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Baricitinib (LY3009104) 在类风湿性关节炎患者中的研究 (RA-BRIDGE)

2026年5月27日 更新者：Eli Lilly and Company

Baricitinib 在类风湿性关节炎患者中的随机、主动控制、平行组、3b/4 期研究

这项上市后研究旨在比较巴瑞克替尼与肿瘤坏死因子 (TNF) 抑制剂在静脉血栓栓塞事件 (VTE) 方面对类风湿性关节炎患者的安全性。

研究概览

地位

完全的

条件

干预/治疗

研究类型

介入性

注册 (实际的)

2659

阶段

  • 第四阶段

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 丹麦
    • Central Jutland
      • Silkeborg、Central Jutland、丹麦、8600
        • Regionshospitalet Silkeborg
    • Region Syddanmark
      • Svendborg、Region Syddanmark、丹麦、5700
        • Reumatologisk Ambulatorie, Svendborg Hospital Odense Universitet Hospital
  • 以色列
    • Central District
      • Kfar Saba、Central District、以色列、4428164
        • Meir Medical Center
      • Ramat Gan、Central District、以色列、5262100
        • Sheba medical center
    • Southern District
      • Ashkelon、Southern District、以色列、7830604
        • Barzilai Medical Center
    • Tell Abīb
      • Tel Aviv、Tell Abīb、以色列、6423906
        • Sourasky Medical Center
    • Ḥeifā
      • Haifa、Ḥeifā、以色列、3109601
        • Rambam Health Care Campus
      • Haifa、Ḥeifā、以色列、3436212
        • Carmel Hospital
      • Haifa、Ḥeifā、以色列
        • Bnai Zion Medical Center
  • 俄罗斯
      • Petrozavodsk、俄罗斯、185019
        • Karelia Republican Hospital V.A. Baranova
      • Saratov、俄罗斯、410053
        • Regional Clinical Hospital of the Saratov Region
      • Yaroslavl、俄罗斯、150003
        • Research & Practice
    • Kursk Oblast
      • Kursk、Kursk Oblast、俄罗斯、305007
        • Kursk Regional Clinical Hospital
    • Leningradskaya Oblast'
      • Saint-Petersburg、Leningradskaya Oblast'、俄罗斯、194291
        • Gbuz Lokb
    • Moscow
      • Moscow、Moscow、俄罗斯、111123
        • Moscow Clinical Research Center
      • Moscow、Moscow、俄罗斯、115522
        • Federal State Budgetary Scientific Institution Research Institute Rheumatology named after V.A.Nasonova
      • Moscow、Moscow、俄罗斯、129110
        • M. F. Vladimirskiy Moscow Regional Research Clinical Institute
    • Moscow Oblast
      • Moscow、Moscow Oblast、俄罗斯、119991
        • First Moscow State Medical University I.M. Sechenov
    • Nizhny Novgorod Oblast
      • Nizhny Novgorod、Nizhny Novgorod Oblast、俄罗斯、603005
        • Nizhny Novgorod City Clinical Hospital Number 5
    • Ryazan Oblast
      • Ryazan、Ryazan Oblast、俄罗斯、390026
        • Ryazan Regional Clinical Cardiological Dispensary
    • Sankt-Peterburg
      • Saint Petersburg、Sankt-Peterburg、俄罗斯、191015
        • North-Western State Medical University named after I.I.Mechnikov
      • Saint Petersburg、Sankt-Peterburg、俄罗斯、190068
        • Clinical Rheumatology hospital #25
    • Tula Oblast
      • Tula、Tula Oblast、俄罗斯、300053
        • Tula Regional Clinical Hospital
    • Ulyanovsk Oblast
      • Ulyanovsk、Ulyanovsk Oblast、俄罗斯、432063
        • GUZ UOKB
  • 匈牙利
      • Debrecen、匈牙利、4032
        • Debreceni Egyetem Klinikai Kozpont
      • Debrecen、匈牙利、4031
        • Debreceni Egyetem - Kenézy Gyula Egyetemi Oktatókórház
    • Borsod-Abauj Zemplen county
      • Miskolc、Borsod-Abauj Zemplen county、匈牙利、3529
        • CRU Hungary Kft.
    • Pest County
      • Budapest、Pest County、匈牙利、1027
        • Revita Clinic
      • Budapest、Pest County、匈牙利、1033
        • Clinexpert Kft.
    • Veszprém City
      • Veszprém、Veszprém City、匈牙利、8200
        • Vital Medical Center
  • 南非
    • Eastern Cape
      • Port Elizabeth、Eastern Cape、南非、6045
        • Netcare Greenacres Hospital
    • Free State
      • Bloemfontein、Free State、南非、9301
        • Iatros International
      • Bloemfontein、Free State、南非、9301
        • FARMOVS
    • Gauteng
      • Kempton Park、Gauteng、南非、1619
        • Clinresco Centres
      • Pretoria、Gauteng、南非、0001
        • University of Pretoria - Faculty of Health Sciences
    • KwaZulu-Natal
      • Chatsworth、KwaZulu-Natal、南非、4092
        • Precise Clinical Solutions
      • Umhlanga、KwaZulu-Natal、南非、4320
        • Netcare Umhlanga Hospital
    • Western Cape
      • Cape Town、Western Cape、南非、7405
        • Arthritis Clinical Trial Centre
      • Stellenbosch、Western Cape、南非、7600
