Prize Reinforcement Contingency Management for Cocaine Dependence: a 24-week Randomized Controlled Trial

January 28, 2015 updated by: Sylvie Petitjean, University Hospital, Basel, Switzerland
The purpose of this study is to determine whether prize-based contingency management (prizeCM) combined with cognitive behavioral therapy (CBT) is more effective in the treatment of of cocaine-dependent patients compared to CBT only. Patients were randomized to prizeCM + CBT (experimental group) or to CBT (control group) an treated over 24 weeks. It is the first trial of this type in Europe.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Switzerland
      • Basel, Switzerland, 4025
        • Universitäre Psychiatrischen Kliniken
      • Geneva, Switzerland, 1221
        • Fondation Phenix

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 60 years (ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • cocaine dependence, aged 18 or older, other dependences

Exclusion Criteria:

  • severe somatic, brain, or psychiatric disease, attention deficit disorders with medication methylphenidate

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: TREATMENT
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: SINGLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: 1
Cognitive behavioral therapy (CBT) + prize-based contingency management (prizeCM)
Behavioral: Cognitive behavioral therapy (CBT)
ACTIVE_COMPARATOR: 2
Cognitive behavioral therapy (CBT)
Behavioral: Cognitive behavioral therapy (CBT)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
retention in treatment, cocaine abstinence
Time Frame: 24 weeks
cocaine abstinence: at least 3 consecutive weeks of cocaine abstinence, the maximum number of weeks of continous abstinence and proportions of cocaine-free urine samples during the entire 24-week and at 6-month follow-up.
24 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
patients' satisfaction with the therapy, clinical measures
Time Frame: 24 weeks
patients' satisfaction with prize-based contingency management and with CBT
24 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Basel, Switzerland

Investigators

  • Principal Investigator: Sylvie A Petitjean, Dr. phil., Psychiatric Hospital of the University of Basel

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

September 1, 2008

Primary Completion (ACTUAL)

August 1, 2013

Study Completion (ACTUAL)

October 1, 2014

Study Registration Dates

First Submitted

April 6, 2009

First Submitted That Met QC Criteria

April 6, 2009

First Posted (ESTIMATE)

April 7, 2009

Study Record Updates

Last Update Posted (ESTIMATE)

January 29, 2015

Last Update Submitted That Met QC Criteria

January 28, 2015

Last Verified

January 1, 2015

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • SNF-105314-120675

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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