- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00394537
Labetalol to Prevent Hypertension and Tachycardia During Fiberoptic Bronchoscopy
Passing a bronchoscope through the airways frequently causes a stress response even though patients are sedated. This stress response is usually an increase in pulse and blood pressure, which may have undesirable effects on the heart and circulation.
We plan to give patients labetalol (a beta blocker which reduces pulse and blood pressure) in addition to normal sedation, to patients undergoing bronchoscopy in our department.
Study Overview
Study Type
Enrollment (Anticipated)
Phase
- Phase 4
Contacts and Locations
Study Locations
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-
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Petach Tikva, Israel, 49100
- Rabin Medical Center
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- All patients over 18 years old undergo fiberoptic bronchoscopy in our unit
Exclusion Criteria:
- inability or refusal to give informed consent
- bronchoscopy through an artificial airway
- intolerance or allergy to the study drug
- bradycardia (HR<60/min) or hypotension (systolic BP <100) at screening
- pregnancy,
- concomitant treatment with diltiazem or verapamil
- intention to use propofol as the sedative agent for bronchoscopy.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
Heart Rate
|
Systolic Blood Pressure
|
Diastolic Blood Pressure
|
Rate pressure product (HR*SBP/100)
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Mordechai Kramer, MD, Rabin Medical Center
Publications and helpful links
Study record dates
Study Major Dates
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Physiological Effects of Drugs
- Adrenergic beta-Antagonists
- Adrenergic Antagonists
- Adrenergic Agents
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Antihypertensive Agents
- Autonomic Agents
- Peripheral Nervous System Agents
- Sympathomimetics
- Adrenergic alpha-1 Receptor Antagonists
- Adrenergic alpha-Antagonists
- Labetalol
Other Study ID Numbers
- 3997
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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