        • Winelands Medical Research Centre
  • 土耳其（türkiye）
      • Edirne、土耳其（türkiye）、22030
        • Trakya University
      • Istanbul、土耳其（türkiye）、34098
        • Istanbul University Cerrahpasa Medical School Internal Diseases Institute
      • Izmir、土耳其（türkiye）、35620
        • Izmir Katip Celebi Ataturk Egitim Arastirma Hastanesi
      • Konya、土耳其（türkiye）
        • Necmettin Erbakan Meram Medical Fac.
    • Eskişehir
      • Eskişehir、Eskişehir、土耳其（türkiye）、26480
        • Eskisehir Osmangazi University
    • Istanbul
      • Stanbul、Istanbul、土耳其（türkiye）、34899
        • Marmara Universitesi Pendik Egitim Arastirma Hastanesi
  • 奥地利
      • Vienna、奥地利、1100
        • Rheuma-Zentrum Oberlaa GmbH
    • State of Vienna
      • Vienna、State of Vienna、奥地利、1090
        • Medizinische Universität Wien
      • Vienna、State of Vienna、奥地利、1160
        • Wilhelminenspital
  • 希腊
    • Attikí
      • Chaïdári、Attikí、希腊、12462
        • Attikon General University Hospital
    • Kentrikí Makedonía
      • Thessaloniki、Kentrikí Makedonía、希腊、54642
        • Ippokrateio General Hospital of Thessaloniki
    • Évros
      • Alexandroupoli、Évros、希腊、68100
        • University Hospital of Alexandroupolis
  • 德国
      • Berlin、德国、14059
        • Schlosspark Klinik
      • Berlin、德国、12163
        • Praxis für Rheumatologie und Innere
      • Hamburg、德国、22391
        • Hamburger Rheuma Forschungszentrum I / Dres Raabe & Heintz
      • Hamburg、德国、20095
        • HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T
    • Hesse
      • Frankfurt am Main、Hesse、德国、60590
        • CIRI- Center of Innovative Diagnostics and Therapeutics Rheumatology/Immunology
    • Mecklenburg-Vorpommern
      • Bad Doberan、Mecklenburg-Vorpommern、德国、18209
        • Rheumazentrum Prof.Neeck MVZ
    • North Rhine-Westphalia
      • Cologne、North Rhine-Westphalia、德国、50937
        • Universitaetsklinikum Koeln
      • Ratingen、North Rhine-Westphalia、德国、40878
        • Rheumazentrum Ratingen Studienambulanz
    • Saxony-Anhalt
      • Magdeburg、Saxony-Anhalt、德国、39110
        • Institut für Präventive Medizin & Klinische Forschung GbR
  • 意大利
      • Florence、意大利、50141
        • Azienda Ospedaliera Universitaria Careggi
      • Naples、意大利、80131
        • University of Campania Luigi Vanvitelli
      • Verona、意大利、37100
        • Policlinico GB Rossi Borgo Roma
    • Abruzzo
      • Chieti、Abruzzo、意大利、66013
        • Clinical Research Center - Universita Degli Studi Gabriele d'Annunzio
    • Milano
      • Milan、Milano、意大利、20157
        • Ospedale Luigi Sacco
    • Tuscany
      • Siena、Tuscany、意大利、53100
        • Ospedale Le Scotte
  • 捷克语
      • Prague、捷克语、14000
        • Revmatologicka ambulance
      • Prague、捷克语、14800
        • Affidea Praha, s.r.o.
    • Brno-město
      • Brno、Brno-město、捷克语、63800
        • Revmatologie.s.r.o.
      • Brno、Brno-město、捷克语、61500
        • Revmacentrum MUDr. Mostera, s.r.o.
    • Moravian-Silesian Region
      • Ostrava、Moravian-Silesian Region、捷克语、722 00
        • Artroscan, s.r.o.
    • Ostrava Město
      • Ostrava、Ostrava Město、捷克语、70300
        • INREA s.r.o.
    • Pardubice Region
      • Pardubice、Pardubice Region、捷克语、53002
        • Arthrohelp S.R.O.
    • Praha 10
      • Prague、Praha 10、捷克语、100 00
        • CLINTRIAL s.r.o.
    • Praha 4
      • Prague、Praha 4、捷克语、140 00
        • Revmatologie MUDr. Štejfová
    • Praha, Hlavní Mešto
      • Prague、Praha, Hlavní Mešto、捷克语、12850
        • Revmatologicky Ustav
    • South Moravian
      • Brno、South Moravian、捷克语、61141
        • REVMACLINIC s.r.o.
    • Zlín
      • Uherské Hradiště、Zlín、捷克语、686 01
        • Medical Plus
      • Zlín、Zlín、捷克语、760 01
        • PV Medical Services s.r.o.
  • 斯洛伐克
    • Banská Bystrica Region
      • Zvolen、Banská Bystrica Region、斯洛伐克、960 01
        • Albamed s.r.o.
    • Bratislava Region
      • Bratislava、Bratislava Region、斯洛伐克、851 01
        • Romjan s.r.o.
    • Košice Region
      • Košice、Košice Region、斯洛伐克、040 11
        • Artromac n.o.
      • Spišská Nová Ves、Košice Region、斯洛伐克、05201
        • Reumed s.r.o.
    • Nitra Region
