A Study of MK0140 in Diabetic Patients With Macular Edema (0140-001)

October 30, 2015 updated by: Merck Sharp & Dohme LLC

A Phase IIb, Randomized, Masked, Sham-Controlled, Clinical Trial to Study the Efficacy and Safety of the Helical Triamcinolone Acetonide Implant (MK0140) in Diabetic Patients With Clinically Significant Macular Edema

This study will evaluate the treatment effect of three doses of the I-vation TA implant (MK0140) in diabetic patients with clinically significant macular edema.

Study Overview

Status

Terminated

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

2

Phase

  • Phase 2

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Patient has clinically significant macular edema as a result of their diabetes (Type I or Type 2)
  • Patient has in the study eye, 20/40 - 20/160 vision
  • Patient has Type 1 or Type 2 diabetes
  • Patient agrees to remain abstinent or use (or have their partner use) 2 acceptable methods of birth control

Exclusion Criteria:

  • Patient has had any active ocular infection in either eye
  • Patient has intraocular pressure > 22 mmHg or a diagnosis of glaucoma
  • Patient has cystoid macular edema in the study eye
  • Patient has a history of elevated IOP in response to ocular steroid therapy in either eye
  • Patient has had intraocular surgery in the study eye within 6 months prior to Visit 1
  • Patient has an HbAIc value > 10% at Visit 1
  • Patient has within the last 4 months initiated intensive insulin treatment or plan to do so in the next 4 months
  • Patient has a history of cancer within 5 years prior to signing informed consent
  • Patient has clinically-relevant chronic renal failure
  • Patient has high blood pressure
  • Patient has coronary heart disease
  • Patient has known allergies to steroids

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: 1
100 mcg triamcinolone acetonide
Drug: triamcinolone acetonide
100 mcg; 500 mcg; 925 mcg triamcinolone acetonide on helical coil implant to elute over 12 months.
Other Names:
  • MK0140
Experimental: 2
500 mcg triamcinolone acetonide
Drug: triamcinolone acetonide
100 mcg; 500 mcg; 925 mcg triamcinolone acetonide on helical coil implant to elute over 12 months.
Other Names:
  • MK0140
Experimental: 3
925 mcg triamcinolone acetonide
Drug: triamcinolone acetonide
100 mcg; 500 mcg; 925 mcg triamcinolone acetonide on helical coil implant to elute over 12 months.
Other Names:
  • MK0140
No Intervention: 4
sham control - not implanted, no medication

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Change from baseline in OCT retinal thickness; evaluate the safety and tolerability of doses.
Time Frame: After 12 months of therapy.
After 12 months of therapy.

Secondary Outcome Measures

Outcome Measure
Time Frame
Evaluation of visual acuity; change from baseline in OCT center-point retinal thickness; the need for focal/grid laser photocoagulation during the study; the progression of diabetic retinopathy
Time Frame: After 12 months of therapy.
After 12 months of therapy.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Merck Sharp & Dohme LLC

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

June 1, 2008

Primary Completion (Actual)

November 1, 2008

Study Completion (Actual)

November 1, 2008

Study Registration Dates

First Submitted

June 4, 2008

First Submitted That Met QC Criteria

June 4, 2008

First Posted (Estimate)

June 6, 2008

Study Record Updates

Last Update Posted (Estimate)

November 1, 2015

Last Update Submitted That Met QC Criteria

October 30, 2015

Last Verified

October 1, 2015

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 0140-001
  • MK0140-001
  • 2008_521

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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