- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00176345
Impact of Exercise Training on Endothelial Function in CAD
Impact of Exercise Training on Bradykinin-Mediated Endothelial Function in Patients With Coronary Artery Disease
Bradykinin has been identified to contribute to the release of nitric oxide (NO), prostacyclin, and EDHF through activation of specific bradykinin 2 (B2) receptors, which is finally promoting a vasodilatory respone. Regular physical exercise training results in an improvement of endothelial function in patients with CAD. These positive effects were partially attributed to an increased expression of endothelial NO synthase (eNOS) and cyclooxygenase (COX) as a result of the training intervention.
Aim of this trial is therefore to determine, whether the training-induced correction of endothelial dysfunction is also bradykinin-dependent.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
A total of 20 patients with stable coronary artery disease are prospectively randomized to 4 weeks of exercise training or sedentary lifestyle.
Endothelial function of the radial artery is determined by a high-resolution A-mode ultrasound.
Study Type
Enrollment
Phase
- Phase 2
Contacts and Locations
Study Contact
- Name: Rainer P Hambrecht, MD
- Phone Number: 1428 ++49-341 865
- Email: hamr@medizin.uni-leipzig.de
Study Contact Backup
- Name: Sandra Erbs, MD
- Phone Number: 1428 ++49-341 865
- Email: Sandra.Erbs@medizin.uni-leipzig.de
Study Locations
-
-
Saxony
-
Leipzig, Saxony, Germany, 04289
- Recruiting
- University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology
-
Contact:
- Rainer P Hambrecht, MD
- Phone Number: 1428 ++49-341-865
- Email: hamr@medizin.uni-leipzig.de
-
Contact:
- Sandra Erbs, MD
- Phone Number: 1428 ++49-341-865
- Email: Sandra.Erbs@medizin.uni-leipzig.de
-
Principal Investigator:
- Rainer P Hambrecht, MD
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- stable CAD
- male gender
Exclusion Criteria:
- insulin-dependent diabetes mellitus
- significant valvular heart disease
- smoking
- exercise-induced myocardial ischemia
- conditions prohibiting exercise training
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Educational/Counseling/Training
- Allocation: Randomized
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
Endothelial function
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Rainer P Hambrecht, MD, University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology
Study record dates
Study Major Dates
Study Start
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 639/97
- 157/02
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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