Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment

Our aim is to evaluate the potential of a new laboratory method that measure sperm capacitation to predict fertilization of oocytes in patients that undergo IVF treatments

Study Overview

• Status: Unknown
• Conditions: Sperm Capacitation
• Intervention / Treatment: Biological: sperm capacitation; Other: biologic; Other: sperm capacitation

Detailed Description

Capacitation is a physiologic process in which the sperm acquire the potential to fertilize oocytes. Capacitation can be measured, but the available technics are expensive, inaccurate and complex. A new method to evaluate sperm capacitation was developed in Bar Ilan University, Israel. We intend to measure the capacitation of semen that is used for fertilizing human oocytes in patients treated at the IVF unit at Assaf Harofeh Medical Center.By this, to evaluate the potential of the new method to predict human oocyte fertilization.If the method will be found valuable, it will enable to develop new drugs/methods that may improve sperm capacitation and by this to improve oocyte fertilization leading to more embryos, pregnancies and deliveries.

• Study Type: Observational
• Enrollment (Anticipated): 50

Contacts and Locations

• Study Contact: Name: arieh raziel, prof; Phone Number: 97289779005; Email: araziel@asaf.health.gov.il
• Study Contact Backup: Name: raphael ron-el, prof; Phone Number: 97289779005; Email: rronel@asaf.health.gov.il

Study Locations

• Israel
  • Zerifin
    • Beer Yaacov, Zerifin, Israel, 70300
      • Recruiting
      • Assaf Harofeh Mc
      • Contact: arieh raziel, prof; Phone Number: 97289779005; Email: araziel@asaf.health.gov.il
      • Contact: raphael ron-el, prof; Phone Number: 97289779005; Email: rronel@asaf.health.gov.il
      • Principal Investigator: arieh raziel, prof
      • Sub-Investigator: raphael ron-el, prof

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients requiring IVF within the "routine" work of an IVF Unit

Description

Inclusion Criteria:

• Patients requiring IVF within the "routine" work of an IVF Unit
• normo-responding woman
• non ICSI cycles

Exclusion Criteria:

• Patients undergoing ICSI only cycle
• Low responders-less than 8 oocytes
• Male patients with low semen volume

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
A; Sperm capacitation: Sperm capacitation is measured in a sample of the same ejaculated sperm unit given for fertilizing human oocytes in an IVF treatment cycle	Biological: sperm capacitation; sperm capacitation measured at Bar Ilan University; Other: biologic; sperm synthesis of G-actine to F-actine; Other Names: sperm capacitation; Other: sperm capacitation; sperm synthesis of G-actine to F-actine; Other Names: sperm synthesis of G-actine to F-actine

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Fertilization rate of human oocytes in thr "routine" IVF Laboratory work	One year

Collaborators and Investigators

• Sponsor: Assaf-Harofeh Medical Center

Study record dates

Study Major Dates

• Study Start: July 1, 2008
• Primary Completion (ANTICIPATED): January 1, 2009
• Study Completion (ANTICIPATED): July 1, 2009

Study Registration Dates

• First Submitted: August 7, 2008
• First Submitted That Met QC Criteria: August 7, 2008
• First Posted (ESTIMATE): August 8, 2008

Study Record Updates

• Last Update Posted (ESTIMATE): August 8, 2008
• Last Update Submitted That Met QC Criteria: August 7, 2008
• Last Verified: July 1, 2008

More Information

Terms related to this study

• Other Study ID Numbers: 54/08