      • Topoľčany、Nitra Region、斯洛伐克、955 01
        • LERAM s.r.o.
    • Trenčín Region
      • Partizánske、Trenčín Region、斯洛伐克、958 01
        • Reumacentrum s.r.o.
  • 比利时
    • Bruxelles-Capitale, Région de
      • Brussels、Bruxelles-Capitale, Région de、比利时、1070
        • Université Libre de Bruxelles - Hôpital Erasme
    • Flanders
      • Merksem、Flanders、比利时、2170
        • ZNA Jan Palfijn
    • Limburg
      • Genk、Limburg、比利时、3600
        • Reuma Clinic, Locatie Jaarbeurslaan
  • 法国
      • Caluire-et-Cuire、法国、69300
        • Infirmerie Protestante de Lyon
      • Lille、法国、59037
        • Centre Hospitalier Régional Universitaire de Lille - Hôpital Roger Salengro
      • Paris、法国、75013
        • Pitie Salpetriere University Hospital
    • Alpes-Maritimes
      • Nice、Alpes-Maritimes、法国、06000
        • Chu De Nice
    • Alsace
      • Strasbourg、Alsace、法国、67098
        • CHU Strasbourg-Hautepierre
    • Aquitaine
      • Bordeaux、Aquitaine、法国、33076
        • Bordeaux University Hospital - Pellegrin
    • Auvergne-Rhône-Alpes
      • Lyon、Auvergne-Rhône-Alpes、法国、69003
        • Hôpital Edouard Herriot
    • Centre-Val de Loire
      • Orléans、Centre-Val de Loire、法国、45067
        • Centre Hospitalier Régional d'Orléans
    • Haute-Garonne
      • Toulouse、Haute-Garonne、法国、31059
        • Hôpital Pierre-Paul Riquet
    • Loire-Atlantique
      • Nantes、Loire-Atlantique、法国、44093
        • Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
    • Meurthe-et-Moselle
      • Vandœuvre-lès-Nancy、Meurthe-et-Moselle、法国、54511
        • Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois
    • Vendée
      • La Roche-sur-Yon、Vendée、法国、85000
        • CHD Vendée
  • 波兰
    • Greater Poland Voivodeship
      • Poznan、Greater Poland Voivodeship、波兰、61-113
        • Ai Centrum Medyczne Sp. Z O.O.
      • Poznan、Greater Poland Voivodeship、波兰、61-397
        • Prywatna Praktyka Lekarska Prof. UM dr hab. med. Pawel Hrycaj
    • Kuyavian-Pomeranian Voivodeship
      • Bydgoszcz、Kuyavian-Pomeranian Voivodeship、波兰、85-168
        • Szpital Uniwersytecki Nr 2 w Bydgoszczy, Klinika Reumatologii i Ukladowych Chorób Tkanki Lacznej
      • Torun、Kuyavian-Pomeranian Voivodeship、波兰、87-100
        • MICS Centrum Medyczne Toruń
    • Lublin Voivodeship
      • Tomaszów Lubelski、Lublin Voivodeship、波兰、22-600
        • Samodzielny Publiczny Zespol Opieki Zdrowotnej W Tomaszowie Lubelskim
    • Lubusz Voivodeship
      • Nowa Sól、Lubusz Voivodeship、波兰、67-100
        • Twoja Przychodnia Centrum Medyczne Nowa Sol
    • Masovian Voivodeship
      • Nadarzyn、Masovian Voivodeship、波兰、05-830
        • NZOZ Lecznica MAK-MED s.c.
      • Warsaw、Masovian Voivodeship、波兰、02-677
        • ETG Warszawa
      • Warsaw、Masovian Voivodeship、波兰、02-665
        • Centrum Medyczne Reuma Park
      • Warsaw、Masovian Voivodeship、波兰、00-874
        • Medycyna Kliniczna
      • Warsaw、Masovian Voivodeship、波兰、02-118
        • Rheuma Medicus- Zaklad Opieki Zdrowotnej
      • Warsaw、Masovian Voivodeship、波兰、03-291
        • Centrum Medyczne AMED Warszawa Targówek
    • Podlaskie Voivodeship
      • Bialystok、Podlaskie Voivodeship、波兰、15-351
        • Osteo Medic sc A. Racewicz, J. Supronik
    • Pomeranian Voivodeship
      • Gdansk、Pomeranian Voivodeship、波兰、80-546
        • Centrum Badan Klinicznych PI-House sp. z o.o.
    • Silesian Voivodeship
      • Bytom、Silesian Voivodeship、波兰、41-902
        • BIF-MED
      • Katowice、Silesian Voivodeship、波兰、40-081
        • Centrum Medyczne Pratia Katowice
      • Ustroń、Silesian Voivodeship、波兰、43-450
        • Slaskie Centrum Reumatologii, Rehabilitacji I Zapobiegania Niepelnosprawnosci Im. Gen.J.Zietka
    • Warmian-Masurian Voivodeship
      • Elblag、Warmian-Masurian Voivodeship、波兰、82-300
        • Ambulatorium Barbara Bazela
  • 波多黎各
      • Caguas、波多黎各、00725
        • Centro Reumatologico Caguas
      • Ponce、波多黎各、00716
        • Ponce Medical School Foundation Inc.
      • San Juan、波多黎各、00918
        • Mindful Medical Research
      • San Juan、波多黎各、00909
        • Latin Clinical Trial Center
      • San Juan、波多黎各、00917
