Non-interventional Observational Study on the Influence of Pramipexole on Sensory Symptoms of Restless Legs Syndrome (RLS)

Non-interventional Observational Study on the Influence of Pramipexole (PPX) on Sensory Symptoms of Restless Legs Syndrome (RLS)

The main goal of this open-label, prospective, non-controlled, non-interventional post marketing surveillance study is to evaluate how pramipexole treatment works when applied in actual practice. In actual practice patients who would have been excluded in the clinical registration studies of pramipexole in moderate to severe primary Restless Legs Syndrome (i.e. those with certain disease histories, co-morbidities and/or demographic characteristics) will also be treated with pramipexole. Thus, during this post marketing surveillance study additional information on the efficacy and safety of pramipexole in those patients will be obtained. The objectives of this post marketing surveillance study are:

• To investigate the influence of Sifrol® (pramipexole) treatment on unpleasant sensory symptoms of Restless Legs Syndrome as measured with the short form of the McGill Pain Questionnaire.
• To assess if improvement of sensory symptoms correlates with overall Restless Legs Syndrome severity (International Restless Legs Syndrome Scale for Severity) and with secondary symptoms like sleeping problems and daytime tiredness (items 1 & 6 from Restless Legs Syndrome-6).
• To evaluate if the treatment effect of Sifrol on overall Restless Legs Syndrome severity (International Restless Legs Syndrome Scale for Severity) differs between patients with high pain scores and patients with lower pain scores.
• To compare General Practitioner and neurologist sites patient populations in terms of demographics, Restless Legs Syndrome severity at Visit 1 and treatment outcomes at Visit 3.
• To evaluate the development of behavioural changes under pramipexole treatment.

Study Overview

• Status: Completed
• Conditions: Restless Legs Syndrome

Detailed Description

Study Design:

