- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01007682
Intrusive Reexperiencing: The Role of Working Memory Capacity and Thought Suppression
This study aims at identifying risk factors for the development of intrusive reexperiencing symptoms. In particular, the investigators examine the influence of working memory capacity and thought suppression on the occurrence of unpleasant memories of a negative experience.
Hypothesis: People with high working memory capacities (HWMC) are able to successfully suppress memories of an unpleasant experience (presentation of a distressing movie). In contrast, in people with low working memory capacities (LWMC), attempts to suppress memories of an unpleasant experience inadvertently lead to an increase of these memories.
Study phase one: Assessment of working memory capacity in 200 healthy participants by means of a computerized task. Selection of 50 participants with HWMC and of 50 participants with LWMC who participate in study phase two.
Study phase two: Presentation of a distressing movie and subsequent assessment of memories of the movie during several days in the daily life of participants. Comparison of 4 groups regarding the frequency of instructions in daily life:(group 1: HWMC participants who are instructed to suppress thoughts of the movie, group 2: LWMC participants who are instructed to suppress thoughts of the movie, group 3: HWMC participants who are instructed to allow the occurence of thoughts of the movie, group 4: LWMC participants who are instructed to allow the occurence of thoughts of the movie)
Study Overview
Status
Conditions
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Massachusetts
-
Cambridge, Massachusetts, United States, 02138-2044
- Harvard University, Department of Psychology
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Older than 17 years
Exclusion Criteria:
- Insufficient knowledge of the German language, for the distressing movie arm of the study: Elevated levels of depression or posttraumatic stress symptoms prior to viewing of the distressing movie
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Factorial Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
No Intervention: Screening for working memory capacity
|
|
Experimental: Distressing movie
A distressing movie is presented to two groups (one group with high and one group with low working memory capacity).
For each of the two groups, half of the participants are instructed to suppress thoughts of the movies after viewing it, while the remaining participants are instructed to allow the occurrence of memories of the movie.
|
A distressing movie is presented to two groups (one group with high and one group with low working memory capacity).
For each of the two groups, half of the participants are instructed to suppress thoughts of the movies after viewing it, while the remaining participants are instructed to allow the occurrence of memories of the movie.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Number of intrusive memories
Time Frame: during one week after viewing the distressing movie
|
during one week after viewing the distressing movie
|
Collaborators and Investigators
Investigators
- Principal Investigator: Monique C Pfaltz, PhD, Harvard University, Department of Pysychology
- Study Chair: Jürgen Margraf, Prof, University of Basel, Department for Clinical Psychology and Psychotherapy
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 192/09
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Memory
-
Kutahya Health Sciences UniversityCompletedWorking Memory | The Working Memory QuestionnaireTurkey
-
Prof. Dominique de Quervain, MDClinical Trial Unit, University Hospital Basel, SwitzerlandCompletedMemory, Short-Term | Memory, Long-TermSwitzerland
-
Memorial Sloan Kettering Cancer CenterCompletedMemory Losses | Amnesia-Memory LossUnited States
-
University of Electronic Science and Technology...CompletedOxytocin Effect on Memory Performance During Phase 1 | Oxytocin Effect on Memory Performance During Phase 2 | Oxytocin Effect on Memory Performance During Phase 3 | Oxytocin Effect on Memory Performance During Phase 4China
-
Colorado State UniversityInstitute of Cannabis ResearchCompleted
-
University Hospital, GrenobleTIMC-IMAGUnknown
-
University of Maryland, College ParkUniversity of Massachusetts, AmherstRecruiting
-
Prof. Dominique de Quervain, MDNot yet recruiting
-
University of PennsylvaniaRecruiting
-
University of BaselTerminated
Clinical Trials on Show distressing movie and tell half of the two study groups to suppress memories of the movie
-
Ya-Wei XuCompletedHeart Failure With Preserved Ejection Fraction
-
University Medical Centre LjubljanaCompletedFood AllergySlovenia
-
Merck Sharp & Dohme LLCCompleted
-
Integrative Health Technologies, Inc.UnknownHyperlipidemia | Hypercholesteremia | CholesterolUnited States
-
Memorial Sloan Kettering Cancer CenterCompleted
-
Assistance Publique - Hôpitaux de ParisCompletedPostoperative PainFrance
-
Memorial Sloan Kettering Cancer CenterNational Cancer Institute (NCI)CompletedNeuroblastomaUnited States
-
Rabin Medical CenterTel Aviv University; The Leona M. and Harry B. Helmsley Charitable TrustRecruiting