- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00980434
S-100B and Neuron-specific Enolase (NSE) in Spinal Trauma (WBS)
April 3, 2012 updated by: Medical University of Vienna
The Clinical Use of S-100B and NSE in Spinal Cord Injuries
The investigators are studying the clinical worth of the serum markers S-100B and NSE in patients with spinal cord injuries e.g. in patients with vertebral fractures.
If there is a injury to the neuronal structures these two proteins could be secreted into the serum and add evidence to the severity of the injury.
Study Overview
Status
Completed
Conditions
Study Type
Observational
Enrollment (Actual)
60
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Vienna, Austria, 1090
- Medical University of Vienna
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
1 year and older (Child, Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
patients from daily practice
Description
Inclusion Criteria:
- vertebral fracture
- injuries to the vertebral spine
Exclusion Criteria:
- head trauma
- polytrauma
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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1
patients with neurological symptoms
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2
patients without neurological symptoms
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
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Neurological Symptoms
Time Frame: 2 weeks
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2 weeks
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Chair: Vilmos Vecsei, M.D. Professor, head of department
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Marquardt G, Setzer M, Seifert V. Protein S-100b as serum marker for prediction of functional outcome in metastatic spinal cord compression. Acta Neurochir (Wien). 2004 May;146(5):449-52. doi: 10.1007/s00701-004-0242-3. Epub 2004 Mar 22.
- Loy DN, Kim JH, Xie M, Schmidt RE, Trinkaus K, Song SK. Diffusion tensor imaging predicts hyperacute spinal cord injury severity. J Neurotrauma. 2007 Jun;24(6):979-90. doi: 10.1089/neu.2006.0253.
- Marquardt G, Setzer M, Seifert V. Serum biomarkers for experimental acute spinal cord injury: rapid elevation of neuron-specific enolase and S-100 beta. Neurosurgery. 2006 Mar;58(3):E590; author reply E590. doi: 10.1227/01.NEU.0000207967.91316.8D. No abstract available.
- Marquardt G, Setzer M, Seifert V. Protein S-100b for individual prediction of functional outcome in spinal epidural empyema. Spine (Phila Pa 1976). 2004 Jan 1;29(1):59-62. doi: 10.1097/01.BRS.0000103661.78939.02.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
February 1, 2008
Primary Completion (Actual)
November 1, 2011
Study Completion (Actual)
December 1, 2011
Study Registration Dates
First Submitted
September 18, 2009
First Submitted That Met QC Criteria
September 18, 2009
First Posted (Estimate)
September 21, 2009
Study Record Updates
Last Update Posted (Estimate)
April 4, 2012
Last Update Submitted That Met QC Criteria
April 3, 2012
Last Verified
July 1, 2011
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- Wolf-4
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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