• Study Type: Observational
• Enrollment (Actual): 1504

Contacts and Locations

Study Locations

• Germany
  • Aalen, Germany
    • Boehringer Ingelheim Investigational Site
  • Achim, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Achim, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Ahrensburg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Ahrensburg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Albstadt, Germany
    • Boehringer Ingelheim Investigational Site
  • Alfeld, Germany
    • Boehringer Ingelheim Investigational Site
  • Allendorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Alzenau, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Alzenau, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Anklam, Germany
    • Boehringer Ingelheim Investigational Site
  • Annaberg-Buchholz, Germany
    • Boehringer Ingelheim Investigational Site
  • Ansbach, Germany
    • Boehringer Ingelheim Investigational Site
  • Apolda, Germany
    • Boehringer Ingelheim Investigational Site
  • Arenshausen, Germany
    • Boehringer Ingelheim Investigational Site
  • Arnsberg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Arnsberg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Asperg, Germany
    • Boehringer Ingelheim Investigational Site
  • Attendorn, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Attendorn, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Aue, Germany
    • Boehringer Ingelheim Investigational Site
  • Augsburg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Augsburg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Augsburg, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Aurich, Germany
    • Boehringer Ingelheim Investigational Site
  • Backnang, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Arolsen, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Bevensen, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Ems, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Hersfeld, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Bad Hersfeld, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Bad Honnef, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Bad Honnef, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Bad Krozingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Laer, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Lausick, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Marienberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Neuenahr-Ahrweiler, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Bad Neuenahr-Ahrweiler, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Bad Neustadt, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Reichenhall, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Sachsa, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Salzuflen, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Salzungen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Bad Salzungen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Bad Salzungen, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Bad Schwartau, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Segeberg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Bad Segeberg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Bad Sooden-Allendorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Tennstedt, Germany
    • Boehringer Ingelheim Investigational Site
  • Bad Wörishofen, Germany
    • Boehringer Ingelheim Investigational Site
  • Baden-Baden, Germany
    • Boehringer Ingelheim Investigational Site
  • Baesweiler, Germany
    • Boehringer Ingelheim Investigational Site
  • Bamberg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Bamberg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Bamberg, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Baunatal, Germany
    • Boehringer Ingelheim Investigational Site
  • Bautzen, Germany
    • Boehringer Ingelheim Investigational Site
  • Bayreuth, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Bayreuth, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Bergheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Bergkamen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Bergkamen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 10
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 11
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 14
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 19
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 26
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 28
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 33
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 8
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 9
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 31
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 32
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 12
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 13
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 15
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 6
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 7
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 16
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 17
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 18
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 20
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 21
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 22
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 23
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 24
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 25
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 27
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 29
  • Berlin, Germany
    • Boehringer Ingelheim Investigational Site 30
  • Biberach, Germany
    • Boehringer Ingelheim Investigational Site
  • Bielefeld, Germany
    • Boehringer Ingelheim Investigational Site
  • Bingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Bissendorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Bitterfeld, Germany
    • Boehringer Ingelheim Investigational Site
  • Blankenhagen, Germany
    • Boehringer Ingelheim Investigational Site
  • Blaustein, Germany
    • Boehringer Ingelheim Investigational Site
  • Blieskastel, Germany
    • Boehringer Ingelheim Investigational Site
  • Bochum, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Bochum, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Bochum, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Bochum, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Bochum, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Bochum, Germany
    • Boehringer Ingelheim Investigational Site 6
  • Bochum, Germany
    • Boehringer Ingelheim Investigational Site 7
  • Bockhorn, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Bockhorn, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Bodelshausen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Bodelshausen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Bonn, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Bonn, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Bordesholm, Germany
    • Boehringer Ingelheim Investigational Site
  • Bottrop, Germany
    • Boehringer Ingelheim Investigational Site
  • Braunschweig, Germany
    • Boehringer Ingelheim Investigational Site
  • Bremen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Bremen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Bremen, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Bremerhaven, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Bremerhaven, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Bremerhaven, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Breuberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Bruchsal, Germany
    • Boehringer Ingelheim Investigational Site
  • Brühl, Germany
    • Boehringer Ingelheim Investigational Site
  • Buchbach, Germany
    • Boehringer Ingelheim Investigational Site
  • Buchen, Germany
    • Boehringer Ingelheim Investigational Site
  • Burgdorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Burglengenfeld, Germany
    • Boehringer Ingelheim Investigational Site
  • Burscheid, Germany
    • Boehringer Ingelheim Investigational Site
  • Butzbach, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Butzbach, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Buxtehude, Germany
    • Boehringer Ingelheim Investigational Site