        • GCM Medical Group, PSC - Hato Rey Site
  • 澳大利亚
    • New South Wales
      • Botany、New South Wales、澳大利亚、2019
        • Optimus Clinical Research
      • Newcastle、New South Wales、澳大利亚、2292
        • Genesis Research Services
    • Queensland
      • Maroochydore、Queensland、澳大利亚、4558
        • Rheumatology Research Unit
    • Tasmania
      • Hobart、Tasmania、澳大利亚、7000
        • Southern Clinical Research
    • Victoria
      • Camberwell、Victoria、澳大利亚、3124
        • Emeritus Research
  • 瑞士
      • Fribourg、瑞士、1708
        • HFR Fribourg - Hôpital Cantonal
    • Canton of Basel-City
      • Basel、Canton of Basel-City、瑞士、4056
        • University Hospital Basel
    • Canton of St. Gallen
      • Sankt Gallen、Canton of St. Gallen、瑞士、9007
        • Cantonal Hospital St.Gallen
  • 立陶宛
      • Vilnius、立陶宛、01117
        • Centro poliklinika
    • Kauno Miestas
      • Kaunas、Kauno Miestas、立陶宛、45130
        • Republican Hospital of Kaunas
    • Šiauliai County
      • Šiauliai、Šiauliai County、立陶宛、76231
        • Respublikin Šiauli ligonin
  • 罗马尼亚
      • Brăila、罗马尼亚、810019
        • CMI Cristei Dorica
    • Brașov County
      • Brasov、Brașov County、罗马尼亚、500283
        • C.M.D.T.A. Neomed
    • Bucharest
      • Bucharest、Bucharest、罗马尼亚、011172
        • Spital Clinic Sf. Maria
      • Bucharest、Bucharest、罗马尼亚、014142
        • Delta Health Care
      • Bucharest、Bucharest、罗马尼亚、30463
        • CCBR Clinical Research
    • Galați County
      • Galati、Galați County、罗马尼亚、800578
        • Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei
    • Iaşi
      • Iași、Iaşi、罗马尼亚、707027
        • RK Medcenter
    • Maramureş
      • Baia Mare、Maramureş、罗马尼亚、430031
        • Spitalul Judeean de Urgen Dr. Constantin Opri Baia Mare
    • Vâlcea County
      • Râmnicu Vâlcea、Vâlcea County、罗马尼亚、240762
        • SC Medaudio-Optica SRL
  • 美国
    • Arizona
      • Flagstaff、Arizona、美国、86001
        • Arizona Arthritis & Rheumatology Research, PLLC
      • Gilbert、Arizona、美国、85234
        • Arthrocare, Arthritiscare & Research PC
      • Glendale、Arizona、美国、85306
        • Arizona Arthritis & Rheumatology Research, PLLC
      • Mesa、Arizona、美国、85210
        • Arizona Arthritis & Rheumatology Research, PLLC
      • Peoria、Arizona、美国、85381
        • HOPE Research Institute
      • Phoenix、Arizona、美国、85018
        • HOPE Research Institute
      • Tucson、Arizona、美国、85704
        • Arizona Arthritis & Rheumatology Research, PLLC
    • California
      • Covina、California、美国、91722
        • Medvin Clinical Research - Covina
      • Fullerton、California、美国、92835
        • St Joseph Heritage Healthcare
      • Huntington Beach、California、美国、92648
        • Christine Thai, MD
      • Irvine、California、美国、92604
        • Private Practice - Dr. Christine J. Leehealey
      • Rancho Mirage、California、美国、92270
        • Desert Medical Advances
      • San Diego、California、美国、92128
        • Rheumatology Center of San Diego
      • San Leandro、California、美国、94578
        • East Bay Rheumatology Medical Group, Inc
      • Tujunga、California、美国、91042
        • Dan La, MD Inc
      • Tustin、California、美国、92780
        • Robin K. Dore MD, Inc
      • Upland、California、美国、91786
        • Inland Rheumatology & Osteoporosis Medical Group
      • Van Nuys、California、美国、91405
        • Medvin Clinical Research - Weidmann
      • Whittier、California、美国、90602
        • Medvin Clinical Research - Whittier
    • Connecticut
      • Stamford、Connecticut、美国、06905
        • Stamford Therapeutics Consortium
    • Florida
      • Boca Raton、Florida、美国、33486
        • Rheumatology Associates of South Florida
      • Miami、Florida、美国、33165
        • New Horizon Research Center
      • Miami、Florida、美国、33135
        • Suncoast Research Group
      • New Port Richey、Florida、美国、34652
        • Suncoast Clinical Research, Inc.
      • Plantation、Florida、美国、33324
        • IRIS Research and Development, LLC
      • South Miami、Florida、美国、33143
        • Qps-Mra, Llc
      • Tampa、Florida、美国、33613
        • ForCare Clinical Research
    • Georgia
