- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00314223
Identification of Gene Polymorphism in Patients With Sick Sinus Syndrome in Chinese Population in Taiwan
Background: Sinus node dysfunction is a major cause of bradycardia necessitating pacemaker implantation. Evidences of genetic study supported that some genes involved in the pacemaker current or renin-angiotensin system were related to sinus node dysfunction. However, the influence of gene polymorphisms on sinus node dysfunction was not well studied.
Methods: A group of 100 patients with documented sinus node dysfunction and 100 age- and sex- matched healthy control patients will be enrolled into this study. Gene polymorphism study includes the angiotensin-I converting enzyme gene, angiotensin II type 1 receptor gene, HCN1-4, SCN5A, KCNE and other possible gene polymorphisms which are related to sinus node function based on previous reports. Genetic polymorphisms are identified with polymerase chain reaction-based restriction analysis. Comparison of multiple haplotype analysis and single-locus analysis will be analyzed between the cases and controls.
Estimated Results: Some genetic polymorphisms of these genes which are related to sinus node function or rennin-angiotensin system will show association with sinus node dysfunction. In multilocus haplotype analysis, some genetic haplotype profiles may demonstrate significant difference between cases and controls. In single locus analysis, some genetic polymorphisms may be associated with sinus node dysfunction.
Estimated Conclusion and Clinical Implication: This study will demonstrate the genetic polymorphisms in RAS genes or some other genes associated with sinus node dysfunction. These results will support the roles of these genetic polymorphisms in determining the risk of sinus node dysfunction among the Chinese population in Taiwan.
Study Overview
Status
Conditions
Study Type
Enrollment
Contacts and Locations
Study Contact
- Name: Jan-Yow Chen, MD
- Phone Number: 886-4-22052121
- Email: janyow@ms77.hinet.net
Study Locations
-
-
-
Taichung, Taiwan
- Recruiting
- China Medical University Hospital
-
Contact:
- Cheng-Chieh. Lin, MD
- Phone Number: 886-4-22052121
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Heart rate was less than 40/min or long pause more than 3 seconds in series EKG or 24-hour EKG.
- Sinus nodal recovery time exceeds 1600 ms in cardiac electrophysiology study.
Exclusion Criteria:
- Severe systemic disease.
- Acute coronary syndrome.
- Bradycardia with reversible cause.
Study Plan
How is the study designed?
Design Details
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- DMR94-IRB-167
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Sinus Arrhythmia
-
Taipei Medical University WanFang HospitalUnknownAsystole | Sinus Bradycardia | Sinus Arrhythmia | Sinus Tachycardia | Atril FibrillationTaiwan
-
National Heart, Lung, and Blood Institute (NHLBI)CompletedHeart Diseases | Cardiovascular Diseases | Heart Failure | Arrhythmia | Heart Failure, Congestive | Sinus Arrhythmia
-
Medtronic BRCMedtronicCompletedAtrial Fibrillation | Sinus ArrhythmiaItaly
-
Ceryx Medical AustraliaAvaniaNot yet recruitingHeart Failure With Reduced Ejection FractionNew Zealand
-
Ceryx Medical LtdCardiff and Vale University Health BoardNot yet recruitingHeart Failure With Reduced Ejection FractionUnited Kingdom
-
Tulane UniversityNational Institute of Mental Health (NIMH); National Institutes of Health (NIH)WithdrawnSelf-regulation | Respiratory Sinus ArrhythmiaUnited States
-
Medtronic Bakken Research CenterCompletedHeart Failure | Heart Block | Arrhythmia | Sinus Node DiseaseBelgium, Russian Federation, Former Serbia and Montenegro, India, Kuwait, Saudi Arabia
-
Medtronic Cardiac Rhythm and Heart FailureCompletedAtrial Fibrillation | Bradycardia | Arrhythmia | Atrioventricular Block | Sick Sinus SyndromeFrance, United States, Australia
-
Medtronic Cardiac Rhythm and Heart FailureCompleted
-
Abbott Medical DevicesCompleted