  • Büchen, Germany
    • Boehringer Ingelheim Investigational Site
  • Bückeburg, Germany
    • Boehringer Ingelheim Investigational Site
  • Calw, Germany
    • Boehringer Ingelheim Investigational Site
  • Celle, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Celle, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Chemnitz, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Chemnitz, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Chemnitz, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Chemnitz, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Chemnitz, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Coburg, Germany
    • Boehringer Ingelheim Investigational Site
  • Coesfeld, Germany
    • Boehringer Ingelheim Investigational Site
  • Cottbus, Germany
    • Boehringer Ingelheim Investigational Site
  • Crimmitschau, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Crimmitschau, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Dachau, Germany
    • Boehringer Ingelheim Investigational Site
  • Delbrück, Germany
    • Boehringer Ingelheim Investigational Site
  • Delmenhorst, Germany
    • Boehringer Ingelheim Investigational Site
  • Dernau, Germany
    • Boehringer Ingelheim Investigational Site
  • Dessau, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Dessau, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Dessau, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Dessau, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Dietzenbach, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Dietzenbach, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Dietzenbach, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Dillingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Dinkelsbühl, Germany
    • Boehringer Ingelheim Investigational Site
  • Dippoldiswalde, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Dippoldiswalde, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Dortmund, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Dortmund, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Dortmund, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Dortmund, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Dresden, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Dresden, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Dresden, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Driedorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Duderstadt, Germany
    • Boehringer Ingelheim Investigational Site
  • Duisburg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Duisburg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Duisburg, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Durmersheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Döbeln, Germany
    • Boehringer Ingelheim Investigational Site
  • Dörentrup, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Dörentrup, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Düsseldorf, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Düsseldorf, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Düsseldorf, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Düsseldorf, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Düsseldorf, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Düsseldorf, Germany
    • Boehringer Ingelheim Investigational Site 6
  • Düsseldorf, Germany
    • Boehringer Ingelheim Investigational Site 7
  • Düsseldorf, Germany
    • Boehringer Ingelheim Investigational Site 8
  • Düsseldorf, Germany
    • Boehringer Ingelheim Investigational Site 9
  • Ebermannstadt, Germany
    • Boehringer Ingelheim Investigational Site
  • Edingen-Neckarhausen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Edingen-Neckarhausen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Edling, Germany
    • Boehringer Ingelheim Investigational Site
  • Eilenburg, Germany
    • Boehringer Ingelheim Investigational Site
  • Eisenach, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Eisenach, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Eisenberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Eisenhüttenstadt, Germany
    • Boehringer Ingelheim Investigational Site
  • Ellwangen, Germany
    • Boehringer Ingelheim Investigational Site
  • Emmendingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Emsdetten, Germany
    • Boehringer Ingelheim Investigational Site
  • Emskirchen, Germany
    • Boehringer Ingelheim Investigational Site
  • Enkirch, Germany
    • Boehringer Ingelheim Investigational Site
  • Ennigerloh, Germany
    • Boehringer Ingelheim Investigational Site
  • Eppelheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Erbach, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Erbach, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Erbach, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Erfurt, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Erfurt, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Erfurt, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Erkrath, Germany
    • Boehringer Ingelheim Investigational Site
  • Erlangen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Eschborn, Germany
    • Boehringer Ingelheim Investigational Site
  • Eschlkam, Germany
    • Boehringer Ingelheim Investigational Site
  • Essen, Germany
    • Boehringer Ingelheim Investigational Site 10
  • Essen, Germany
    • Boehringer Ingelheim Investigational Site 11
  • Essen, Germany
    • Boehringer Ingelheim Investigational Site 12
  • Essen, Germany
    • Boehringer Ingelheim Investigational Site 13
  • Essen, Germany
    • Boehringer Ingelheim Investigational Site 14
  • Essen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Essen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Essen, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Essen, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Essen, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Essen, Germany
    • Boehringer Ingelheim Investigational Site 6
  • Essen, Germany
    • Boehringer Ingelheim Investigational Site 7
  • Essen, Germany
    • Boehringer Ingelheim Investigational Site 8
  • Essen, Germany
    • Boehringer Ingelheim Investigational Site 9
  • Ettlingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Extertal, Germany
    • Boehringer Ingelheim Investigational Site
  • Falkenhagen, Germany
    • Boehringer Ingelheim Investigational Site
  • Fehrbellin, Germany
    • Boehringer Ingelheim Investigational Site
  • Flintbek, Germany
    • Boehringer Ingelheim Investigational Site
  • Frankfurt, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Frankfurt, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Frankfurt, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Freiberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Freiburg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Freiburg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Freiburg, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Freiburg, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Freiburg, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Freilassing, Germany
    • Boehringer Ingelheim Investigational Site
  • Freinsheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Freital, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Freital, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Freital, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Friedrichshafen, Germany
    • Boehringer Ingelheim Investigational Site
  • Friedrichsthal, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Friedrichsthal, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Fulda, Germany
    • Boehringer Ingelheim Investigational Site
  • Fürstenfeldbruck, Germany
    • Boehringer Ingelheim Investigational Site
  • Fürstenwalde, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Fürstenwalde, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Fürstenzell, Germany
    • Boehringer Ingelheim Investigational Site
  • Fürth, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Fürth, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Gauting, Germany
    • Boehringer Ingelheim Investigational Site
  • Geisenhausen, Germany
    • Boehringer Ingelheim Investigational Site
  • Geithain, Germany
    • Boehringer Ingelheim Investigational Site
