- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06172504
Ejaculation Frequency and Semen Parameters (EFASP)
Effect of Male Ejaculation Frequency on Semen Parameters
The goal of this observational study is to determine whether the frequency of ejaculation in men had an effect on semen parameters.. The main questions it aims to answer are:
- question 1:Whether the frequency of ejaculation has an effect on semen parameters
- question 2:Whether the penultimate abstinence period has an effect on semen parameters
The participants were men who underwent semen examination in the andrology clinic of the Reproductive Center of the First Hospital of Jilin University. A brief medical history was collected from each volunteer, including demographic information, fertility history and as well as information regarding their general health.The focus of the investigation is the time of abstinence for this examination, the penultimate abstinence period, and the number of ejaculation since the last 1 month.
Study Overview
Detailed Description
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: yang yu, doctor
- Phone Number: +86 13844000361
- Email: yuyang0351@jlu.edu.cn
Study Locations
-
-
Jilin
-
Changchun, Jilin, China, 130000
- Recruiting
- The First Hospital of Jilin University
-
Contact:
- yang yu, doctor
- Phone Number: +86 13844000361
- Email: yuyang0351@jlu.edu.cn
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Normal ejaculation function, normal sexual life, masturbation can ejaculate
- Male age between 22 and 45 years old.
- According to World Health Organization standards, the semen examination time is within 48h to 7 days of abstinence.
Exclusion Criteria:
- The man was diagnosed with extremely severe oligospermia (sperm concentration <1 million/ml) and azoospermia.
- Identify the factors affecting semen parameters, long-term exposure to high temperature, long-term exposure to chemicals, heavy metals, radiation and other toxic and harmful substances, orchitis/epididymitis, cryptorchidism, radiotherapy and chemotherapy treatment, and taking drugs to improve sperm within three months
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Effect of ejaculation frequency on sperm DNA fragmentation rate
Time Frame: 6 months
|
The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm DNA fragment rate.
Survey the basic information of the subjects and their frequency of ejaculation in the past month.The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) >12 times/month.
The outcome was to compare whether there were differences in semen parameters between the groups
|
6 months
|
Effect of ejaculation frequency on sperm motility rate
Time Frame: 6 months
|
The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm motility rate.
Survey the basic information of the subjects and their frequency of ejaculation in the past month.
The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) >12 times/month.
The outcome was to compare whether there were differences in semen parameters between the groups
|
6 months
|
Effect of ejaculation frequency on total sperm count
Time Frame: 6 months
|
The subjects abstained for 3-7 days and masturbated to collect semen for measurement of total sperm count.
Survey the basic information of the subjects and their frequency of ejaculation in the past month.
The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) >12 times/month.
The outcome was to compare whether there were differences in semen parameters between the groups
|
6 months
|
Effect of ejaculation frequency on sperm vitality rate
Time Frame: 6 months
|
The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm vitality rate.
Survey the basic information of the subjects and their frequency of ejaculation in the past month.
The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) >12 times/month.
The outcome was to compare whether there were differences in semen parameters between the groups
|
6 months
|
Effect of ejaculation frequency on sperm morphology
Time Frame: 6 months
|
The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm morphology.
Survey the basic information of the subjects and their frequency of ejaculation in the past month.
The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) >12 times/month.
The outcome was to compare whether there were differences in semen parameters between the groups
|
6 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Effect of the penultimate abstinence period on DNA fragmentation rate
Time Frame: 6 months
|
The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm morphology.
Survey the basic information of the subjects and their penultimate abstinence period.
The outcome was to compare whether the penultimate abstinence period had an effect on DNA fragmentation rate(the cutoff value is 15%).
We plans to recruit more than 1000 subjects.
|
6 months
|
Collaborators and Investigators
Investigators
- Principal Investigator: yang yu, The First Hospital of Jilin University
Publications and helpful links
General Publications
- Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, de Mouzon J, Sokol R, Rienzi L, Sunde A, Schmidt L, Cooke ID, Simpson JL, van der Poel S. The International Glossary on Infertility and Fertility Care, 2017. Fertil Steril. 2017 Sep;108(3):393-406. doi: 10.1016/j.fertnstert.2017.06.005. Epub 2017 Jul 29.
- Vander Borght M, Wyns C. Fertility and infertility: Definition and epidemiology. Clin Biochem. 2018 Dec;62:2-10. doi: 10.1016/j.clinbiochem.2018.03.012. Epub 2018 Mar 16.
- Leisegang K, Dutta S. Do lifestyle practices impede male fertility? Andrologia. 2021 Feb;53(1):e13595. doi: 10.1111/and.13595. Epub 2020 Apr 24.
- Hanson BM, Aston KI, Jenkins TG, Carrell DT, Hotaling JM. The impact of ejaculatory abstinence on semen analysis parameters: a systematic review. J Assist Reprod Genet. 2018 Feb;35(2):213-220. doi: 10.1007/s10815-017-1086-0. Epub 2017 Nov 16.
- Barbagallo F, Cannarella R, Crafa A, Manna C, La Vignera S, Condorelli RA, Calogero AE. The Impact of a Very Short Abstinence Period on Conventional Sperm Parameters and Sperm DNA Fragmentation: A Systematic Review and Meta-Analysis. J Clin Med. 2022 Dec 8;11(24):7303. doi: 10.3390/jcm11247303.
- Stanford JB, White GL, Hatasaka H. Timing intercourse to achieve pregnancy: current evidence. Obstet Gynecol. 2002 Dec;100(6):1333-41. doi: 10.1016/s0029-7844(02)02382-7.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- 2023-HS-134
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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