- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01025219
A Contribution to the Analysis of the Phenotypic Heterogeneity in Crack/Cocaine Addiction : a Case Control Study (CRACK-ANT)
March 21, 2011 updated by: University Hospital Center of Martinique
A Case Control Study on Contribution to the Analysis of the Phenotypic Heterogeneity in Crack/Cocaine Addiction
The purpose of this study is to assess the phenotypic candidates symptoms, in patients with crack/cocaine addiction, in terms of clinical comorbidities, dimensions of personality, and neuropsychological evaluations apt to be associated with genetic and genotypic characterisations, notably on the polymorphisms of the genes coding or regulating dopaminergic, norepinephrine and serotoninergic systems.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Detailed Description
Genetic studies show an association between drug addiction and the dopaminergic system and its modulators.
Nonetheless, results are contradictory, partially due to the heterogeneity of the phenotype addiction.
Placed on the trafficking route of cocaine, and homogeneously populated, Martinique is of particular interest for the study of the vulnerability of the crack/cocaine addiction.
In a precedent study, supported by a grant MILDT / INSERM 2000, on 155 men dependent to crack/cocaine and characterised with three clinical dimensions -sensation seeking, impulsivity and childhood ADHD- we found an association between each dimension and polymorphisms of DRD2 and DRD4 genes.
Study Type
Interventional
Enrollment (Anticipated)
600
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Jérôme LACOSTE, MD
- Phone Number: +596 596 55 20 44
- Email: jerome.lacoste@chu-fortdefrance.fr
Study Contact Backup
- Name: Jocelyne CRASPAG, Master
- Phone Number: +596 596 59 26 98
- Email: jocelyne.craspag@chu-fortdefrance.fr
Study Locations
-
-
Martinique
-
Fort-de-France, Martinique, France, 97261
- Recruiting
- Service de psychiatrie et addictologie - CHU de Fort-de-France
-
Contact:
- Jocelyne CRASPAG, Master
- Phone Number: +596 596 59 26 98
- Email: jocelyne.craspag@chu-fortdefrance.fr
-
Contact:
- Mickaëlle ROSE, Master
- Phone Number: +596 596 59 26 98
- Email: mickaelle.rose@chu-fortdefrance.fr
-
Principal Investigator:
- Jérôme LACOSTE, MD
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 65 years (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- Diagnosis of cocaine abuse/dependence according to DSM-IV-TR criteria
- Come from French West Indies (3 grandparents are African-Caribbean)
- Sign a written informed consent
Exclusion Criteria:
- Minor
- Men with no cocaine abuse/dependence according to DSM-IV-TR criteria
For the control:
Inclusion Criteria:
- Platelets donor
- No substance abuse/dependence according to DSM-IV-TR criteria
- Come from French West Indies (3 grandparents are African-Caribbean)
- Sign a written informed consent
Exclusion Criteria:
- Minor
- Men refusing a genetic study
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: DIAGNOSTIC
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
The specific measure that will be related to core objectives of the study is to constitute a sample collection from saliva.
Time Frame: The saliva will be collect at the end of the first visit
|
The saliva will be collect at the end of the first visit
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Jérôme LACOSTE, MD, CHU de Fort-de-France
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
December 1, 2009
Primary Completion (ANTICIPATED)
December 1, 2012
Study Completion (ANTICIPATED)
December 1, 2012
Study Registration Dates
First Submitted
December 1, 2009
First Submitted That Met QC Criteria
December 2, 2009
First Posted (ESTIMATE)
December 3, 2009
Study Record Updates
Last Update Posted (ESTIMATE)
March 22, 2011
Last Update Submitted That Met QC Criteria
March 21, 2011
Last Verified
March 1, 2011
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 09/B/01
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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