  • Gelnhausen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Gelnhausen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Gelsenkirchen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Gelsenkirchen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Gelsenkirchen, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Gelsenkirchen, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Gera, Germany
    • Boehringer Ingelheim Investigational Site
  • Gerbstedt, Germany
    • Boehringer Ingelheim Investigational Site
  • Germering, Germany
    • Boehringer Ingelheim Investigational Site
  • Gersthofen, Germany
    • Boehringer Ingelheim Investigational Site
  • Gingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Gladbeck, Germany
    • Boehringer Ingelheim Investigational Site
  • Gladenbach, Germany
    • Boehringer Ingelheim Investigational Site
  • Glauchau, Germany
    • Boehringer Ingelheim Investigational Site
  • Gleichen, Germany
    • Boehringer Ingelheim Investigational Site
  • Glienicke, Germany
    • Boehringer Ingelheim Investigational Site
  • Glücksburg, Germany
    • Boehringer Ingelheim Investigational Site
  • Gosheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Greifswald, Germany
    • Boehringer Ingelheim Investigational Site
  • Greven, Germany
    • Boehringer Ingelheim Investigational Site
  • Grevenbroich, Germany
    • Boehringer Ingelheim Investigational Site
  • Großefehn, Germany
    • Boehringer Ingelheim Investigational Site
  • Großmaischeid, Germany
    • Boehringer Ingelheim Investigational Site
  • Grömitz, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Grömitz, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Grüna, Germany
    • Boehringer Ingelheim Investigational Site
  • Grünheide, Germany
    • Boehringer Ingelheim Investigational Site
  • Grünstadt, Germany
    • Boehringer Ingelheim Investigational Site
  • Gudensberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Gundelfingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Göppingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Göttingen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Göttingen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Göttingen, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Göttingen, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Göttingen, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Gößweinstein, Germany
    • Boehringer Ingelheim Investigational Site
  • Güster, Germany
    • Boehringer Ingelheim Investigational Site
  • Haag, Germany
    • Boehringer Ingelheim Investigational Site
  • Halbe, Germany
    • Boehringer Ingelheim Investigational Site
  • Halle, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Halle, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Halle, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Halle, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Halle, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 22
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 6
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 10
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 11
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 12
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 13
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 14
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 15
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 16
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 17
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 18
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 19
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 20
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 21
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 23
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 24
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 25
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 7
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 8
  • Hamburg, Germany
    • Boehringer Ingelheim Investigational Site 9
  • Hameln, Germany
    • Boehringer Ingelheim Investigational Site
  • Hammelburg, Germany
    • Boehringer Ingelheim Investigational Site
  • Hamminkeln, Germany
    • Boehringer Ingelheim Investigational Site
  • Hann Münden, Germany
    • Boehringer Ingelheim Investigational Site
  • Hannover, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Hannover, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Hannover, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Hannover, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Hannover, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Hannover, Germany
    • Boehringer Ingelheim Investigational Site 6
  • Hannover, Germany
    • Boehringer Ingelheim Investigational Site 7
  • Harsewinkel, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Harsewinkel, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Harsewinkel, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Hartenstein, Germany
    • Boehringer Ingelheim Investigational Site
  • Hasbergen, Germany
    • Boehringer Ingelheim Investigational Site
  • Heilbad Heiligenstadt, Germany
    • Boehringer Ingelheim Investigational Site
  • Heilbronn, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Heilbronn, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Heilbronn, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Heinsberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Herborn, Germany
    • Boehringer Ingelheim Investigational Site
  • Herbrechtingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Herdorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Herne, Germany
    • Boehringer Ingelheim Investigational Site
  • Herrenberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Herrnhut, Germany
    • Boehringer Ingelheim Investigational Site
  • Herrsching, Germany
    • Boehringer Ingelheim Investigational Site
  • Herzogenrath, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Herzogenrath, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Hessisch Lichtenau, Germany
    • Boehringer Ingelheim Investigational Site
  • Hettstedt, Germany
    • Boehringer Ingelheim Investigational Site
  • Hildburghausen, Germany
    • Boehringer Ingelheim Investigational Site
  • Hildesheim, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Hildesheim, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Hildesheim, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Hildesheim, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Hof, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Hof, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Hohenprießnitz, Germany
    • Boehringer Ingelheim Investigational Site
  • Holle, Germany
    • Boehringer Ingelheim Investigational Site
  • Horb, Germany
    • Boehringer Ingelheim Investigational Site
  • Höchberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Hückeswagen, Germany
    • Boehringer Ingelheim Investigational Site
  • Hüllhorst, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Hüllhorst, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Hüllhorst, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Hürth, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Hürth, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Ibbenbüren, Germany
    • Boehringer Ingelheim Investigational Site
  • Ilmenau, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Ilmenau, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Immenstadt, Germany
    • Boehringer Ingelheim Investigational Site
  • Ingelfingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Ingelheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Ingolstadt, Germany
    • Boehringer Ingelheim Investigational Site
  • Inning, Germany
    • Boehringer Ingelheim Investigational Site
  • Irsch, Germany
    • Boehringer Ingelheim Investigational Site
  • Iserlohn, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Iserlohn, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Itzehoe, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Itzehoe, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Itzehoe, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Jettingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Jülich, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Jülich, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Jülich, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Jüterbog, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Jüterbog, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Kaiserslautern, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Kaiserslautern, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Kamen, Germany
