- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00460044
ADMA and Mechanical Ventilation in Preterm Infants
April 12, 2007 updated by: Amsterdam UMC, location VUmc
Plasma ADMA Concentrations at Birth and Mechanical Ventilation in Preterm Infants
The purpose of this study is to study the relation between mechanical ventilation and ADMA concentrations at birth.
Study Overview
Status
Completed
Conditions
Detailed Description
Nitric oxide (NO) plays an important role in the normal development and maturation of the lungs.
In addition, NO is an important mediator of vascular smooth muscle relaxation, ventilation perfusion matching, neurotransmission and host defence and bacteriostasis.
Asymmetric dimethylarginine (ADMA) is an endogenous derivative of arginine that inhibits NOS and thereby the bioavailability of NO.
Preterm infants have increased concentrations of ADMA.
Therefore, inhibition of NO by increased concentrations of ADMA which could be associated with reduced pulmonary functioning.
Study Type
Observational
Enrollment
35
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
No older than 7 months (Child)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Gestational age < 32 weeks
- Birth weight < 1500 gram
- Written informed consent of parents
Exclusion Criteria:
- Congenital abnormalities
- Chromosomal abnormalities
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Director: R M van Elburg, MD, PhD, Amsterdam UMC, location VUmc
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2002
Study Completion (Actual)
July 1, 2003
Study Registration Dates
First Submitted
April 11, 2007
First Submitted That Met QC Criteria
April 12, 2007
First Posted (Estimate)
April 13, 2007
Study Record Updates
Last Update Posted (Estimate)
April 13, 2007
Last Update Submitted That Met QC Criteria
April 12, 2007
Last Verified
April 1, 2007
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- HK0607
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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