St. John's Wort Versus Placebo in Social Phobia

The purpose of this study is to determine the effectiveness of St. John's Wort as compared to placebo (an inactive substance) in the treatment of outpatients with social phobia.

Study Overview

• Status: Completed
• Conditions: Phobic Disorders
• Intervention / Treatment: Drug: St. John's Wort

Detailed Description

Social Phobia is a prevalent and debilitating condition, with a lifetime prevalence rate to be 13.3 percent. Socially phobic patients have been found to be functionally impaired in the areas of education, employment and social relationships, to have poorer quality of life, and increased suicidal ideation and psychiatric comorbidity. Double-blind studies have found benzodiazepines, selective and non-selective MAOI inhibitors, several SSRIs, and the anticonvulsants pregabalin and gabapentin to be effective. However, side effects with these compounds suggests the need for better tolerated compounds, e.g., in the paroxetine multi-center trial (the only drug with an FDA approved indication), 27 percent reported somnolence, 26 percent nausea, and 37 percent of males reported delayed ejaculation; 34 percent of patients discontinued the trial early. There has been considerable worldwide interest in St. John's Wort (SJW) (Hypericum perforatum) as a treatment of mild to moderate depression. There have been 23 randomized trials suggesting SJW is more effective than placebo for the treatment of outpatients with mild to moderate depression. SJW is very well tolerated with mild side effects observed in only 2.5 percent of cases in a large (3250 patients) drug monitoring study. Pharmacokinetic studies have found Hypericum to have affinity for serotonin, dopamine and GABA alpha and GABA beta receptors, each of which have been implicated in social phobia, thus there is a suggestion that SJW may be effective for this disorder.

This will be a 12-week, double blind, placebo-controlled trial, designed to generate effect size data that will be used to determine sample size needed to power a definitive study. Forty patients will be randomized to either SJW (LI 160) or matching placebo. This will be a flexible-dose design, starting at 300 mg tid to a maximum of 1800 mg total per day. An intent-to-treat analysis will be employed. Subjects will be evaluated weekly for two weeks, then bi-weekly thereafter. The primary outcome measure will be the change from baseline to endpoint on the Liebowitz Social Anxiety Scale.

• Study Type: Interventional
• Enrollment: 40
• Phase: Phase 2

Contacts and Locations

Study Locations

• United States
  • Wisconsin
    • Madison, Wisconsin, United States, 53562
      • The Dean Foundation for Health, Research, and Education

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Female patients: at least 2 years post-menopausal, surgically sterile, or practicing a medically acceptable method of contraception.
• Meets DSM-IV criteria for Social Phobia, generalized subtype, lasting 12 months in duration (phone screening will determine)

Exclusion Criteria:

• Primary diagnosis of major depression, dysthymia, panic disorder, schizophrenia, schizo-affective disorder, bipolar disorder, or PTSD
• Substance abuse or dependence in the past 6 months
• Vascular dementia or primary degenerative dementia of the Alzheimer's type
• Treatment with MAOIs, TCAs, SSRIs, venlafaxine, nefazodone, remeron, citalopram, or bupropion within 14 days of first visit.
• Fluoxetine within 14 days of first visit.
• Failure to respond to at least two adequate antidepressant trials for social anxiety.
• Investigational drugs within 30 days of baseline
• Known allergy or hypersensitivity to St. John's Wort
• Currently in behavior therapy for Social Phobia

ALL INQUIRIES WILL UNDERGO A PHONE SCREENING TO DETERMINE WHETHER THEY MEET ELIGIBLITY REQUIREMENTS.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Collaborators and Investigators

• Sponsor: National Center for Complementary and Integrative Health (NCCIH)
• Investigators: Principal Investigator: Kenneth Kobak, PhD, Dean Foundation for Health, Research and Analysis; Principal Investigator: Leslie Taylor, MD, Dean Foundation for Health, Research and Analysis

Publications and helpful links

Helpful Links

• A non-profit foundation located in Middleton, Wisconsin, conducting clinical trials of psychiatric and medical therapies.

Study record dates

Study Major Dates

• Study Start: December 1, 2001
• Study Completion: August 1, 2004

Study Registration Dates

• First Submitted: May 3, 2002
• First Submitted That Met QC Criteria: May 3, 2002
• First Posted (Estimate): May 6, 2002

Study Record Updates

• Last Update Posted (Estimate): August 18, 2006
• Last Update Submitted That Met QC Criteria: August 17, 2006
• Last Verified: July 1, 2006

More Information

Terms related to this study

• Keywords: Anxiety; Mental health; Social phobia; Psychiatric; Wisconsin; Social anxiety; St. John' Wort
• Additional Relevant MeSH Terms: Mental Disorders; Anxiety Disorders; Phobia, Social; Phobic Disorders
• Other Study ID Numbers: R21AT000502-01A1 (U.S. NIH Grant/Contract)