    • Boehringer Ingelheim Investigational Site
  • Kandel, Germany
    • Boehringer Ingelheim Investigational Site
  • Karlsfeld, Germany
    • Boehringer Ingelheim Investigational Site
  • Karlsruhe, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Karlsruhe, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Kassel, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Kassel, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Kassel, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Kassel, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Kaufbeuren, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Kaufbeuren, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Kaufbeuren, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Kempten, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Kempten, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Kenzingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Kernen, Germany
    • Boehringer Ingelheim Investigational Site
  • Kiel, Germany
    • Boehringer Ingelheim Investigational Site
  • Kirchardt, Germany
    • Boehringer Ingelheim Investigational Site
  • Kirchen, Germany
    • Boehringer Ingelheim Investigational Site
  • Kirchheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Kirchheimbolanden, Germany
    • Boehringer Ingelheim Investigational Site
  • Kißlegg, Germany
    • Boehringer Ingelheim Investigational Site
  • Kleve, Germany
    • Boehringer Ingelheim Investigational Site
  • Klingenberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Konz, Germany
    • Boehringer Ingelheim Investigational Site
  • Krefeld, Germany
    • Boehringer Ingelheim Investigational Site
  • Kreuztal, Germany
    • Boehringer Ingelheim Investigational Site
  • Kronach, Germany
    • Boehringer Ingelheim Investigational Site
  • Köln, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Köln, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Köln, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Köln, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Köln, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Köln, Germany
    • Boehringer Ingelheim Investigational Site 6
  • Köln, Germany
    • Boehringer Ingelheim Investigational Site 7
  • Köln, Germany
    • Boehringer Ingelheim Investigational Site 8
  • Köln, Germany
    • Boehringer Ingelheim Investigational Site 9
  • Königsbrunn, Germany
    • Boehringer Ingelheim Investigational Site
  • Kösching, Germany
    • Boehringer Ingelheim Investigational Site
  • Köthen, Germany
    • Boehringer Ingelheim Investigational Site
  • Laage, Germany
    • Boehringer Ingelheim Investigational Site
  • Lahnau, Germany
    • Boehringer Ingelheim Investigational Site
  • Laichingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Lampertheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Landshut, Germany
    • Boehringer Ingelheim Investigational Site
  • Langen, Germany
    • Boehringer Ingelheim Investigational Site
  • Langerwehe, Germany
    • Boehringer Ingelheim Investigational Site
  • Lauterbach, Germany
    • Boehringer Ingelheim Investigational Site
  • Leipzig, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Leipzig, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Leipzig, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Leipzig, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Leipzig, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Leipzig, Germany
    • Boehringer Ingelheim Investigational Site 6
  • Leipzig, Germany
    • Boehringer Ingelheim Investigational Site 7
  • Leipzig, Germany
    • Boehringer Ingelheim Investigational Site 8
  • Leipzig, Germany
    • Boehringer Ingelheim Investigational Site 9
  • Leverkusen, Germany
    • Boehringer Ingelheim Investigational Site
  • Lichtenfels, Germany
    • Boehringer Ingelheim Investigational Site
  • Limburg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Limburg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Limburgerhof, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Limburgerhof, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Lingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Linz, Germany
    • Boehringer Ingelheim Investigational Site
  • Lippstadt, Germany
    • Boehringer Ingelheim Investigational Site
  • Lohr, Germany
    • Boehringer Ingelheim Investigational Site
  • Ludwigsfelde, Germany
    • Boehringer Ingelheim Investigational Site
  • Ludwigshafen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Ludwigshafen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Lübbenau, Germany
    • Boehringer Ingelheim Investigational Site
  • Lübeck, Germany
    • Boehringer Ingelheim Investigational Site
  • Lüdenscheid, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Lüdenscheid, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Lüneburg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Lüneburg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Magdeburg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Magdeburg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Mainaschaff, Germany
    • Boehringer Ingelheim Investigational Site
  • Mannheim, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Mannheim, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Mannheim, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Mannheim, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Mannheim, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Mannheim, Germany
    • Boehringer Ingelheim Investigational Site 6
  • Mannheim, Germany
    • Boehringer Ingelheim Investigational Site 7
  • Margetshöchheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Markdorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Markkleeberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Marl, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Marl, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Mayen, Germany
    • Boehringer Ingelheim Investigational Site
  • Meckenheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Meerbusch, Germany
    • Boehringer Ingelheim Investigational Site
  • Meinhard, Germany
    • Boehringer Ingelheim Investigational Site
  • Meißen, Germany
    • Boehringer Ingelheim Investigational Site
  • Mendig, Germany
    • Boehringer Ingelheim Investigational Site
  • Merseburg, Germany
    • Boehringer Ingelheim Investigational Site
  • Metzingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Mittenwald, Germany
    • Boehringer Ingelheim Investigational Site
  • Mitterfelden, Germany
    • Boehringer Ingelheim Investigational Site
  • Molfsee, Germany
    • Boehringer Ingelheim Investigational Site
  • Monheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Moormerland, Germany
    • Boehringer Ingelheim Investigational Site
  • Moosburg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Moosburg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Mosbach, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Mosbach, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Murrhardt, Germany
    • Boehringer Ingelheim Investigational Site
  • Mutterstadt, Germany
    • Boehringer Ingelheim Investigational Site
  • Mönchengladbach, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Mönchengladbach, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Mühlheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Mülheim, Germany
    • Boehringer Ingelheim Investigational Site
  • München, Germany
    • Boehringer Ingelheim Investigational Site 3
  • München, Germany
    • Boehringer Ingelheim Investigational Site 7
  • München, Germany
    • Boehringer Ingelheim Investigational Site 1
  • München, Germany
    • Boehringer Ingelheim Investigational Site 2
  • München, Germany
    • Boehringer Ingelheim Investigational Site 4
  • München, Germany
    • Boehringer Ingelheim Investigational Site 5
  • München, Germany
    • Boehringer Ingelheim Investigational Site 10
  • München, Germany
    • Boehringer Ingelheim Investigational Site 11
  • München, Germany
    • Boehringer Ingelheim Investigational Site 6
  • München, Germany
    • Boehringer Ingelheim Investigational Site 8
  • München, Germany
    • Boehringer Ingelheim Investigational Site 9
  • Münchweiler, Germany
    • Boehringer Ingelheim Investigational Site
