The Acute Effects of Commercially Available Drinks on the Endothelial Function of Humans Following a High-fat Meal
Pilot Study: The Acute Effects of Commercially Available Drinks on the Endothelial Function of Humans Following a High-fat Meal
High fat diets are associated with impaired endothelial function and increased cardiovascular disease risk amongst our population. These negative effects are likely caused by triglyceride induced suppression of nitric oxide, which is produced from the endothelium, and/or an increase in oxidative stress.
Interestingly, previous studies have found that some beverages that are high in polyphenols and antioxidants may suppress the impairment in endothelial function observed following high fat meals/diets. Typically, these studies have investigated the ingestion of red wine, orange juice or green tea on outcome measures (typically flow mediated dilatation (FMD) of the brachial artery). Despite this previous research, no study has compared the effects of different beverages on endothelial outcomes following a high-fat meal within the same participants.
研究概览
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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-
-
Inverness、英国、IV2 3JH
- University of the Highlands and Islands
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Females to be postmenopausal and not on hormone replacement therapy
- 25 > BMI < 35
- Sedentary to light activity lifestyle.
Exclusion Criteria:
- History of cardiovascular disease (Hypertension, Atherosclerosis, endothelial issues etc).
- History of diabetes (Type 1 or type 2)
- Vegan or with food allergies or intolerances.
- Taking any antioxidants over the counter (Vit C, E or polyphenol supplements)
- Taking prescription medication for hypertension.
学习计划
研究是如何设计的？
设计细节
- 主要用途：预防
- 分配：随机化
- 介入模型：交叉作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
有源比较器：Water + Meal
250 ml Water and a high calorie, high fat meal (>900 kcal, 50g fat)
|
250 ml
|
|
实验性的：Red Wine + Meal
250 ml Red Wine and a high calorie, high fat meal (>900 kcal, 50g fat)
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250 ml
|
|
实验性的：Green Tea + Meal
250 ml Green Tea and a high calorie, high fat meal (>900 kcal, 50g fat)
|
250 ml
|
|
实验性的：Orange Juice + Meal
250 ml Orange Juice and a high calorie, high fat meal (>900 kcal, 50g fat)
|
250 ml
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Endothelial (dys)function
大体时间：2 hours post-prandial
|
Assessed via flow mediated dilatation
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2 hours post-prandial
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Plasma Nitrite
大体时间：2 hours post-prandial
|
2 hours post-prandial
|
|
|
Plasma antioxidant capacity
大体时间：2 hours post-prandial
|
Plasma oxygen radical absorbance capacity
|
2 hours post-prandial
|
|
Plasma ox-LDL
大体时间：2 hours post-prandial
|
2 hours post-prandial
|
合作者和调查者
调查人员
- 首席研究员：Ian Megson, Megson、University of the Highlands and Islands
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.