Acquisition and Retention of Motor Memories in Adults and Typically Developing Children (MOTORMEMO)

Acquisition and Retention of Motor Memories in Adults and Typically Developing Children. IRM f Study

Our motor skills require motor memories without which our behavior is only reflexes and stereotypies. The way which these memories form in the human brain constitute therefore a major challenge for neuroscience research. Some a lot of evidence suggests that any new motor skills is acquired in the cerebellum and then persisted in the cortex. This vision seems however caricature, the formation of memories motor probably requiring complex remodeling of cortico-cerebellar networks. The MotorMemo project aspires to better understand this remodeling, by testing more specifically the hypothesis of cerebellar weakening and strengthening cortical as a substrate for the formation of motor memories. A longitudinal study using a sensorimotor adaptation protocol, fMRI as well as a developmental perspective is proposed to verify this hypothesis.

Study Overview

• Status: Unknown
• Conditions: Memory
• Intervention / Treatment: Other: Functionel MRI

Detailed Description

A fundamental human faculty is that of adapting our motor behavior to changing environmental conditions. This faculty is comparable to an apprenticeship adaptive during which the individual updates, on a trial and error basis, the correspondence between sensory inputs and the resulting motor commands. Once updated, these correspondences or internal models allow the individual to produce a behavior precise and reproducible motor. The issue of model acquisition and retention internal movement is therefore central to our understanding of motor control. Relatedly, this question constitutes a gateway to a more comprehensive understanding of the mechanisms of learning and procedural memory.

The MotorMemo project therefore aims to study the formation of internal models of movement in the human brain, with the particularity of being interested in the correlates cerebral processes of acquiring and retaining an internal model of visuomotor transformation in healthy children (8-12 years) and adults.

• Study Type: Interventional
• Enrollment (Anticipated): 60
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Grenoble, France, 38043
    • Recruiting
    • CHU Grenoble-Alpes
    • Contact: Fabien cignetti; Email: fabien.cignetti@univ-grenoble-alpes.fr
    • Principal Investigator: Aurélien COURVOISIER

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 8 years to 40 years (Child, Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• right-handed
• affiliated to a social security scheme
• who gave their consent to participate in the study

Exclusion Criteria:

• Contraindication to MRI
• visual impairment;

• suffering from one of the following pathologies:

  • dysphasia,
  • ADHD,
  • dyspraxia,
  • dyslexia,
  • dysorthography,
  • dyscalculia;
  • history of epilepsy
• subject in period of exclusion from another study,
• subject under administrative or judicial supervision
• pregnant or breastfeeding women
• Persons referred to in articles l1121-8

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Adults; The subject will be subjected to 2 functional MRI sessions spaced 3 days apart Each session will be composed of the same MRI sequences without injection, namely an anatomical exploration sequence followed by sequences of functional exploration of rest and activation (while the subject performs the task motor). The resting functional exploration sequences will frame (1 before, 1 after) the functional activation sequence.	Other: Functionel MRI; During the activation fMRI sequences, the subject will perform target pointing tasks, that is to say that he will have to reach, by controlling a cursor using a non-magnetic joystick, targets projected onto a display screen. In each of the pointing tasks he will have to reach the target as quickly and as precisely as possible, and stay in the center of it for a long time times reached.
Experimental: Children; The subject will be subjected to 2 functional MRI sessions spaced 3 days apart Each session will be composed of the same MRI sequences without injection, namely an anatomical exploration sequence followed by sequences of functional exploration of rest and activation (while the subject performs the task motor). The resting functional exploration sequences will frame (1 before, 1 after) the functional activation sequence.	Other: Functionel MRI; During the activation fMRI sequences, the subject will perform target pointing tasks, that is to say that he will have to reach, by controlling a cursor using a non-magnetic joystick, targets projected onto a display screen. In each of the pointing tasks he will have to reach the target as quickly and as precisely as possible, and stay in the center of it for a long time times reached.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Evaluate, in adults and children, whether the acquisition and retention of a new internal movement pattern are linked to the activation of a large cortico-cerebellar network ladder.	Change in cerebellar activation and cortical induced by the visuomotor adaptation task compared to a task motor control not requiring adaptation	3 days

Collaborators and Investigators

• Sponsor: University Hospital, Grenoble
• Collaborators: TIMC-IMAG

Study record dates

Study Major Dates

• Study Start (Actual): October 20, 2020
• Primary Completion (Anticipated): October 1, 2022
• Study Completion (Anticipated): November 1, 2022

Study Registration Dates

• First Submitted: October 16, 2020
• First Submitted That Met QC Criteria: October 16, 2020
• First Posted (Actual): October 22, 2020

Study Record Updates

• Last Update Posted (Actual): November 17, 2020
• Last Update Submitted That Met QC Criteria: November 16, 2020
• Last Verified: November 1, 2020

More Information

Terms related to this study

• Other Study ID Numbers: 38RC20.005

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No