  • Münster, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Münster, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Münster, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Nagold, Germany
    • Boehringer Ingelheim Investigational Site
  • Naundorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Nettetal, Germany
    • Boehringer Ingelheim Investigational Site
  • Neubrandenburg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Neubrandenburg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Neuhaus, Germany
    • Boehringer Ingelheim Investigational Site
  • Neuhof, Germany
    • Boehringer Ingelheim Investigational Site
  • Neukirchen-Vluyn, Germany
    • Boehringer Ingelheim Investigational Site
  • Neumarkt, Germany
    • Boehringer Ingelheim Investigational Site
  • Neuss, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Neuss, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Neuss, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Neustadt, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Neustadt, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Neustadt, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Neustrelitz, Germany
    • Boehringer Ingelheim Investigational Site
  • Niederlehme, Germany
    • Boehringer Ingelheim Investigational Site
  • Niedernwöhren, Germany
    • Boehringer Ingelheim Investigational Site
  • Nienstädt, Germany
    • Boehringer Ingelheim Investigational Site
  • Nordstemmen, Germany
    • Boehringer Ingelheim Investigational Site
  • Nossen, Germany
    • Boehringer Ingelheim Investigational Site
  • Notzingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Nürnberg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Nürnberg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Oberhausen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Oberhausen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Oberhausen, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Oberkirch, Germany
    • Boehringer Ingelheim Investigational Site
  • Oer-Erkenschwick, Germany
    • Boehringer Ingelheim Investigational Site
  • Offenbach, Germany
    • Boehringer Ingelheim Investigational Site
  • Offenburg, Germany
    • Boehringer Ingelheim Investigational Site
  • Olching, Germany
    • Boehringer Ingelheim Investigational Site
  • Oldenburg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Oldenburg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Olpe, Germany
    • Boehringer Ingelheim Investigational Site
  • Oppenheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Oranienburg, Germany
    • Boehringer Ingelheim Investigational Site
  • Osnabrück, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Osnabrück, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Osnabrück, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Osnabrück, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Ostrach, Germany
    • Boehringer Ingelheim Investigational Site
  • Otterbach, Germany
    • Boehringer Ingelheim Investigational Site
  • Otterndorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Ottobrunn, Germany
    • Boehringer Ingelheim Investigational Site
  • Overath, Germany
    • Boehringer Ingelheim Investigational Site
  • Oy-Mittelberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Paderborn, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Paderborn, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Paderborn, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Paderborn, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Parchim, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Parchim, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Parey, Germany
    • Boehringer Ingelheim Investigational Site
  • Passau, Germany
    • Boehringer Ingelheim Investigational Site
  • Peine, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Peine, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Peiting, Germany
    • Boehringer Ingelheim Investigational Site
  • Pfarrkirchen, Germany
    • Boehringer Ingelheim Investigational Site
  • Pforzheim, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Pforzheim, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Pirna, Germany
    • Boehringer Ingelheim Investigational Site
  • Plettenberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Potsdam, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Potsdam, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Potsdam, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Potsdam, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Potsdam, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Potsdam, Germany
    • Boehringer Ingelheim Investigational Site 6
  • Preetz, Germany
    • Boehringer Ingelheim Investigational Site
  • Prenzlau, Germany
    • Boehringer Ingelheim Investigational Site
  • Prien, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Prien, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Pulheim, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Pulheim, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Radeberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Radevormwald, Germany
    • Boehringer Ingelheim Investigational Site
  • Rain, Germany
    • Boehringer Ingelheim Investigational Site
  • Rastatt, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Regen, Germany
    • Boehringer Ingelheim Investigational Site
  • Regensburg, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Regensburg, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Regensburg, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Regensburg, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Reichenbach, Germany
    • Boehringer Ingelheim Investigational Site
  • Reinbek, Germany
    • Boehringer Ingelheim Investigational Site
  • Remscheid, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Remscheid, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Remscheid, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Remscheid, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Remscheid, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Remscheid, Germany
    • Boehringer Ingelheim Investigational Site 6
  • Rendsburg, Germany
    • Boehringer Ingelheim Investigational Site
  • Rheine, Germany
    • Boehringer Ingelheim Investigational Site
  • Rodewisch, Germany
    • Boehringer Ingelheim Investigational Site
  • Rostock, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Rostock, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Rostock, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Rostock, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Röcknitz, Germany
    • Boehringer Ingelheim Investigational Site
  • Rödermark, Germany
    • Boehringer Ingelheim Investigational Site
  • Rüsselsheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Saarbrücken, Germany
    • Boehringer Ingelheim Investigational Site
  • Salzgitter, Germany
    • Boehringer Ingelheim Investigational Site
  • Scharnebeck, Germany
    • Boehringer Ingelheim Investigational Site
  • Schirgiswalde, Germany
    • Boehringer Ingelheim Investigational Site
  • Schleching, Germany
    • Boehringer Ingelheim Investigational Site
  • Schleiden, Germany
    • Boehringer Ingelheim Investigational Site
  • Schleswig, Germany
    • Boehringer Ingelheim Investigational Site
  • Schloß Holte-Stukenbrock, Germany
    • Boehringer Ingelheim Investigational Site
  • Schriesheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Schwaig, Germany
    • Boehringer Ingelheim Investigational Site
  • Schwalmstadt, Germany
    • Boehringer Ingelheim Investigational Site
  • Schwanewede, Germany
    • Boehringer Ingelheim Investigational Site
  • Schwarzenbach a Wald, Germany
    • Boehringer Ingelheim Investigational Site
  • Schwarzenberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Schwarzenbruck, Germany
    • Boehringer Ingelheim Investigational Site
  • Schwerte, Germany
    • Boehringer Ingelheim Investigational Site
  • Schwäbisch Gmünd, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Schwäbisch Gmünd, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Schönebeck, Germany
    • Boehringer Ingelheim Investigational Site
  • Schönfeld, Germany
    • Boehringer Ingelheim Investigational Site
  • Seeheim-Jugenheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Seifhennersdorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Selbitz, Germany