      • Atlanta、Georgia、美国、30342
        • Arthritis & Rheumatology of Georgia
      • Gainesville、Georgia、美国、30501
        • Arthritis Center of North Georgia
    • Idaho
      • Boise、Idaho、美国、83702
        • St. Luke's Intermountain Research Center
    • Illinois
      • Chicago、Illinois、美国、60640
        • Great Lakes Clinical Trials
    • Indiana
      • Evansville、Indiana、美国、47715
        • Qualmedica Research, LLC
    • Kansas
      • Wichita、Kansas、美国、67205
        • Alliance for Multispecialty Research, LLC
    • Kentucky
      • Elizabethtown、Kentucky、美国、42701
        • Center For Arthritis and Osteoporosis
    • Louisiana
      • Lake Charles、Louisiana、美国、70605
        • Accurate Clinical Research
    • Maryland
      • Wheaton、Maryland、美国、20902
        • The Center For Rheumatology And Bone Research
    • Massachusetts
      • Fall River、Massachusetts、美国、02721
        • NECCR PrimaCare Research
    • Michigan
      • Brighton、Michigan、美国、48116
        • University of Michigan
      • Grand Rapids、Michigan、美国、49546
        • West Michigan Rheumatology
      • Okemos、Michigan、美国、48864
        • Advanced Rheumatology, PC
    • Missouri
      • City of Saint Peters、Missouri、美国、63303
        • StudyMetrix Research
      • Springfield、Missouri、美国、65807
        • Clinvest Research LLC
    • Montana
      • Kalispell、Montana、美国、59901
        • Glacier View Research Institute
    • Nebraska
      • Lincoln、Nebraska、美国、68516
        • Physician Research Collaboration, LLC
      • Omaha、Nebraska、美国、68114
        • Westroads Clinical Research, Inc.
    • Nevada
      • Reno、Nevada、美国、89519
        • Allied Clinical Research
    • New Hampshire
      • Lebanon、New Hampshire、美国、03756
        • Dartmouth-Hitchcock Medical Center
    • New Mexico
      • Albuquerque、New Mexico、美国、87102
        • Albuquerque Clinical Trials, Inc.
      • Albuquerque、New Mexico、美国、87102
        • Albuquerque Center For Rheumatology
      • Santa Fe、New Mexico、美国、87505
        • Santa Fe Rheumatology
    • North Carolina
      • Charlotte、North Carolina、美国、28211
        • Accellacare - Charlotte
      • Durham、North Carolina、美国、27704
        • M3-Emerging Medical Research, LLC
      • Hickory、North Carolina、美国、28602
        • Piedmont Rheumatology, P.A.
      • Leland、North Carolina、美国、28451
        • Cape Fear Arthritis Care
      • Salisbury、North Carolina、美国、28144
        • PMG Research of Salisbury
      • Wilmington、North Carolina、美国、28401
        • PMG Research of Wilmington, LLC
    • Ohio
      • Cincinnati、Ohio、美国、45242
        • Cincinnati Rheumatic Disease Study Group
      • Marietta、Ohio、美国、45750
        • Marietta Memorial Hospital
      • Middleburg Heights、Ohio、美国、44130
        • Paramount Medical Research & Consulting, LLC
    • Oklahoma
      • Oklahoma City、Oklahoma、美国、73104
        • Oklahoma Medical Research Foundation
      • Oklahoma City、Oklahoma、美国、73103
        • Health Research of Oklahoma
    • Pennsylvania
      • Bethlehem、Pennsylvania、美国、18015
        • East Penn Rheumatology Associates
      • Duncansville、Pennsylvania、美国、16635
        • Altoona Center for Clinical Research
      • Wyomissing、Pennsylvania、美国、19610
        • Clinical Research Center of Reading,LLC
      • Wyomissing、Pennsylvania、美国、19610
        • Pennsylvania Regional Center for Arthritis and Osteoporosis Research
    • South Dakota
      • Rapid City、South Dakota、美国、57701
        • Regional Health Clinical Research
    • Texas
      • Baytown、Texas、美国、77521
        • Accurate Clinical Management
      • College Station、Texas、美国、77845
        • Arthritis & Osteoporosis Clinic of Brazos Valley
      • Houston、Texas、美国、77043
        • Biopharma Informatic, LLC
      • Houston、Texas、美国、77089
        • Accurate Clinical Research
      • Houston、Texas、美国、77084
        • Accurate Clinical Management - Houston
      • Houston、Texas、美国、77089
        • Research Physicians Network, LLC
      • League City、Texas、美国、77573
        • Accurate Clinical Research
      • San Antonio、Texas、美国、78229
        • Accurate Clinical Research, Inc.
      • San Antonio、Texas、美国、78229
