- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00821548
Electrostimulation of Shoulder Girdle and Quadriceps Muscles in Facioscapulohumeral Muscular Dystrophy Patients
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Autosomal dominant FSHD is characterized by selective pattern of muscle involvement. Weakness and atrophy typically involve facial and shoulder girdle muscles, and progressively anterior forearm and foreleg muscles and pelvic girdle muscles.
The physiopatholgical mechanism of this disease, due to a deletion of repeated units named D4Z4 located on 4q35, is still controversial. Up to date, no curative therapy is available for these patients. We proposed in the present study to test feasibility, clinical and biological tolerance and efficacy of shoulder muscle training by electrostimulation in a group of FSHD patients. 10 patients displaying classical FSHD phenotype participate to this study consisting in daily session of shoulder girdle and quadriceps muscles electrostimulation of 23 minutes for a period of 5 months.
We evaluated: clinical tolerance by daily pain and fatigue analogic scales, biological tolerance by measuring CK; feasibility: by measuring the monthly score of participation to sessions; the efficacy by manual muscle testing, quantitative muscle assessment, fatigue severity scale.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Nice, France
- CHU de Nice
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- 18 to 75 years old patient
- FSHD diagnosis confirmed by molecular biology
- FSHD clinical phenotype including shoulder girdle and quadriceps involvement
- Patient with Vignos scale ≤ 5 (patient able to walk)
- Patient with health insurance
- Patient that could be followed for at least 6 months
Exclusion Criteria:
- Patient with monolateral or bilateral scapular omopexia
- Patient that has already had electrostimulation training
- Patients with CK values > 5 time normal values
- Patient that has not signed informed consent
- Patient with cancer, collagenopathies or others joint diseases
- Pregnancy and breast-feeding
- Patient on guardianship or trusteeship.
- Patient actively participating to other biomedical researches or whose exclusion period is not ended
- Patient with a formal contraindication to the protocol detected by inclusion examinations
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: 1
Electrostimulation of the muscles of the scapular belt and the femoris quadristocks
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Electrostimulation of shoulder girdle and quadriceps muscles in facioscapulohumeral muscular dystrophy patients
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Clinical tolerance evaluated by fatigue and pain analogic scale. Biological tolerance:evaluated by measuring CK values.The feasibility:evaluated by considering monthly average length of sessions, monthly score of participation to sessions
Time Frame: daily, 1, 3 and 5 months
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daily, 1, 3 and 5 months
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Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Efficacy of electrostimulation training in FSHD patients will be evaluated comparing manual muscle testing, Barré test, quantitative muscle assessment, fatigue severity scale, 6 minutes walking test before the therapy
Time Frame: after 3 months of therapy and at the end of the study, after 5 months.
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after 3 months of therapy and at the end of the study, after 5 months.
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Collaborators and Investigators
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 07-CIR-01
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Facioscapulohumeral Muscular Dystrophy
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Avidity Biosciences, Inc.RecruitingPhase 1/2 Study of AOC 1020 in Adults With Facioscapulohumeral Muscular Dystrophy (FSHD) (FORTITUDE)Muscular Dystrophies | Muscular Dystrophy, Facioscapulohumeral | FSHD | Facio-Scapulo-Humeral Dystrophy | FMD | Facioscapulohumeral Muscular Dystrophy 1 | FSHD2 | FSHD1 | FMD2 | Fascioscapulohumeral Muscular Dystrophy | Fascioscapulohumeral Muscular Dystrophy Type 1 | Fascioscapulohumeral Muscular Dystrophy... and other conditionsUnited States, United Kingdom, Canada
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Centre Hospitalier Universitaire de NiceRecruitingType 1 Facioscapulohumeral Muscular DystrophyFrance
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aTyr Pharma, Inc.CompletedFacioscapulohumeral Muscular Dystrophy (FSHD)United States, Netherlands, France, Italy
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Grete Andersen, MDCompletedFSHD - Facioscapulohumeral Muscular DystrophyDenmark
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aTyr Pharma, Inc.CompletedFacioscapulohumeral Muscular Dystrophy (FSHD)United States, France, Italy
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Ning Wang, MD., PhD.Recruiting
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Fulcrum TherapeuticsActive, not recruitingFacioscapulohumeral Muscular Dystrophy (FSHD)United States, Spain, Italy, Denmark, Canada, Germany, France, Netherlands, United Kingdom
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