- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00024180
FR901228 in Treating Patients With Hematologic Cancer
A Phase I Study of Depsipeptide in Selected Hematologic Malignancies (NSC 630176)
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
PURPOSE: Phase I trial to study the effectiveness of FR901228 in treating patients who have hematologic cancer.
Study Overview
Detailed Description
OBJECTIVES:
- Determine the in vivo biologic effect of FR901228 (depsipeptide) in patients with chronic lymphocytic leukemia, small lymphocytic lymphoma, acute myeloid leukemia, or acute lymphoblastic leukemia.
- Determine the pharmacokinetics and cellular pharmacodynamics of this drug in these patients.
- Determine any preliminary anti-tumor activity of this drug in these patients.
OUTLINE: This is a dose-decreasing, multicenter study. Patients are stratified according to disease (chronic lymphocytic leukemia and small lymphocytic lymphoma vs acute myeloid leukemia and acute lymphoblastic leukemia).
Patients receive FR901228 (depsipeptide) IV over 4 hours on days 1, 8, and 15. Treatment repeats every 4 weeks for up to 1 year in the absence of disease progression or unacceptable toxicity.
Cohorts of 10 patients per stratum receive decreasing doses of FR901228 until the minimal active dose is determined. If 5 or more patients show clinical or biological response, the subsequent cohort is treated at a lower dose. If fewer than 5 patients respond, the subsequent cohort is treated at a higher dose.
PROJECTED ACCRUAL: A minimum of 20 patients (10 per stratum) will be accrued for this study.
Study Type
Phase
- Phase 1
Contacts and Locations
Study Locations
-
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Ohio
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Columbus, Ohio, United States, 43210-1240
- Arthur G. James Cancer Hospital - Ohio State University
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
DISEASE CHARACTERISTICS:
Diagnosis of one of the following hematologic malignancies:
- Chronic lymphocytic leukemia (CLL)
- Small lymphocytic lymphoma (SLL) (including Waldenstrom's macroglobulinemia)
- Acute myeloid leukemia (AML)
- Acute lymphoblastic leukemia (ALL)
Stratum I (CLL and SLL):
- Received at least one prior therapy containing a purine analog OR
- Received another form of therapy (including alkylating agents) due to history of severe autoimmune disease, requirement for chronic corticosteroid, or other contraindication to purine analog therapy
Stratum II (AML and ALL):
- Primary refractory or relapsed leukemia within the past year that is not amenable to curative therapy
- OR
Untreated or previously treated poor-risk leukemia defined by any of the following:
- 65 years of age and over
- Poor-risk candidates for aggressive chemotherapy
- Poor-risk cytogenetics (for AML, karyotype abnormalities other than t(8;21), inv(16), t(15;17))
PATIENT CHARACTERISTICS:
Age:
- 18 and over
Performance status:
- ECOG 0-2
Life expectancy:
- At least 12 weeks
Hematopoietic:
Stratum I only:
- No uncontrolled autoimmune hemolytic anemia
- No idiopathic thrombocytopenic purpura
Stratum II only:
- WBC no greater than 10,000/mm^3 OR
- WBC no greater than 40,000/mm^3 that is stable for at least 1 week (may be sustained by hydroxyurea through the first week of study)
Hepatic:
- Bilirubin no greater than 1.5 mg/dL
- ALT and AST no greater than 3 times upper limit of normal
Renal:
- Creatinine less than 2.0 mg/dL
Cardiovascular:
- Ejection fraction at least 50% by MUGA
- No myocardial infarction or unstable angina within the past 6 months
- No prior unstable ventricular or supraventricular cardiac arrhythmias
Other:
- HIV negative
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No other medical or psychiatric problem that would preclude study
Stratum I only:
- No active infection requiring oral or IV antibiotics
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Not specified
Chemotherapy:
- See Disease Characteristics
- At least 28 days since prior chemotherapy (except hydroxyurea)
- At least 6 weeks since prior nitrosoureas
- At least 8 weeks since prior UCN-01 (unless plasma UCN-01 level less than 1 uM)
Endocrine therapy:
- See Disease Characteristics
Radiotherapy:
- At least 28 days since prior radiotherapy
Surgery:
- At least 28 days since prior major surgery
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
Collaborators and Investigators
Collaborators
Investigators
- Study Chair: Guido Marcucci, MD, Ohio State University Comprehensive Cancer Center
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- CDR0000068898
- OSU-00H0350
- NCI-27
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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