        • Clinical Trials of Texas, Inc.
      • Sugar Land、Texas、美国、77479
        • Accurate Clinical Management
      • Tomball、Texas、美国、77375
        • Dynamed Clinical Research, LP d/b/a DM Clinical Research
      • Tomball、Texas、美国、77377
        • DM Clinical Research/Rheumatology Clinic of Houston
    • Washington
      • Spokane、Washington、美国、99204
        • Arthritis Northwest, PLLC
      • Vancouver、Washington、美国、98664
        • The Vancouver Clinic
    • West Virginia
      • Charleston、West Virginia、美国、25304
        • CAMC Health Education and Research Institute Inc
  • 英国
      • Liverpool、英国、L9 7AL
        • Aintree University Hospital NHS Foundation Trust
      • Wolverhampton、英国、WV10 0QP
        • New Cross Hospital
    • Bournemouth
      • Christchurch、Bournemouth、英国、BH23 2JX
        • Christchurch Hospital
    • Devon
      • Plymouth、Devon、英国、Pl6 8DH
        • Derriford Hospital
      • Torquay、Devon、英国、TQ2 7AA
        • Torbay Hospital
    • England
      • Dudley、England、英国、DY1 2HQ
        • The Dudley Group NHS Foundation Trust
      • London、England、英国、NW32QG
        • Royal Free London NHS Foundation Trust
      • Truro、England、英国、TR1 3LJ
        • The Royal Cornwall Hospital
    • Essex
      • Chelmsford、Essex、英国、CM1 7ET
        • Mid Essex Hospital Services NHS Trust
    • Hampshire
      • Portsmouth、Hampshire、英国、PO6 3LY
        • Queen Alexandra Hospital
    • Kingston Upon Hull
      • Hull、Kingston Upon Hull、英国、HU3 2JZ
        • Hull and East Yorkshire Hospitals NHS Trust
    • North Tyneside
      • Newcastle upon Tyne、North Tyneside、英国、NE29 8NH
        • Northumbria Healthcare NHS Foundation Trust
    • Nottinghamshire
      • Sutton in Ashfield、Nottinghamshire、英国、NG17 4JL
        • King's Mill Hospital
    • Waltham Forest
      • London、Waltham Forest、英国、E11 1NR
        • Barts Health NHS Trust - Whipps Cross University Hospital
  • 荷兰
    • Limburg
      • Born、Limburg、荷兰、6121 XK
        • PT&R / PreCare Trial & Recruitment
    • Provincie Friesland
      • Leeuwarden、Provincie Friesland、荷兰、8934 AD
        • Medische Centrum Leeuwarden
  • 西班牙
      • Córdoba、西班牙、14004
        • Hospital Quirónsalud Córdoba
      • Córdoba、西班牙、14004
        • HU Reina Sofia
      • Madrid、西班牙、28041
        • Hospital Universitario 12 de Octubre
      • Madrid、西班牙、28046
        • Hospital Universitario La Paz
      • Seville、西班牙、41009
        • Hospital Universitario Virgen Macarena
      • Seville、西班牙、41010
        • Hospital Quiron Infanta Luisa
    • A Coruña [La Coruña]
      • A Coruña、A Coruña [La Coruña]、西班牙、15006
        • Complejo Hospitalario Universitario A Coruña
      • Santiago de Compostela、A Coruña [La Coruña]、西班牙、15702
        • Clínica Gaias - Santiago
    • Alicante
      • Elche、Alicante、西班牙、03202
        • Hospital General Universitario de Elche
      • Villajoyosa、Alicante、西班牙、03570
        • Hospital Marina Baixa
    • Basque Country
      • Bilbao、Basque Country、西班牙、48013
        • Osi Bilbao-Basurto
    • Catalunya [Cataluña]
      • Barcelona、Catalunya [Cataluña]、西班牙、08036
        • Hospital Clinic de Barcelona
      • Barcelona、Catalunya [Cataluña]、西班牙、08022
        • Clinica Sagrada Familia
      • Barcelona、Catalunya [Cataluña]、西班牙、08023
        • Hospital Quirón Barcelona
      • Sabadell、Catalunya [Cataluña]、西班牙、08208
        • Corporacio Sanitaria Parc Tauli
      • Sant Joan Despí、Catalunya [Cataluña]、西班牙、08970
        • Consorci Sanitari Integral. Hospital Moisés Broggi, Sant Joan Despí
    • Galicia [Galicia]
      • Santiago de Compostela、Galicia [Galicia]、西班牙、15706
        • CHUS - Hospital Clinico Universitario
    • Madrid, Comunidad de
      • Fuenlabrada、Madrid, Comunidad de、西班牙、28944
        • Hospital Universitario de Fuenlabrada
      • Getafe、Madrid, Comunidad de、西班牙、28905
        • Hospital Universitario Getafe
      • Majadahonda、Madrid, Comunidad de、西班牙、28222
        • Hospital Universitario Puerta de Hierro Majadahonda
    • Pontevedra [Pontevedra]
      • Vigo、Pontevedra [Pontevedra]、西班牙、36200
        • CHUVI- Hospital do Meixoeiro

