- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00532519
Effectiveness of the Selective Serotonin Reuptake Inhibitor,Citalopram (Cipralex), in Prurigo Nodularis
Prurigo nodularis (PN) is a common dermatological disorder, manifested as scaly nodules which appear mainly on the extensor surfaces of the limbs. PN may appear secondarily to skin scratching in chronic hepatitis, liver cirrhosis, uremia, hypothyroidism etc. Nevertheless, in many cases no underlying physical disease is present. According to the literature, in fifty percent of the patients there is co-morbidity with depression, anxiety or somatoform disorders.
We hypothesize that a group of these patients may benefit from antidepressant therapy.
Study Overview
Study Type
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Liran Horev, MD
- Phone Number: OO97226777111
- Email: LIRAN_CH@BEZEQINT.NET
Study Locations
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Jerusalem, Israel
- : Hadassah Medical Organization,
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Contact:
- Hadas Lemberg, PhD
- Phone Number: 00 972 2 6777572
- Email: : lhadas@hadassah.org.il
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- prurigo nodularis
- age: 18-70 years
- agreed to participate
Exclusion Criteria:
- younger than 18 or older than 70
- pregnant or lactating women
- chronic diseases: cancer, neurological disorders, diseases that are known to be associated with pruritus such as liver cirrhosis, uremia, etc.
- sensitivity to cipralotam
- psychosis, bi-polar disorder, substance addiction, use of antidepressant in the previous year
- use of systemic therapies to prurigo nodularis such as thalidomide, cyclosporine
Study Plan
How is the study designed?
Design Details
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: liran horev, md, Hadassah Medical Organization
Study record dates
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ESTIMATE)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Skin Diseases
- Dermatitis
- Skin Diseases, Eczematous
- Prurigo
- Neurodermatitis
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Psychotropic Drugs
- Serotonin Uptake Inhibitors
- Neurotransmitter Uptake Inhibitors
- Membrane Transport Modulators
- Serotonin Agents
- Antidepressive Agents
- Antidepressive Agents, Second-Generation
- Citalopram
Other Study ID Numbers
- horcoop-hmo-ctil
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