Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid

Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid: A Comparison of Clinical Efficacy

Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma. A chemical peel involves applying the peeling agent to the skin for a short period. The skin will peel similar to a sunburn, and moisturizers are applied to the skin. Although both agents are well-accepted, there have been no good comparisons of the two agents. The purpose of this study is determine if there is a difference in the effectiveness of these two agents.

Study Overview

• Status: Completed
• Conditions: Melasma
• Intervention / Treatment: Procedure: Jessner's solution chemical peel; Procedure: Trichloroacetic acid chemical peel

• Study Type: Interventional
• Enrollment (Actual): 19
• Phase: Phase 4

Contacts and Locations

Study Locations

• United States
  • Georgia
    • Atlanta, Georgia, United States, 30322
      • Emory University Dermatology Clinic

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Adults > 18 years old
• Clinical diagnosis of melasma
• Mental capacity to give informed consent

Exclusion Criteria:

• Pregnancy
• H/o allergy to Jessner's solution, tricholoracetetic acid, tretinoin, or hydroquinone
• Active dermatitis
• Presence of cutaneous infection

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: NON_RANDOMIZED
• Interventional Model: SINGLE_GROUP
• Masking: NONE

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
ACTIVE_COMPARATOR: Chemical Peel; Split face treatment paradigm	Procedure: Jessner's solution chemical peel; Procedure: Trichloroacetic acid chemical peel

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Clinical efficacy by clinician's evaluation	Hyperpigmenation Global Score	3 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Efficacy by subject's evaluation	Hyperpigmentation Global Score	3 months

Collaborators and Investigators

• Sponsor: Emory University
• Investigators: Principal Investigator: Carl Washington, MD, Emory University Department of Dermatology

Study record dates

Study Major Dates

• Study Start: January 1, 2008
• Primary Completion (ACTUAL): January 1, 2010
• Study Completion (ACTUAL): November 1, 2013

Study Registration Dates

• First Submitted: September 13, 2005
• First Submitted That Met QC Criteria: September 13, 2005
• First Posted (ESTIMATE): September 14, 2005

Study Record Updates

• Last Update Posted (ESTIMATE): November 14, 2013
• Last Update Submitted That Met QC Criteria: November 12, 2013
• Last Verified: November 1, 2013

More Information

Terms related to this study

• Keywords: Melasma; Jessner's solution; Trichloroacetic acid (TCA)
• Additional Relevant MeSH Terms: Skin Diseases; Hyperpigmentation; Pigmentation Disorders; Melanosis
• Other Study ID Numbers: IRB00024850