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年 及以上 (成人、年长者)

接受健康志愿者

不

描述

纳入标准：

  • 参与者必须至少具有以下特征之一：

    • 在本研究之前记录的 VTE 证据
    • 至少60岁
    • 体重指数 (BMI) 大于或等于 30 公斤每平方米 (kg/m²)，或
    • 50 岁至 60 岁以下且 BMI 25 至 30 公斤/平方米以下。
  • 参与者必须对至少一种缓解疾病的抗风湿药 (DMARD)（合成的或生物的）反应不足或不耐受。

排除标准：

  • 参与者没有理由不服用 TNF 抑制剂。
  • 参与者不得怀孕或哺乳。
  • 参与者不得有超过一次的 VTE。
  • 参与者不得患有癌症。
  • 参与者不得患有活动性带状疱疹、严重感染、活动性肺结核或任何其他严重疾病。
  • 参与者不得在研究开始后的四个星期内接种过活疫苗。
  • 参与者在研究开始后的四个星期内不得参加任何其他临床试验。
  • 参与者在过去一年中不得有静脉吸毒史、其他非法药物滥用史或长期酗酒史。

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：治疗
  • 分配：随机化
  • 介入模型：并行分配
  • 屏蔽：无（打开标签）

武器和干预

参与者组/臂
干预/治疗
实验性的：Baricitinib 2mg
Participants received 2 milligrams (mg) of baricitinib once daily until the planned number of adjudicated primary endpoint events occurred or until the data monitoring committee (DMC) recommended early termination. Those with inadequate response at 1-year after start of treatment with baricitinib 2mg could receive rescue treatment with baricitinib 4mg.
药品：巴瑞克替尼
口服给药。
其他名称：
  • LY3009104
实验性的：Baricitinib 4mg
Participants received 4 mg of baricitinib once daily until the planned number of adjudicated primary endpoint events occurred or until the DMC recommended early termination.
药品：巴瑞克替尼
口服给药。
其他名称：
  • LY3009104
有源比较器：Tumor Necrosis Factor (TNF) Inhibitor
Participants received a TNF inhibitor (adalimumab or etanercept) administered according to approved local labeling until the planned number of adjudicated primary endpoint events occurred or until the DMC recommended early termination.
药品：TNF Inhibitor
Administered subcutaneously.
其他名称：
  • 依那西普
  • 阿达木单抗

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Pooled JAJA and JAJD: Time From First Dose of Study Treatment to First Event of Venous Thromboembolism (VTE) [Combined Baricitinib Dose Versus TNF Inhibitor]
大体时间：From the first dose of study treatment up to 30 days after the last dose or the last study visit, whichever occurs first (approximately up to 6.1 years for JAJA and 5.3 years for JAJD participants)
Time from first dose of study treatment to first event of VTE was evaluated using hazard ratio as the measure of treatment effect, estimated from Cox proportional hazards regression model. The analysis was based on pooled data from studies JAJA (NCT03915964) and JAJD (NCT04086745) and was stratified by study, with treatment group and randomization stratification factors (VTE history, age/Body Mass Index (BMI) combination, prior inadequate response or intolerance to a TNF inhibitor, and geographic region) as explanatory variables.
From the first dose of study treatment up to 30 days after the last dose or the last study visit, whichever occurs first (approximately up to 6.1 years for JAJA and 5.3 years for JAJD participants)

次要结果测量

结果测量
措施说明
大体时间
Pooled JAJA and JAJD: Time From First Dose of Study Treatment to First Event of Venous Thromboembolism (VTE) [Individual Baricitinib Dose Versus TNF Inhibitor]
大体时间：From the first dose of study treatment up to 30 days after the last dose or the last study visit, whichever occurs first (approximately up to 6.1 years for JAJA and 5.3 years for JAJD participants)
Time from first dose of study treatment to first event of VTE was evaluated using hazard ratio as the measure of treatment effect, estimated from Cox proportional hazards regression model. The analysis was based on pooled data from studies JAJA (NCT03915964) and JAJD (NCT04086745) and was stratified by study, with treatment group and randomization stratification factors (VTE history, age/Body Mass Index (BMI) combination, prior inadequate response or intolerance to a TNF inhibitor, and geographic region) as explanatory variables.
From the first dose of study treatment up to 30 days after the last dose or the last study visit, whichever occurs first (approximately up to 6.1 years for JAJA and 5.3 years for JAJD participants)
Pooled JAJA and JAJD: Time From First Dose of Study Treatment to First Arterial Thromboembolic Event (ATE) [Combined and Individual Baricitinib Dose Versus TNF Inhibitor]
大体时间：From the first dose of study treatment up to 30 days after the last dose or the last study visit, whichever occurs first (approximately up to 6.1 years for JAJA and 5.3 years for JAJD participants)
Time from first dose of study treatment to first ATE was evaluated using hazard ratio as the measure of treatment effect, estimated from Cox proportional hazards regression model. The analysis was based on pooled data from studies JAJA (NCT03915964) and JAJD (NCT04086745) and was stratified by study, with treatment group and randomization stratification factors (VTE history, age/BMI combination, prior inadequate response or intolerance to a TNF inhibitor, and geographic region) as explanatory variables.
From the first dose of study treatment up to 30 days after the last dose or the last study visit, whichever occurs first (approximately up to 6.1 years for JAJA and 5.3 years for JAJD participants)
Pooled JAJA and JAJD: Time From First Dose of Study Treatment to First Major Adverse Cerebro-Cardiovascular Event (MACE) [Combined and Individual Baricitinib Dose Versus TNF Inhibitor]
大体时间：From the first dose of study treatment up to 30 days after the last dose or the last study visit, whichever occurs first (approximately up to 6.1 years for JAJA and 5.3 years for JAJD participants)
Time from first dose of study treatment to first MACE was evaluated using hazard ratio as the measure of treatment effect, estimated from Cox proportional hazards regression model. The analysis was based on pooled data from studies JAJA (NCT03915964) and JAJD (NCT04086745) and was stratified by study, with treatment group and randomization stratification factors (VTE history, age/BMI combination, prior inadequate response or intolerance to a TNF inhibitor, and geographic region) as explanatory variables.
From the first dose of study treatment up to 30 days after the last dose or the last study visit, whichever occurs first (approximately up to 6.1 years for JAJA and 5.3 years for JAJD participants)
Pooled JAJA and JAJD: Time From First Dose of Study Treatment to First Malignancy (Excluding Nonmelanoma Skin Cancer [NMSC]) [Combined and Individual Baricitinib Dose Versus TNF Inhibitor]
大体时间：From the first dose of study treatment up to 30 days after the last dose or the last study visit, whichever occurs first (approximately up to 6.1 years for JAJA and 5.3 years for JAJD participants)
Time from first dose of study treatment to first malignancy (excluding NMSC) was evaluated using hazard ratio as the measure of treatment effect, estimated from Cox proportional hazards regression model. The analysis was based on pooled data from studies JAJA (NCT03915964) and JAJD (NCT04086745) and was stratified by study, with treatment group and randomization stratification factors (VTE history, age/BMI combination, prior inadequate response or intolerance to a TNF inhibitor, and geographic region) as explanatory variables.
From the first dose of study treatment up to 30 days after the last dose or the last study visit, whichever occurs first (approximately up to 6.1 years for JAJA and 5.3 years for JAJD participants)
Pooled JAJA and JAJD: Time From First Dose of Study Treatment to First Opportunistic Infection [Combined and Individual Baricitinib Dose Versus TNF Inhibitor]
大体时间：From the first dose of study treatment up to 30 days after the last dose or the last study visit, whichever occurs first (approximately up to 6.1 years for JAJA and 5.3 years for JAJD participants)
Time from first dose of study treatment to first opportunistic infection was evaluated using hazard ratio as the measure of treatment effect, estimated from Cox proportional hazards regression model. The analysis was based on pooled data from studies JAJA (NCT03915964) and JAJD (NCT04086745) and was stratified by study, with treatment group and randomization stratification factors (VTE history, age/BMI combination, prior inadequate response or intolerance to a TNF inhibitor, and geographic region) as explanatory variables.
From the first dose of study treatment up to 30 days after the last dose or the last study visit, whichever occurs first (approximately up to 6.1 years for JAJA and 5.3 years for JAJD participants)
Pooled JAJA and JAJD: Time From First Dose of Study Treatment to First Serious Infection [Combined and Individual Baricitinib Dose Versus TNF Inhibitor]
大体时间：From the first dose of study treatment up to 30 days after the last dose or the last study visit, whichever occurs first (approximately up to 6.1 years for JAJA and 5.3 years for JAJD participants)
Time from first dose of study treatment to first serious infection was evaluated using hazard ratio as the measure of treatment effect, estimated from Cox proportional hazards regression model. The analysis was based on pooled data from studies JAJA (NCT03915964) and JAJD (NCT04086745) and was stratified by study, with treatment group and randomization stratification factors (VTE history, age/BMI combination, prior inadequate response or intolerance to a TNF inhibitor, and geographic region) as explanatory variables.
From the first dose of study treatment up to 30 days after the last dose or the last study visit, whichever occurs first (approximately up to 6.1 years for JAJA and 5.3 years for JAJD participants)

