patients recovering form elective surgery and anesthesia.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Bern、瑞士、3010
- Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- 18 years and older
- Written informed consent
- Elective surgery
Exclusion Criteria
- No written informed consent
- Cognitive impairment
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
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All patients
Patients undergoing general anesthesia for elective surgery
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Association study: genetic and non-genetic variables associated with No PONV, Intermediate PONV and Severe PONV
大体时间：perioperative period up to 48 hours after surgery
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PONV composite outcome measured by episodes of vomiting and nausea + need for antiemetic treatment + results of a patient reported outcome questionnaire.
Patients with no PONV are compared to those with intermediate and severe PONV.
Bariatric patients will not be included in this analysis.
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perioperative period up to 48 hours after surgery
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Sex specific association analysis: Severity of PONV associated with genetic and non-genetic variables in males and females
大体时间：perioperative period up to 48 hours after surgery
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PONV composite outcome measured by episodes of vomiting and nausea + need for antiemetic treatment + results of a patient reported outcome.
questionnaire.
Patients with no PONV are compared to those with intermediate and severe PONV
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perioperative period up to 48 hours after surgery
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Association study in patients undergoing bariatric surgery: genetic and non-genetic variables associated with No PONV, Intermediate PONV and Severe PONV
大体时间：perioperative period up to 48 hours after surgery
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PONV composite outcome measured by episodes of vomiting and nausea + need for antiemetic treatment + results of a patient reported outcome questionnaire.
Patients with no PONV are compared to those with intermediate and severe PONV
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perioperative period up to 48 hours after surgery
|
合作者和调查者
调查人员
- 首席研究员：Ulrike M Stamer, MD、Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern
- 学习椅：Ulrike Stamer, Prof. MD、Department of Anaestheisology and Pain Medicine, Inselspital, University of Bern
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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