Platelet Rich Fibrin and Concentrated Growth Factors on Osseointegration of Immediate Implants
A Comparative Study Between the Effect of Platelet-rich Fibrin and Concentrated Growth Factors on Osseointegration of Immediate Implants (a Randomized Clinical Trial)
This study will involve 14 patients with mandibular premolars indicated for extraction and immediate replacement. The patients will be randomly allocated into two groups and each patient will receive one implant. In Group A, a CGF membrane will be laid in the implant cavity. While in Group B, a PRF membrane will be laid in the implant cavity. Bone graft material will be applied to fill the empty parts of the socket.
Resonance frequency measurement will be done using the OSTELL device intraoperatively, at the 1st week and after 3 months. Cone-beam computed tomography will be done preoperatively, immediately following surgery, and after 3 months
研究概览
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Alexandria、埃及
- Alexandria Faculty of Dentistry
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Cooperative patients with good oral hygiene.
- Patients having a history of mandibular premolars indicated for extraction and immediate replacement.
Exclusion Criteria:
- Heavy smokers.
- Parafunctional occlusal habits.
- Uncontrolled diabetes.
- History of chemotherapy or radiotherapy.
- Hematological disorders that prevent either implantation or centrifugation.
- Pregnancy.
- The nee¬d for additional augmentation or previous augmentation of the same region.
- Chronic periapical pathology
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：单身的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：A组
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Concentrated Growth Factors membrane will be laid in the implant cavity.
Bone graft material will be applied to fill the empty parts of the socket.
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有源比较器：B组
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Platelet-Rich Fibrin (PRF) membrane will be laid in the implant cavity.
Bone graft material will be applied to fill the empty parts of the socket.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Change in implant stability
大体时间：immediately, at 1 week, at 3 months
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Osstell instrument (Integration Diagnostics, Goteborg, Sweden) with Smartpeg™ (Integration Diagnostics, Goteborg, Sweden), a transducer suitable for implants will be used to assess stability of implants by RFA.
ISQ (implant stability quotient) will be obtained from the measurement results.
During measurement, the Smartpeg™ will be placed over the location of implant prosthesis and the Osstell probe will be approximated to it from the buccal, palatal, mesial and distal aspects of the implant giving four ISQ values.
A mean ISQ for each implant is then calculated by averaging the four values.
The ISQ values of the implants will be measured during the operation, at the first week and three months after the operation.
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immediately, at 1 week, at 3 months
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Change in Bone density
大体时间：immediately, after 3 months
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The Patients will be asked to do CBCT immediately after surgery and after 3 months
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immediately, after 3 months
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Change in bone formation
大体时间：immediately, after 3 months
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Amount of bone formed buccal and lingual to the implant will be assessed using CBCT
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immediately, after 3 months
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Marginal bone loss
大体时间：after 3 months
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it will be assessed using CBCT
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after 3 months
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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