Evaluating a Web-Based Ventilator Management Educational Program for Clinicians (The Lung Injury Knowledge Network [LINK] Study) (LINK)

Improving Ventilator Management and Preventing Injury to Patients With Acute Respiratory Failure

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a severe lung condition that causes respiratory failure. Individuals with ALI/ARDS often require the use of a respirator or artificial breathing machine, known as a mechanical ventilator, while in an intensive care unit (ICU). Research has shown that lung protective ventilation (LPV), a type of mechanical ventilation technique, is an effective way to reduce the number of deaths due to ALI/ARDS. This study will evaluate the effectiveness of a Web-based educational program that aims to educate ICU clinicians about the use of LPV in patients with ALI/ARDS.

Study Overview

• Status: Unknown
• Conditions: Respiratory Distress Syndrome, Adult
• Intervention / Treatment: Behavioral: Web-Based Educational Program

Detailed Description

ALI/ARDS is a life-threatening condition that involves inflammation of the lungs and fluid accumulation in the air sacs, leading to low blood oxygen levels and respiratory failure. Common causes include pneumonia, septic shock, and lung trauma, and most patients require immediate care in an ICU. The main form of treatment for ALI/ARDS is the delivery of oxygen and a continuous level of pressure to the damaged lungs through mechanical ventilation. Each year, 74,500 people die due to ALI/ARDS and 22% of these deaths could be prevented with the use of LPV. LPV is a mechanical ventilation technique in which lower volumes of oxygen are administered. The purpose of this study is to implement and evaluate a Web-based educational program that will provide educational and instructional resources about ALI/ARDS and LPV to ICU clinicians, including physicians, nurses, and respiratory therapists.

Hospitals participating in this study will be randomly assigned to access the Web site at either the beginning of the study period or a later time. Participating clinicians at each hospital will access the Web site as often as necessary for a 6-month period. The Web site will contain background and educational information on ALI/ARDS and LPV, including how to recognize ALI/ARDS and how to implement LPV in patients. Scholarly articles and other materials, including a chart to help clinicians determine appropriate ventilator settings for each patient, will be available to download. Clinicians will also be able to email questions to critical care experts. At the end of the 6-month study period, study staff will compare the number of patients receiving LPV to the number of patients who received LPV prior to the start of the study.

• Study Type: Interventional
• Enrollment (Anticipated): 120
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Canada
  • Ontario
    • Toronto, Ontario, Canada, M4N3M5
      • University of Toronto, Sunnybrook Health Sciences

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria for Hospitals:

• Between 10 and 20 ICU beds with 5 to 10 ALI/ARDS patients cared for each month
• Provide critical care services
• Keep electronic medical records on ICU patients
• ICU staff must have access to computers with Intranet or Internet

Inclusion Criteria for Clinicians:

• Provide care for mechanically ventilated patients in ICUs
• Willing to participate by viewing Web site

Exclusion Criteria for Hospitals:

• Cardiac, cardiothoracic, neurosurgical, neonatal, or pediatric ICUs
• Residents and fellows must provide care to majority of critically ill patients
• Fewer than 5 to 10 ALI/ARDS patients cared for each month

Study Plan

How is the study designed?

Design Details

• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Early Intervention Group	Behavioral: Web-Based Educational Program; Participating clinicians at each hospital will access the Web site as often as necessary for a 6-month period. The Web site will contain background and educational information on ALI/ARDS and LPV, including how to recognize ALI/ARDS and how to implement LPV in patients. Scholarly articles and other materials, including a chart to help clinicians determine appropriate ventilator settings for each patient, will be available to download. Clinicians will also be able to email questions to critical care experts.
Active Comparator: Delayed Intervention Group	Behavioral: Web-Based Educational Program; Participating clinicians at each hospital will access the Web site as often as necessary for a 6-month period. The Web site will contain background and educational information on ALI/ARDS and LPV, including how to recognize ALI/ARDS and how to implement LPV in patients. Scholarly articles and other materials, including a chart to help clinicians determine appropriate ventilator settings for each patient, will be available to download. Clinicians will also be able to email questions to critical care experts.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Percentage of eligible patients with ALI/ARDS who are receiving LPV	Measured at Month 6

Collaborators and Investigators

• Sponsor: Sunnybrook Health Sciences Centre
• Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
• Investigators: Principal Investigator: Gordon D. Rubenfeld, MD, University of Toronto, Sunnybrook Health Sciences

Study record dates

Study Major Dates

• Study Start: February 1, 2009
• Primary Completion (Anticipated): September 1, 2013
• Study Completion (Anticipated): July 1, 2014

Study Registration Dates

• First Submitted: October 10, 2007
• First Submitted That Met QC Criteria: October 10, 2007
• First Posted (Estimate): October 11, 2007

Study Record Updates

• Last Update Posted (Estimate): July 11, 2013
• Last Update Submitted That Met QC Criteria: July 9, 2013
• Last Verified: August 1, 2010

More Information

Terms related to this study

• Keywords: Acute Respiratory Distress Syndrome; Acute Lung Injury; Acute Respiratory Failure; Web-Based Intervention; Lung Preventive Ventilation
• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Respiration Disorders; Lung Diseases; Wounds and Injuries; Infant, Newborn, Diseases; Infant, Premature, Diseases; Thoracic Injuries; Respiratory Distress Syndrome; Respiratory Distress Syndrome, Newborn; Acute Lung Injury; Lung Injury
• Other Study ID Numbers: 518; R01HL067939 (U.S. NIH Grant/Contract); GC1# A19846