Genetic Variants and Non-genetic Variables and Postoperative Nausea and Vomiting
Genetic Variants and Non-genetic Variables Associated With Postoperative Nausea and Vomiting (PONV)
調査の概要
詳細な説明
Background
Surgery and anesthesia are related to unwanted adverse events, side effects and postoperative discomfort. Postoperative nausea and vomiting are frequent and the question arises which patient is at specific risk for these sequelae. Some predisposing factors for PONV are well described, e.g. female sex, non-smoking status and postoperative opioids. Some drugs used for anesthesia as well as surgery related variables might induce PONV.
In this prospective association study patient related variables, surgical and anesthesia related variables as well as genetic variants of several candidate genes will be investigated in a well-described patient cohort presenting for scheduled surgery.
Objective
The aim of this study is to investigate a possible association of non-genetic variables and genetic variants with PONV.
Methods
Prospective association study performed in patients recovering form elective surgery and anesthesia.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Bern、スイス、3010
- Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- 18 years and older
- Written informed consent
- Elective surgery
Exclusion Criteria
- No written informed consent
- Cognitive impairment
研究計画
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
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All patients
Patients undergoing general anesthesia for elective surgery
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Association study: genetic and non-genetic variables associated with No PONV, Intermediate PONV and Severe PONV
時間枠：perioperative period up to 48 hours after surgery
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PONV composite outcome measured by episodes of vomiting and nausea + need for antiemetic treatment + results of a patient reported outcome questionnaire.
Patients with no PONV are compared to those with intermediate and severe PONV.
Bariatric patients will not be included in this analysis.
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perioperative period up to 48 hours after surgery
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Sex specific association analysis: Severity of PONV associated with genetic and non-genetic variables in males and females
時間枠：perioperative period up to 48 hours after surgery
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PONV composite outcome measured by episodes of vomiting and nausea + need for antiemetic treatment + results of a patient reported outcome.
questionnaire.
Patients with no PONV are compared to those with intermediate and severe PONV
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perioperative period up to 48 hours after surgery
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Association study in patients undergoing bariatric surgery: genetic and non-genetic variables associated with No PONV, Intermediate PONV and Severe PONV
時間枠：perioperative period up to 48 hours after surgery
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PONV composite outcome measured by episodes of vomiting and nausea + need for antiemetic treatment + results of a patient reported outcome questionnaire.
Patients with no PONV are compared to those with intermediate and severe PONV
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perioperative period up to 48 hours after surgery
|
協力者と研究者
捜査官
- 主任研究者：Ulrike M Stamer, MD、Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern
- スタディチェア：Ulrike Stamer, Prof. MD、Department of Anaestheisology and Pain Medicine, Inselspital, University of Bern
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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