    • Boehringer Ingelheim Investigational Site
  • Senden, Germany
    • Boehringer Ingelheim Investigational Site
  • Sendenhorst, Germany
    • Boehringer Ingelheim Investigational Site
  • Senftenberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Siegen, Germany
    • Boehringer Ingelheim Investigational Site
  • Sigmaringen, Germany
    • Boehringer Ingelheim Investigational Site
  • Simmern, Germany
    • Boehringer Ingelheim Investigational Site
  • Sindelfingen, Germany
    • Boehringer Ingelheim Investigational Site
  • Sinsheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Soest, Germany
    • Boehringer Ingelheim Investigational Site
  • Sondershausen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Sondershausen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Sonsbeck, Germany
    • Boehringer Ingelheim Investigational Site
  • Spremberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Stade, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Stade, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Stamsried, Germany
    • Boehringer Ingelheim Investigational Site
  • Steinfeld, Germany
    • Boehringer Ingelheim Investigational Site
  • Steinmauern, Germany
    • Boehringer Ingelheim Investigational Site
  • Stendal, Germany
    • Boehringer Ingelheim Investigational Site
  • Sternberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Stolberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Stollberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Stolpen, Germany
    • Boehringer Ingelheim Investigational Site
  • Stotternheim, Germany
    • Boehringer Ingelheim Investigational Site
  • Straelen, Germany
    • Boehringer Ingelheim Investigational Site
  • Stralsund, Germany
    • Boehringer Ingelheim Investigational Site
  • Straubing, Germany
    • Boehringer Ingelheim Investigational Site
  • Stuhr, Germany
    • Boehringer Ingelheim Investigational Site
  • Stuttgart, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Stuttgart, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Stuttgart, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Stuttgart, Germany
    • Boehringer Ingelheim Investigational Site 10
  • Stuttgart, Germany
    • Boehringer Ingelheim Investigational Site 11
  • Stuttgart, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Stuttgart, Germany
    • Boehringer Ingelheim Investigational Site 5
  • Stuttgart, Germany
    • Boehringer Ingelheim Investigational Site 6
  • Stuttgart, Germany
    • Boehringer Ingelheim Investigational Site 7
  • Stuttgart, Germany
    • Boehringer Ingelheim Investigational Site 8
  • Stuttgart, Germany
    • Boehringer Ingelheim Investigational Site 9
  • Sömmerda, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Sömmerda, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Telgte, Germany
    • Boehringer Ingelheim Investigational Site
  • Templin, Germany
    • Boehringer Ingelheim Investigational Site
  • Tirschenreuth, Germany
    • Boehringer Ingelheim Investigational Site
  • Trier, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Trier, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Trier, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Ulm, Germany
    • Boehringer Ingelheim Investigational Site
  • Velen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Velen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Vellmar, Germany
    • Boehringer Ingelheim Investigational Site
  • Velten, Germany
    • Boehringer Ingelheim Investigational Site
  • Verden, Germany
    • Boehringer Ingelheim Investigational Site
  • Viersen, Germany
    • Boehringer Ingelheim Investigational Site
  • Vilshofen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Vilshofen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Vilshofen, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Visselhövede, Germany
    • Boehringer Ingelheim Investigational Site
  • Waghäusel, Germany
    • Boehringer Ingelheim Investigational Site
  • Wahlstedt, Germany
    • Boehringer Ingelheim Investigational Site
  • Wald-Michelbach, Germany
    • Boehringer Ingelheim Investigational Site
  • Waldkraiburg, Germany
    • Boehringer Ingelheim Investigational Site
  • Wandlitz, Germany
    • Boehringer Ingelheim Investigational Site
  • Wankendorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Warthausen, Germany
    • Boehringer Ingelheim Investigational Site
  • Wegberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Wehrsdorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Weingarten, Germany
    • Boehringer Ingelheim Investigational Site
  • Weinsberg, Germany
    • Boehringer Ingelheim Investigational Site
  • Weißenfels, Germany
    • Boehringer Ingelheim Investigational Site
  • Welbsleben, Germany
    • Boehringer Ingelheim Investigational Site
  • Welver, Germany
    • Boehringer Ingelheim Investigational Site
  • Wernigerode, Germany
    • Boehringer Ingelheim Investigational Site
  • Werningshausen, Germany
    • Boehringer Ingelheim Investigational Site
  • Wesel, Germany
    • Boehringer Ingelheim Investigational Site
  • Wessobrunn, Germany
    • Boehringer Ingelheim Investigational Site
  • Westoverledingen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Westoverledingen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Wiesbaden, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Wiesbaden, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Wiesbaden, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Wiesenfelden, Germany
    • Boehringer Ingelheim Investigational Site
  • Wietzen, Germany
    • Boehringer Ingelheim Investigational Site
  • Wildau, Germany
    • Boehringer Ingelheim Investigational Site
  • Wilhelmshaven, Germany
    • Boehringer Ingelheim Investigational Site
  • Wilhermsdorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Willich, Germany
    • Boehringer Ingelheim Investigational Site
  • Winkelhaid, Germany
    • Boehringer Ingelheim Investigational Site
  • Winsen, Germany
    • Boehringer Ingelheim Investigational Site
  • Wismar, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Wismar, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Wismar, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Wissen, Germany
    • Boehringer Ingelheim Investigational Site
  • Wittgensdorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Witzenhausen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Witzenhausen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Witzenhausen, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Wolfenbüttel, Germany
    • Boehringer Ingelheim Investigational Site
  • Wolfratshausen, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Wolfratshausen, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Wolfratshausen, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Wolfsburg, Germany
    • Boehringer Ingelheim Investigational Site
  • Wolgast, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Worms, Germany
    • Boehringer Ingelheim Investigational Site
  • Wunstorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Wuppertal, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Wuppertal, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Wuppertal, Germany
    • Boehringer Ingelheim Investigational Site 3
  • Wuppertal, Germany
    • Boehringer Ingelheim Investigational Site 4
  • Wustrau, Germany
    • Boehringer Ingelheim Investigational Site
  • Wörrstadt, Germany
    • Boehringer Ingelheim Investigational Site
  • Wörth, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Wörth, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Würzburg, Germany
    • Boehringer Ingelheim Investigational Site
  • Zeitz, Germany
    • Boehringer Ingelheim Investigational Site
  • Zella-Mehlis, Germany
    • Boehringer Ingelheim Investigational Site
  • Zerbst, Germany
    • Boehringer Ingelheim Investigational Site
  • Ziltendorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Zirndorf, Germany
    • Boehringer Ingelheim Investigational Site
  • Zorge, Germany
    • Boehringer Ingelheim Investigational Site
  • Zschopau, Germany
    • Boehringer Ingelheim Investigational Site
  • Zwickau, Germany
    • Boehringer Ingelheim Investigational Site 1
  • Zwickau, Germany
    • Boehringer Ingelheim Investigational Site 2
  • Zwönitz, Germany
    • Boehringer Ingelheim Investigational Site
  • Übach-Palenberg, Germany
    • Boehringer Ingelheim Investigational Site

