Pharmacology and Physiology of the Lower Urinary Tract

June 19, 2008 updated by: University College London Hospitals

The function of the lower urinary tract is simple - urine storage and voiding. However, despite this simplicity of function, the control of the lower urinary tract is a rather complex, multilevel process (urothelium, detrusor, peripheral nerves, spinal cord and higher cerebral centres) and the mechanisms involved remain poorly elucidated.

This study is designed to gain a more in depth understanding of the lower urinary tract function. Using bladder biopsies, tissue staining for characteristic markers present on nerves and other cells will be performed. We hypothesize that certain markers are altered in disease and turn back towards the control level of healthy people or patients with successful medical treatment.

Study Overview

Status

Unknown

Conditions

Study Type

Observational

Enrollment (Anticipated)

200

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Thomas M Kessler, MD
  • Phone Number: 8713 44-207-829-8713
  • Email: tkessler@gmx.ch

Study Contact Backup

Study Locations

  • United Kingdom
      • London, United Kingdom, WC1N 3BG
        • Recruiting
        • Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery
        • Contact:
          • Thomas M Kessler, MD
          • Phone Number: 8713 44-207-829-8713
          • Email: tkessler@gmx.ch
        • Contact:
        • Principal Investigator:
          • Clare J Fowler, FRCP

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Patients with lower urinary tract dysfunction and controls with normal lower urinary tract function

Description

Inclusion Criteria:

  • Patients with lower urinary tract dysfunction
  • Controls with normal lower urinary tract function

Exclusion Criteria:

  • Age < 18 years old
  • Pregnancy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
1
Patients with lower urinary tract dysfunction
2
Controls with normal lower urinary tract function

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Immunohistochemistry + PCR of bladder tissue
Time Frame: not specified (storage of biopsies)
not specified (storage of biopsies)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University College London Hospitals

Investigators

  • Principal Investigator: Clare J Fowler, FRCP, Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK
  • Principal Investigator: Suzy Elneil, PhD, MRCOG, Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

February 1, 2002

Primary Completion (Anticipated)

December 1, 2008

Study Completion (Anticipated)

December 1, 2008

Study Registration Dates

First Submitted

April 16, 2008

First Submitted That Met QC Criteria

April 17, 2008

First Posted (Estimate)

April 21, 2008

Study Record Updates

Last Update Posted (Estimate)

June 20, 2008

Last Update Submitted That Met QC Criteria

June 19, 2008

Last Verified

June 1, 2008

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 00/0039

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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