其他结果措施

结果测量
措施说明
大体时间
Total Duration of Treatment Exposure for Combined Baricitinib Dose, Individual Baricitinib Dose and TNF Inhibitor
大体时间：From the date of first dose of study drug up to the last dose (approximately up to 6.1 years)

Duration of exposure was calculated as:

  • Baricitinib 2mg exposure = date of last baricitinib 2mg treatment - date of first baricitinib 2mg dose + 1. For participants who were rescued from baricitinib 2 mg to 4 mg, their drug exposure after rescue was censored and not counted as exposure to baricitinib 2mg.
  • Baricitinib 4mg exposure = date of last baricitinib 4mg treatment - date of first baricitinib 4mg dose + 1.
  • TNF inhibitor exposure = date of last TNFi (adalimumab or etanercept) - date of first TNFi dose (adalimumab or etanercept) + 1, regardless of treatment cycling from adalimumab to etanercept or vice versa.
  • Total baricitinib exposure (2/4 mg) = date of last baricitinib (2mg or 4mg) treatment - date of first baricitinib (2mg or 4mg) dose + 1, regardless of rescue from baricitinib 2mg to baricitinib 4mg.

Patient-years is calculated as sum of duration of exposure in days for all patients in dosing regimen divided by 365.25.
From the date of first dose of study drug up to the last dose (approximately up to 6.1 years)

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Eli Lilly and Company

合作者

Incyte Corporation

调查人员

  • 研究主任：Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)、Eli Lilly and Company

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

有用的网址

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2019年4月25日

初级完成 (实际的)

2025年5月28日

研究完成 (实际的)

2025年5月28日

研究注册日期

首次提交

2019年4月12日

首先提交符合 QC 标准的

2019年4月12日

首次发布 (实际的)

2019年4月16日

研究记录更新

最后更新发布 (实际的)

2026年6月24日

上次提交的符合 QC 标准的更新

2026年5月27日

最后验证

2026年5月1日

更多信息

与本研究相关的术语

其他相关的 MeSH 术语

其他研究编号

  • 17172
  • I4V-MC-JAJA (其他标识符：Eli Lilly and Company)
  • 2018-003351-37 (EudraCT编号)
  • 2023-508022-10-00 (克蒂斯)

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

是的

IPD 计划说明

在批准研究计划和签署数据共享协议后，将在安全访问环境中提供匿名的个人患者级别数据。

IPD 共享时间框架

在美国和欧盟研究的适应症首次公布和批准后 6 个月（以较晚者为准）可提供数据。 数据将无限期地可供请求。

IPD 共享访问标准

研究计划必须得到独立审查小组的批准，研究人员必须签署数据共享协议。

IPD 共享支持信息类型

  • 研究方案
  • 树液
  • 企业社会责任

药物和器械信息、研究文件

研究美国 FDA 监管的药品

是的

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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