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

RLS patients

Description

Inclusion criteria:

1. Diagnosis of primary moderate to severe Restless Legs Syndrome.
2. Patients who are planned to be treated with Sifrol® (pramipexole) and where the decision of treatment is made independent of the patients' inclusion into this post marketing surveillance study.
3. Male or female patients aged at least 18 years.
4. Written informed consent by the patient for study participation.

Exclusion criteria:

1. Any contraindications according to the Summary of Product Characteristics: hypersensitivity to pramipexole or to any of the excipients.
2. Previous or ongoing treatment with Sifrol® (pramipexole).
3. Previous or ongoing treatment with dopamine receptor agonists.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Summary of Change From Baseline in Total Sum of McGill Pain Questionnaire to Visit 3	Change in Total Sum Score of McGill Pain Questionnaire at Visit 3 to baseline. The sum scores can have values in the range from 0 (no pain) to 20 (worst pain). A negative change is an improvement of pain, a positive change a worsening of pain.	Baseline to Visit 3
Summary of Change From Baseline in Total Sum of McGill Pain Questionnaire to Visit 3 for Patients Treated by General Practitioner	Change in Total Sum Score of McGill Pain Questionnaire at Visit 3 to baseline. The sum scores can have values in the range from 0 (no pain) to 20 (worst pain). A negative change is an improvement of pain, a positive change a worsening of pain.	Baseline to Visit 3
Summary of Change From Baseline in Total Sum of McGill Pain Questionnaire to Visit 3 for Patients Treated by Neurologist	Change in Total Sum Score of McGill Pain Questionnaire at Visit 3 to baseline. The sum scores can have values in the range from 0 (no pain) to 20 (worst pain). A negative change is an improvement of pain, a positive change a worsening of pain.	Baseline to Visit 3

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Summary of Change From Baseline in Restless Legs Syndrome Severity Scale With 6 Questions to Visit 3	Change in RLS-6 at Visit 3 to baseline. The sum scores can have values in the range from 0 (best) to 20 (worst) A negative change is an improvement of RLS-6, a positive change a worsening of RLS-6.	Baseline to Visit 3
Summary of Change From Baseline in International Restless Legs Syndrome Scale for Severity to Visit 3	Change in IRLS at Visit 3 to baseline. The sum scores can have values in the range from 0 (best) to 40 (worst) A negative change is an improvement of IRLS, a positive change a worsening of IRLS.	Baseline to Visit 3
Behavioural Changes During Treatment	Number of patients with occurence of behavioural changes in terms of impulse control disorders	Baseline to Visit 3

Collaborators and Investigators

• Sponsor: Boehringer Ingelheim

Publications and helpful links

Helpful Links

• Related Info

Study record dates

Study Major Dates

• Study Start: April 1, 2009
• Primary Completion (ACTUAL): October 1, 2009
• Study Completion (ACTUAL): October 1, 2009

Study Registration Dates

• First Submitted: July 29, 2008
• First Submitted That Met QC Criteria: April 22, 2009
• First Posted (ESTIMATE): April 23, 2009

Study Record Updates

• Last Update Posted (ESTIMATE): June 27, 2014
• Last Update Submitted That Met QC Criteria: June 17, 2014
• Last Verified: March 1, 2014

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Pathologic Processes; Nervous System Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Neurologic Manifestations; Neurobehavioral Manifestations; Disease; Dyskinesias; Psychomotor Disorders; Parasomnias; Syndrome; Psychomotor Agitation; Restless Legs Syndrome
• Other Study ID Numbers: 248.659